Search Results - "Radda, George"

Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression by Ericksen, Russell E., Lim, Siew Lan, McDonnell, Eoin, Shuen, Wai Ho, Vadiveloo, Maya, White, Phillip J., Ding, Zhaobing, Kwok, Royston, Lee, Philip, Radda, George K., Toh, Han Chong, Hirschey, Matthew D., Han, Weiping

“…Tumors display profound changes in cellular metabolism, yet how these changes aid the development and growth of tumors is not fully understood. Here we use a…”
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In Vivo hyperpolarized carbon‐13 magnetic resonance spectroscopy reveals increased pyruvate carboxylase flux in an insulin‐resistant mouse model by Lee, Philip, Leong, Waifook, Tan, Trish, Lim, Miangkee, Han, Weiping, Radda, George K.

“…The pathogenesis of type 2 diabetes is characterized by impaired insulin action and increased hepatic glucose production (HGP). Despite the importance of…”
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FoxO1 negatively regulates leptin-induced POMC transcription through its direct interaction with STAT3 by Ma, Wei, Fuentes, Gloria, Shi, Xiaohe, Verma, Chandra, Radda, George K, Han, Weiping

“…FoxO1, which is up-regulated during early stages of diet-induced leptin resistance, directly interacts with STAT3 and prevents STAT3 from binding to…”
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In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance by Schroeder, Marie A, Cochlin, Lowri E, Heather, Lisa C, Clarke, Kieran, Radda, George K, Tyler, Damian J

“…The advent of hyperpolarized ¹³C magnetic resonance (MR) has provided new potential for the real-time visualization of in vivo metabolic processes. The aim of…”
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Seipin differentially regulates lipogenesis and adipogenesis through a conserved core sequence and an evolutionarily acquired C-terminus by Yang, Wulin, Thein, Shermaine, Guo, Xiangxiang, Xu, Feng, Venkatesh, Byrappa, Sugii, Shigeki, Radda, George K, Han, Weiping

“…Homozygous mutations in BSCL2 (Berardinelli-Seip congenital lipodystrophy)/seipin cause CGL2 (congenital generalized lipodystrophy type 2). Recent data suggest…”
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Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma by Woo, Chern Chiuh, Chen, Way Cherng, Teo, Xing Qi, Radda, George K, Lee, Philip Teck Hock

“…Serine-glycine biosynthetic pathway diverts the glycolytic intermediate 3-phosphoglycerate to synthesize serine and glycine, of which the latter was found to…”
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Regulation of adipogenesis by cytoskeleton remodelling is facilitated by acetyltransferase MEC-17-dependent acetylation of α-tubulin by Yang, Wulin, Guo, Xiangxiang, Thein, Shermaine, Xu, Feng, Sugii, Shigeki, Baas, Peter W, Radda, George K, Han, Weiping

“…Cytoskeleton remodelling is a prerequisite step for the morphological transition from preadipocytes to mature adipocytes. Although microtubules play a pivotal…”
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Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice by Gustavsson, Natalia, Lao, Ye, Maximov, Anton, Chuang, Jen-Chieh, Kostromina, Elena, Repa, Joyce J, Li, Cai, Radda, George K, Südhof, Thomas C, Han, Weiping

“…Vertebrates express at least 15 different synaptotagmins with the same domain structure but diverse localizations and tissue distributions. Synaptotagmin-1,-2,…”
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Reduced body weight and increased energy expenditure in transgenic mice over-expressing soluble leptin receptor by Lou, Phing-How, Yang, Guoqing, Huang, Lu, Cui, Yunxia, Pourbahrami, Tiffany, Radda, George K, Li, Cai, Han, Weiping

“…Soluble leptin receptor (OBRe), one of several leptin receptor isoforms, is the only bona fide leptin binding protein in plasma. Our earlier studies…”
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Suppression of adipogenesis by pathogenic seipin mutant is associated with inflammatory response by Qiu, Wenjie, Wee, Kenneth, Takeda, Kosuke, Lim, Xuemei, Sugii, Shigeki, Radda, George K, Han, Weiping

“…While pathogenic mutations in BSCL2/Seipin cause congenital generalized lipodystrophy, the underlying mechanism is largely unknown. In this study, we…”
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Role of Pyruvate Dehydrogenase Inhibition in the Development of Hypertrophy in the Hyperthyroid Rat Heart: A Combined Magnetic Resonance Imaging and Hyperpolarized Magnetic Resonance Spectroscopy Study by ATHERTON, Helen J, DODD, Michael S, HEATHER, Lisa C, SCHROEDER, Marie A, GRIFFIN, Julian L, RADDA, George K, CLARKE, Kieran, TYLER, Damian J

“…Hyperthyroidism increases heart rate, contractility, cardiac output, and metabolic rate. It is also accompanied by alterations in the regulation of cardiac…”
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Molecular imaging perspectives by Cassidy, Paul J, Radda, George K

“…Molecular imaging is an emerging technology at the life science/physical science interface which is set to revolutionize our understanding and treatment of…”
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A new hyperpolarized 13C ketone body probe reveals an increase in acetoacetate utilization in the diabetic rat heart by Abdurrachim, Desiree, Woo, Chern Chiuh, Teo, Xing Qi, Chan, Wei Xin, Radda, George K., Lee, Philip Teck Hock

“…Emerging studies have recently shown the potential importance of ketone bodies in cardio-metabolic health. However, techniques to determine myocardial ketone…”
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FoxO1 Inhibits Leptin Regulation of Pro-opiomelanocortin Promoter Activity by Blocking STAT3 Interaction with Specificity Protein 1 by Yang, Guoqing, Lim, Chun-Yan, Li, Chao, Xiao, Xiaoqiu, Radda, George K., Li, Cai, Cao, Xinmin, Han, Weiping

“…Leptin controls food intake and energy expenditure by regulating hypothalamic neuron activities. Leptin exerts its actions through complex signaling pathways…”
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Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy by Dodd, Michael S, Atherton, Helen J, Carr, Carolyn A, Stuckey, Daniel J, West, James A, Griffin, Julian L, Radda, George K, Clarke, Kieran, Heather, Lisa C, Tyler, Damian J

“…Myocardial infarction (MI) is one of the leading causes of heart failure. An increasing body of evidence links alterations in cardiac metabolism and…”
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Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+-induced glucagon exocytosis in pancreas by Gustavsson, Natalia, Wei, Shun‐Hui, Hoang, Dong Nhut, Lao, Ye, Zhang, Quan, Radda, George K., Rorsman, Patrik, Südhof, Thomas C., Han, Weiping

“…Hormones such as glucagon are secreted by Ca 2+ -induced exocytosis of large dense-core vesicles, but the mechanisms involved have only been partially…”
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Robust hyperpolarized (13)C metabolic imaging with selective non-excitation of pyruvate (SNEP) by Chen, Way Cherng, Teo, Xing Qi, Lee, Man Ying, Radda, George K, Lee, Philip

“…In vivo metabolic imaging using hyperpolarized [1-(13)C]pyruvate provides localized biochemical information and is particularly useful in detecting early…”
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Increased lipolysis and energy expenditure in a mouse model with severely impaired glucagon secretion by Lou, Phing-How, Gustavsson, Natalia, Wang, Yue, Radda, George K, Han, Weiping

“…Secretion of insulin and glucagon is triggered by elevated intracellular calcium levels. Although the precise mechanism by which the calcium signal is coupled…”
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Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes by SCHEUERMANN-FREESTONE, Michaela, MADSEN, Per L, MANNERS, David, BLAMIRE, Andrew M, BUCKINGHAM, Robin E, STYLES, Peter, RADDA, George K, NEUBAUER, Stefan, CLARKE, Kieran

“…It is well known that patients with type 2 diabetes have increased risk of cardiovascular disease, but it is not known whether they have underlying…”
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Uncoupling proteins in human heart by Murray, Andrew J, Anderson, Russell E, Watson, Gillian C, Radda, George K, Clarke, Kieran

“…Abnormal energetic activity in heart failure correlates inversely with plasma free-fatty-acid concentrations. However, the link between energetic and metabolic…”
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