Search Results - "Radcliff, Abigail B."

The adult oligodendrocyte can participate in remyelination by Duncan, Ian D., Radcliff, Abigail B., Heidari, Moones, Kidd, Grahame, August, Benjamin K., Wierenga, Lauren A.

“…Endogenous remyelination of the CNS can be robust and restore function, yet in multiple sclerosis it becomes less complete with time. Promoting remyelination…”
Get full text

Gestational intermittent hypoxia increases FosB‐immunoreactive perikaryas in the paraventricular nucleus of the hypothalamus of adult male (but not female) rats by Ambrozio‐Marques, Danuzia, Gagnon, Marianne, Radcliff, Abigail B., Meza, Armand L., Baker, Tracy L., Watters, Jyoti J., Kinkead, Richard

“…Sleep‐disordered breathing is a respiratory disorder commonly experienced by pregnant women. The recurrent hypoxaemic events associated with sleep‐disordered…”
Get full text

A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring by Vanderplow, Amanda M, Kermath, Bailey A, Bernhardt, Cassandra R, Gums, Kimberly T, Seablom, Erin N, Radcliff, Abigail B, Ewald, Andrea C, Jones, Mathew V, Baker, Tracy L, Watters, Jyoti J, Cahill, Michael E

“…Mounting epidemiologic and scientific evidence indicates that many psychiatric disorders originate from a complex interplay between genetics and early life…”
Get full text

Sex- and Region-Specific Differences in the Transcriptomes of Rat Microglia from the Brainstem and Cervical Spinal Cord by Ewald, Andrea C, Kiernan, Elizabeth A, Roopra, Avtar S, Radcliff, Abigail B, Timko, Rebecca R, Baker, Tracy L, Watters, Jyoti J

“…The neural control system underlying breathing is sexually dimorphic with males being more vulnerable to dysfunction. Microglia also display sex differences,…”
Get full text

Feline irradiated diet-induced demyelination; a model of the neuropathology of sub-acute combined degeneration? by Radcliff, Abigail B, Heidari, Moones, Field, Aaron S, Duncan, Ian D

“…Irradiation of food at 50-55 kGy results in a profound, chronic demyelinating-remyelinating disease of the entire central nervous system (CNS) in cats, named…”
Get full text

Gestational Intermittent Hypoxia Enhances Mammary Stem Cells and Alters Tumor Phenotype in Adult Female Offspring by Joshi, Jaitri, Xiong, Yue, Kuhn, Molly, Radcliff, Abigail B, Baker, Tracy L, Watters, Jyoti J, Arendt, Lisa M

“…An adverse perinatal environment can increase long-term cancer risk, although the precise nature of associated perinatal triggers remain unknown. Sleep apnea…”
Get full text

Modeling the natural history of Pelizaeus–Merzbacher disease by Mayer, Joshua A, Griffiths, Ian R, Goldman, James E, Smith, Chelsey M, Cooksey, Elizabeth, Radcliff, Abigail B, Duncan, Ian D

“…Abstract Major gaps in our understanding of the leukodystrophies result from their rarity and the lack of tissue for the interdisciplinary studies required to…”
Get full text

Congenic Strains Confirm the Pleiotropic Effect of Chromosome 4 QTL on Mouse Femoral Geometry and Biomechanical Performance by Kristianto, Jasmin, Litscher, Suzanne J, Johnson, Michael G, Patel, Forum, Patel, Mital, Fisher, Jacqueline, Zastrow, Ryley K, Radcliff, Abigail B, Blank, Robert D

“…A pleiotropic quantitative trait locus (QTL) for bone geometry and mechanical performance in mice was mapped to distal chromosome 4 via an intercross of…”
Get full text

Inherited and acquired disorders of myelin: The underlying myelin pathology by Duncan, Ian D., Radcliff, Abigail B.

“…Remyelination is a major therapeutic goal in human myelin disorders, serving to restore function to demyelinated axons and providing neuroprotection. The…”
Get full text

Evoked potentials as a biomarker of remyelination by Heidari, Moones, Radcliff, Abigail B., McLellan, Gillian J., Ver Hoeve, James N., Chan, Kore, Kiland, Julie A., Keuler, Nicholas S., August, Benjamin K., Sebo, Dylan, Field, Aaron S., Duncan, Ian D.

“…Multiple sclerosis (MS) is a common cause of neurologic disease in young adults that is primarily treated with disease-modifying therapies which target the…”
Get full text

Spontaneous recombinase activity of Cre–ERT2 in vivo by Kristianto, Jasmin, Johnson, Michael G., Zastrow, Ryley K., Radcliff, Abigail B., Blank, Robert D.

“…Inducible Cre–ERT recombinase technology is widely used for gene targeting studies. The second generation of inducible Cre–ERT recombinase, hemizygous…”
Get full text

A mutation in the Tubb4a gene leads to microtubule accumulation with hypomyelination and demyelination by Duncan, Ian D., Bugiani, Marianna, Radcliff, Abigail B., Moran, John J., Lopez‐Anido, Camila, Duong, Phu, August, Benjamin K., Wolf, Nicole I., van der Knaap, Marjo S., Svaren, John

“…Objective Our goal was to define the genetic cause of the profound hypomyelination in the taiep rat model and determine its relevance to human white matter…”
Get full text

Butyrate supplementation rescues sex‐specific deficits in respiratory plasticity and mean arterial pressure in adult offspring exposed to gestational intermittent hypoxia by Mickelson, Carly R., Kobitter, Emma P., Meza, Armand L., Song, Ruolin, Mishra, Jay S., McCann, Erin C., Radcliff, Abigail B., Hill, Kelsea K., Kumar, Sathish, Watters, Jyoti J., Baker, Tracy L.

“…Sleep disordered breathing (SDB) in pregnancy is increasing in parallel with the obesity epidemic, and is linked to adverse perinatal outcomes in the…”
Get full text

Pharmacologic Microglial Depletion Disrupts Breathing and Body Temperature Regulation During Torpor in 13‐lined Ground Squirrels by Sprenger, Ryan J., Radcliff, Abigail B., Meza, Armand L., Mickelson, Carly R., Watters, Abby, Romero, Phinea Z., Milsom, William, Carey, Hannah V., Watters, Jyoti J., Baker, Tracy L.

“…Mammalian hibernation initiates dramatic changes in physiology that include large reductions in ventilation (V̇E), heart rate, oxygen consumption rate (V̇o2),…”
Get full text

Myelin and oligodendrocyte development in the canine spinal cord by Mayer, Joshua A., Figari, Carlos, Radcliff, Abigail B., Mckee, Camille, Duncan, Ian D.

“…ABSTRACT We studied the developmental pattern of oligodendrocyte differentiation and myelin formation in the fetal canine spinal cord from E40 to P0. The…”
Get full text

Modeling the Chronic Loss of Optic Nerve Axons and the Effects on the Retinal Nerve Fiber Layer Structure in Primary Disorder of Myelin by Teixeira, Leandro B C, Hoeve, James N Ver, Mayer, Joshua A, Dubielzig, Richard R, Smith, Chelsey M, Radcliff, Abigail B, Duncan, Ian D

“…We determined whether the chronic lack of optic nerve myelination and subsequent axon loss is associated with optical coherence tomography (OCT) changes in the…”
Get full text

Spontaneous optic nerve compression in the osteopetrotic (op/op) mouse: a novel model of myelination failure by Kondo, Yoichi, Ramaker, Jenna M, Radcliff, Abigail B, Baldassari, Simona, Mayer, Joshua A, Ver Hoeve, James N, Zhang, Chuan-Li, Chiu, Shing-Yan, Colello, Raymond J, Duncan, Ian D

“…We report a focal disturbance in myelination of the optic nerve in the osteopetrotic (op/op) mouse, which results from a spontaneous compression of the nerve…”
Get full text

Inhibition of Spinal Inflammation Restores Compensatory Plasticity Induced by Recurrent Reductions in Respiratory Neural Activity in Offspring Exposed to Gestational Intermittent Hypoxia by Mickelson, Carly R., Gumnit, Maia G., Meza, Armand L., Radcliff, Abigail B., Watters, Jyoti J., Baker, Tracy L.

“…Abstract only Sleep disordered breathing (SDB) during pregnancy is increasing in parallel with the obesity epidemic, yet the long‐term effects on the adult…”
Get full text

Congenic Strains Confirm the Pleiotropic Effect of Chromosome 4 QTL on Mouse Femoral Geometry and Biomechanical Performance: e0148571 by Kristianto, Jasmin, Litscher, Suzanne J, Johnson, Michael G, Patel, um, Patel, Mital, Fisher, Jacqueline, Zastrow, Ryley K, Radcliff, Abigail B, Blank, Robert D

“…A pleiotropic quantitative trait locus (QTL) for bone geometry and mechanical performance in mice was mapped to distal chromosome 4 via an intercross of…”
Get full text