Search Results - "Racz, William J."

Mechanisms of amiodarone and desethylamiodarone cytotoxicity in nontransformed human peripheral lung epithelial cells by Mulder, Jeanne E, Brien, James F, Racz, William J, Takahashi, Takashi, Massey, Thomas E

“…Amiodarone (AM) is a potent antidysrhythmic agent that can cause potentially life-threatening pulmonary fibrosis, and N-desethylamiodarone (DEA), an AM…”
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The role of mitochondrial injury in bromobenzene and furosemide induced hepatotoxicity by Wong, Simon G.W, Card, Jeffrey W, Racz, William J

“…Bromobenzene (BB) and furosemide (FS) are two hepatotoxicants whose bioactivation to reactive intermediates is crucial to the development of liver injury…”
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Mitochondrial dysfunction is an early manifestation of 1,1-dichloroethylene-induced hepatotoxicity in mice by Martin, Erik J, Racz, William J, Forkert, Poh-Gek

“…Hepatotoxicity induced by 1,1-dichloroethylene (DCE) is mediated by cytochrome P450-dependent metabolism to reactive intermediates, including the epoxide. We…”
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Direct mitochondrial dysfunction precedes reactive oxygen species production in amiodarone-induced toxicity in human peripheral lung epithelial HPL1A cells by Nicolescu, Adrian C., Ji, Yanbin, Comeau, Jeannette L., Hill, Bruce C., Takahashi, Takashi, Brien, James F., Racz, William J., Massey, Thomas E.

“…Amiodarone (AM), a drug used in the treatment of cardiac dysrrhythmias, can produce severe pulmonary adverse effects, including fibrosis. Although the…”
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Differential Effects of Pirfenidone on Acute Pulmonary Injury and Ensuing Fibrosis in the Hamster Model of Amiodarone-Induced Pulmonary Toxicity by Card, Jeffrey W., Racz, William J., Brien, James F., Margolin, Solomon B., Massey, Thomas E.

“…Pulmonary toxicity, including fibrosis, is a serious adverse effect associated with the antidysrhythmic drug amiodarone (AM). We tested the potential…”
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Aryl radical involvement in amiodarone-induced pulmonary toxicity: Investigation of protection by spin-trapping nitrones by Nicolescu, Adrian C., Comeau, Jeannette L., Hill, Bruce C., Bedard, Leanne L., Takahashi, Takashi, Brien, James F., Racz, William J., Massey, Thomas E.

“…Amiodarone (AM), an antidysrrhythmic drug, can produce serious adverse effects, including potentially fatal AM-induced pulmonary toxicity (AIPT). AM-induced…”
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Intracellular calcium disruption as a secondary event in acetaminophen-induced hepatotoxicity by Grewal, K K, Racz, W J

“…To examine a role for disturbances in intracellular calcium homeostasis in acetaminophen-induced hepatotoxicity, freshly isolated mouse hepatocytes were…”
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Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicity by DONNELLY, P. J, WALKER, R. M, RACZ, W. J

“…Morphological changes in mitochondria are observed early in the course of acetaminophen (AA)-induced hepatotoxicity, and mitochondrial dysfunction has been…”
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On-line sources of toxicological information in Canada by Racz, William J, Ecobichon, Donald J, Baril, Marc

“…This paper will provide an overview of the on-line resources available in toxicology in Canada. It will describe a brief history of The Society of Toxicology…”
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Amiodarone-induced disruption of hamster lung and liver mitochondrial function: lack of association with thiobarbituric acid-reactive substance production by Card, Jeffrey W, Lalonde, Brendon R, Rafeiro, Elizabeth, Tam, Andrew S, Racz, William J, Brien, James F, Bray, Tammy M, Massey, Thomas E

“…Amiodarone (AM) is an efficacious antidysrhythmic agent that is limited clinically by numerous adverse effects. Of greatest concern is AM-induced pulmonary…”
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Acetaminophen toxicity in fed and fasted mice by Walker, R M, Massey, T E, McElligott, T F, Racz, W J

“…Acetaminophen (750 mg/kg) toxicity and its modification by N-acetylcysteine (NAC, 1200 mg/kg) have been compared in fed and fasted mice. There was no…”
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Effects of N-acetylcysteine and dithiothreitol on glutathione and protein thiol replenishment during acetaminophen-induced toxicity in isolated mouse hepatocytes by Rafeiro, E, Barr, S G, Harrison, J J, Racz, W J

“…Isolated mouse hepatocytes were incubated with 1.0 mM acetaminophen (AA) for 1.5 h to initiate glutathione (GSH) and protein thiol (PSH) depletion and cell…”
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Effects of N-acetylcysteine on metabolism, covalent binding, and toxicity of acetaminophen in isolated mouse hepatocytes by Massey, T E, Racz, W J

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Metal ion-biomolecule interactions. Synthesis, spectroscopic, and magnetic resonance investigations of methylmercury(II) complexes of the nucleosides guanosine and inosine by Buncel, Erwin, Norris, Albert R, Racz, William J, Taylor, Spencer E

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On-line sources of toxicological information in Canada: Digital Information and Tools, Part III - Global Web Resources by RACZ, William J, ECOBICHON, Donald J, BARIL, Marc

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Acetaminophen-induced hypothermia in mice: evidence for a central action of the parent compound by Massey, T E, Walker, R M, McElligott, T F, Racz, W J

“…Pretreatment of mice with phenobarbital, an inducer of oxidative drug metabolism, had no effect on the early hypothermic effect of a toxic dose of…”
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Perspectives on the central nervous system toxicity of methylmercury by Racz, W J, Vandewater, L J

“…Methylmercury is a widespread and highly toxic environmental pollutant. The source of the substance in the environment is industrial and agricultural use…”
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Attenuation of amiodarone-induced pulmonary fibrosis by vitamin E is associated with suppression of transforming growth factor-beta1 gene expression but not prevention of mitochondrial dysfunction by Card, Jeffrey W, Racz, William J, Brien, James F, Massey, Thomas E

“…Amiodarone (AM) is an efficacious antidysrhythmic agent that can cause numerous adverse effects, including potentially life-threatening pulmonary fibrosis. The…”
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Methylmercury distribution, metabolism, and neurotoxicity in the mouse brain by Vandewater, L J, Racz, W J, Norris, A R, Buncel, E

“…Methylmercury distribution, biotransformation, and neurotoxicity in the brain of male Swiss albino mice were investigated. Mice were orally dosed with [203…”
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Effects of porphyrin-inducing drugs on ferrochelatase activity in isolated mouse hepatocytes by Cole, S P, Massey, T E, Marks, G S, Racz, W J

“…The effects of several concentrations of griseofulvin and 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine (DDC) on ferrochelatase activity in…”
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