Search Results - "Racz, W J"

Disruption of mitochondrial function and cellular ATP levels by amiodarone and N-desethylamiodarone in initiation of amiodarone-induced pulmonary cytotoxicity by Bolt, M W, Card, J W, Racz, W J, Brien, J F, Massey, T E

“…Amiodarone (AM), a potent antidysrhythmic agent, can cause potentially life-threatening pulmonary fibrosis. In the present investigation of mechanisms of…”
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Effects of vitamin E on cytotoxicity of amiodarone and N-desethylamiodarone in isolated hamster lung cells by Bolt, M.W, Racz, W.J, Brien, J.F, Massey, T.E

“…Amiodarone (AM) is a potent and efficacious antidysrhythmic agent that can cause potentially life-threatening pulmonary fibrosis. Vitamin E has been…”
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Inhibition of mitochondrial respiration in vivo is an early event in acetaminophen-induced hepatotoxicity by DONNELLY, P. J, WALKER, R. M, RACZ, W. J

“…Morphological changes in mitochondria are observed early in the course of acetaminophen (AA)-induced hepatotoxicity, and mitochondrial dysfunction has been…”
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Effects of N-acetylcysteine on acetaminophen covalent binding and hepatic necrosis in mice by Corcoran, G B, Racz, W J, Smith, C V, Mitchell, J R

“…Experiments were designed to test whether the protective effect of N-acetylcysteine against acetaminophen hepatotoxicity precedes arylation of tissue or…”
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Effects of dietary vitamin E supplementation on pulmonary morphology and collagen deposition in amiodarone- and vehicle-treated hamsters by Card, Jeffrey W., Leeder, Randall G., Racz, William J., Brien, James F., Bray, Tammy M., Massey, Thomas E.

“…Amiodarone (AM) is a potent antidysrhythmic agent that is limited in clinical use by its adverse effects, including potentially life-threatening AM-induced…”
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The effects of methylmercury on endogenous dopamine efflux from mouse striatal slices by Kalisch, Bettina E., Racz, William J.

“…The present study investigated the effects of in vitro methylmercury (MeHg) exposure on endogenous dopamine (DA) efflux from mouse striatal slices. MeHg…”
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Amiodarone-induced disruption of hamster lung and liver mitochondrial function: lack of association with thiobarbituric acid-reactive substance production by Card, Jeffrey W, Lalonde, Brendon R, Rafeiro, Elizabeth, Tam, Andrew S, Racz, William J, Brien, James F, Bray, Tammy M, Massey, Thomas E

“…Amiodarone (AM) is an efficacious antidysrhythmic agent that is limited clinically by numerous adverse effects. Of greatest concern is AM-induced pulmonary…”
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On-line sources of toxicological information in Canada by Racz, William J, Ecobichon, Donald J, Baril, Marc

“…This paper will provide an overview of the on-line resources available in toxicology in Canada. It will describe a brief history of The Society of Toxicology…”
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Differential susceptibilities of isolated hamster lung cell types to amiodarone toxicity by Bolt, M W, Racz, W J, Brien, J F, Bray, T M, Massey, T E

“…Treatment of cardiac dysrhythmias with the iodinated benzofuran derivative amiodarone (AM) is limited by pulmonary toxicity. The susceptibilities of different…”
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Intracellular calcium disruption as a secondary event in acetaminophen-induced hepatotoxicity by Grewal, K K, Racz, W J

“…To examine a role for disturbances in intracellular calcium homeostasis in acetaminophen-induced hepatotoxicity, freshly isolated mouse hepatocytes were…”
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Effects of an environmental anti-androgen on erectile function in an animal penile erection model by Brien, S E, Heaton, J P, Racz, W J, Adams, M A

“…Erectile function is testosterone dependent. For example, interference with either the levels or receptor binding of this steroid hormone may induce erectile…”
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Alternative methods of selecting rat hepatocellular nodules resistant to 2-acetylaminofluorene by Semple-Roberts, E, Hayes, M A, Armstrong, D, Becker, R A, Racz, W J, Farber, E

“…Dietary 2-acetylaminofluorene (2-AAF) coupled with a stimulus for cell proliferation such as a 2/3 partial hepatectomy (PH) or a necrotizing dose of carbon…”
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Effects of N-acetylcysteine on the disposition and metabolism of acetaminophen in mice by Corcoran, G B, Todd, E L, Racz, W J, Hughes, H, Smith, C V, Mitchell, J R

“…N-acetylcysteine is the drug of choice for the treatment of acetaminophen poisoning, yet the mechanism of protection in vivo is unknown. Prevention of liver…”
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Differential Effects of Pirfenidone on Acute Pulmonary Injury and Ensuing Fibrosis in the Hamster Model of Amiodarone-Induced Pulmonary Toxicity by Card, Jeffrey W., Racz, William J., Brien, James F., Margolin, Solomon B., Massey, Thomas E.

“…Pulmonary toxicity, including fibrosis, is a serious adverse effect associated with the antidysrhythmic drug amiodarone (AM). We tested the potential…”
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Effects of methylmercury on the spontaneous and potassium-evoked release of endogenous amino acids from mouse cerebellar slices by Reynolds, J N, Racz, W J

“…The effects of methylmercury on the spontaneous and potassium-evoked release of endogenous amino acids from mouse cerebellar slices have been examined…”
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Scanning electron microscopic examination of acetaminophen-induced hepatotoxicity and congestion in mice by Walker, RM, Racz, WJ, McElligott, TF

“…Acetaminophen-induced hepatotoxicity and associated hepatic congestion were investigated by scanning and correlative transmission electron microscopy…”
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Metabolic activation of 1,1-dichloroethylene by mouse lung and liver microsomes by Forkert, P G, Hofley, M, Racz, W J

“…1,1-Dichloroethylene (1,1-DCE) causes lung and liver necrosis in mice. Covalent binding of [14C]1,1-DCE to isolated lung and liver microsomes from CD-1 mice…”
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Effects of mercury compounds on the spontaneous and potassium-evoked release of [3H]dopamine from mouse striatal slices by McKay, S J, Reynolds, J N, Racz, W J

“…The effects of mercury compounds on the spontaneous and potassium-evoked release of [3H]dopamine from mouse striatal slices have been examined. All mercury…”
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The role of mitochondrial injury in bromobenzene and furosemide induced hepatotoxicity by Wong, Simon G.W, Card, Jeffrey W, Racz, William J

“…Bromobenzene (BB) and furosemide (FS) are two hepatotoxicants whose bioactivation to reactive intermediates is crucial to the development of liver injury…”
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Effects of administration of metabolic inducers and inhibitors on pulmonary toxicity and covalent binding by 1,1-dichloroethylene in CD-1 mice by Forkert, P G, Stringer, V, Racz, W J

“…The administration of 1,1-dichloroethylene (1,1-DCE, 125 mg/kg ip) to CD-1 mice caused bronchiolar necrosis, which was accompanied by substantial covalent…”
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