Search Results - "Racine, Jeremy J."

Editorial: Genetic basis of tolerance induction defects underlying the development of autoimmune pathologies by Racine, Jeremy J, Morel, Laurence, Chen, Yi-Guang, Serreze, David V

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HLA-B39:06 Efficiently Mediates Type 1 Diabetes in a Mouse Model Incorporating Reduced Thymic Insulin Expression by Schloss, Jennifer, Ali, Riyasat, Racine, Jeremy J, Chapman, Harold D, Serreze, David V, DiLorenzo, Teresa P

“…Type 1 diabetes (T1D) is characterized by T cell-mediated destruction of the insulin-producing β cells of the pancreatic islets. Among the loci associated with…”
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Improved Murine MHC-Deficient HLA Transgenic NOD Mouse Models for Type 1 Diabetes Therapy Development by Racine, Jeremy J, Stewart, Isabel, Ratiu, Jeremy, Christianson, Greg, Lowell, Emily, Helm, Kelsay, Allocco, Jennifer, Maser, Richard S, Chen, Yi-Guang, Lutz, Cathleen M, Roopenian, Derry, Schloss, Jennifer, DiLorenzo, Teresa P, Serreze, David V

“…Improved mouse models for type 1 diabetes (T1D) therapy development are needed. T1D susceptibility is restored to normally resistant NOD.β2m mice…”
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Nfkbid Overexpression in Nonobese Diabetic Mice Elicits Complete Type 1 Diabetes Resistance in Part Associated with Enhanced Thymic Deletion of Pathogenic CD8 T Cells and Increased Numbers and Activity of Regulatory T Cells by Dwyer, Jennifer R, Racine, Jeremy J, Chapman, Harold D, Quinlan, Anna, Presa, Maximiliano, Stafford, Grace A, Schmitz, Ingo, Serreze, David V

“…Type 1 diabetes (T1D) in both humans and NOD mice is caused by T cell-mediated autoimmune destruction of pancreatic β cells. Increased frequency or activity of…”
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Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti-PD-1 Immune Checkpoint Inhibitor Cancer Therapy by Racine, Jeremy J, Bachman, John F, Zhang, Ji-Gang, Misherghi, Adel, Khadour, Raheem, Kaisar, Sana, Bedard, Olivia, Jenkins, Catherine, Abbott, Annie, Forte, Elvira, Rainer, Peter, Rosenthal, Nadia, Sattler, Susanne, Serreze, David V

“…Myocarditis has emerged as an immune-related adverse event of immune checkpoint inhibitor (ICI) cancer therapy associated with significant mortality. To ensure…”
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HLA-DQ8 Supports Development of Insulitis Mediated by Insulin-Reactive Human TCR-Transgenic T Cells in Nonobese Diabetic Mice by Racine, Jeremy J, Misherghi, Adel, Dwyer, Jennifer R, Maser, Richard, Forte, Elvira, Bedard, Olivia, Sattler, Susanne, Pugliese, Alberto, Landry, Laurie, Elso, Colleen, Nakayama, Maki, Mannering, Stuart, Rosenthal, Nadia, Serreze, David V

“…In an effort to improve HLA-"humanized" mouse models for type 1 diabetes (T1D) therapy development, we previously generated directly in the NOD strain…”
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Transient BAFF Blockade Inhibits Type 1 Diabetes Development in Nonobese Diabetic Mice by Enriching Immunoregulatory B Lymphocytes Sensitive to Deletion by Anti-CD20 Cotherapy by Wang, Qiming, Racine, Jeremy J, Ratiu, Jeremy J, Wang, Shu, Ettinger, Rachel, Wasserfall, Clive, Atkinson, Mark A, Serreze, David V

“…In NOD mice and also likely humans, B lymphocytes play an important role as APC-expanding autoreactive T cell responses ultimately causing type 1 diabetes…”
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MHC-mismatched mixed chimerism restores peripheral tolerance of noncross-reactive autoreactive T cells in NOD mice by Zhang, Mingfeng, Racine, Jeremy J., Lin, Qing, Liu, Yuqing, Tang, Shanshan, Qin, Qi, Qi, Tong, Riggs, Arthur D., Zeng, Defu

“…Autoimmune type 1 diabetes (T1D) and other autoimmune diseases are associated with particular MHC haplotypes and expansion of autoreactive T cells. Induction…”
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MHC-mismatched mixed chimerism mediates thymic deletion of cross-reactive autoreactive T cells and prevents insulitis in nonobese diabetic mice by Racine, Jeremy J, Zhang, Mingfeng, Wang, Miao, Morales, William, Shen, Christine, Zeng, Defu

“…Type 1 diabetic NOD mice have defects in both thymic negative selection and peripheral regulation of autoreactive T cells, and induction of mixed chimerism can…”
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Interferon-γ Limits Diabetogenic CD8 + T-Cell Effector Responses in Type 1 Diabetes by Driver, John P, Racine, Jeremy J, Ye, Cheng, Lamont, Deanna J, Newby, Brittney N, Leeth, Caroline M, Chapman, Harold D, Brusko, Todd M, Chen, Yi-Guang, Mathews, Clayton E, Serreze, David V

“…Type 1 diabetes development in the NOD mouse model is widely reported to be dependent on high-level production by autoreactive CD4 and CD8 T cells of…”
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A Hypermorphic Nfkbid Allele Contributes to Impaired Thymic Deletion of Autoreactive Diabetogenic CD8 + T Cells in NOD Mice by Presa, Maximiliano, Racine, Jeremy J, Dwyer, Jennifer R, Lamont, Deanna J, Ratiu, Jeremy J, Sarsani, Vishal Kumar, Chen, Yi-Guang, Geurts, Aron, Schmitz, Ingo, Stearns, Timothy, Allocco, Jennifer, Chapman, Harold D, Serreze, David V

“…In both NOD mice and humans, the development of type 1 diabetes (T1D) is dependent in part on autoreactive CD8 T cells recognizing pancreatic β cell peptides…”
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Genetic and Small Molecule Disruption of the AID/RAD51 Axis Similarly Protects Nonobese Diabetic Mice from Type 1 Diabetes through Expansion of Regulatory B Lymphocytes by Ratiu, Jeremy J, Racine, Jeremy J, Hasham, Muneer G, Wang, Qiming, Branca, Jane A, Chapman, Harold D, Zhu, Jing, Donghia, Nina, Philip, Vivek, Schott, William H, Wasserfall, Clive, Atkinson, Mark A, Mills, Kevin D, Leeth, Caroline M, Serreze, David V

“…B lymphocytes play a key role in type 1 diabetes (T1D) development by serving as a subset of APCs preferentially supporting the expansion of autoreactive…”
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T Cells from NOD- PerIg Mice Target Both Pancreatic and Neuronal Tissue by Racine, Jeremy J, Chapman, Harold D, Doty, Rosalinda, Cairns, Brynn M, Hines, Timothy J, Tadenev, Abigail L D, Anderson, Laura C, Green, Torrian, Dyer, Meaghan E, Wotton, Janine M, Bichler, Zoë, White, Jacqueline K, Ettinger, Rachel, Burgess, Robert W, Serreze, David V

“…It has become increasingly appreciated that autoimmune responses against neuronal components play an important role in type 1 diabetes (T1D) pathogenesis. In…”
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Induction of Mixed Chimerism Depletes Pre-existing and De Novo-Developed Autoreactive B Cells in Autoimmune NOD Mice by RACINE, Jeremy J, MIAO WANG, MINGFENG ZHANG, DEFU ZENG

“…Destruction of pancreatic islet β-cells in type 1 diabetes (T1D) is mainly mediated by autoimmune T and B lymphocytes. We reported that induction of major…”
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Administration of Anti-CD20 mAb Is Highly Effective in Preventing but Ineffective in Treating Chronic Graft-Versus-Host Disease While Preserving Strong Graft-Versus-Leukemia Effects by Johnston, Heather F, Xu, Yajing, Racine, Jeremy J, Cassady, Kaniel, Ni, Xiong, Wu, Tao, Chan, Andrew, Forman, Stephen, Zeng, Defu

“…Abstract Chronic graft-versus-host disease (cGVHD) is an autoimmune-like syndrome, and donor B cells play important roles in augmenting its pathogenesis. B…”
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Antibiotic-associated Manipulation of the Gut Microbiota and Phenotypic Restoration in NOD Mice by Fahey, James R, Lyons, Bonnie L, Olekszak, Haiyan L, Mourino, Anthony J, Ratiu, Jeremy J, Racine, Jeremy J, Chapman, Harold D, Serreze, David V, Baker, Dina L, Hendrix, N Ken

“…Segmented filamentous bacterium (SFB) a gram-positive, anaerobic, and intestinal commensal organism directly influences the development of Th17 helper cells in…”
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Mixed chimerism and growth factors augment β cell regeneration and reverse late-stage type 1 diabetes by Wang, Miao, Racine, Jeremy J, Song, Xiaoping, Li, Xiaofan, Nair, Indu, Liu, Hongjun, Avakian-Mansoorian, Alina, Johnston, Heather F, Liu, Can, Shen, Christine, Atkinson, Mark, Todorov, Ivan, Kandeel, Fouad, Forman, Stephen, Wilson, Brian, Zeng, Defu

“…Type 1 diabetes (T1D) results from an autoimmune destruction of insulin-producing β cells. Currently, islet transplantation is the only curative therapy for…”
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Induction of Chimerism Permits Low-Dose Islet Grafts in the Liver or Pancreas to Reverse Refractory Autoimmune Diabetes by CHUNYAN ZHANG, MIAO WANG, DEFU ZENG, RACINE, Jeremy J, HONGJUN LIU, LIN, Chia-Lei, NAIR, Indu, LAU, Joyce, CAO, Yu-An, TODOROV, Ivan, ATKINSON, Mark

“…To test whether induction of chimerism lowers the amount of donor islets required for reversal of diabetes and renders the pancreas a suitable site for islet…”
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A hypomorphic Ephb2 gene variant contributes to autoimmune diabetes in NOD mice associated with altered Mapk3 activities in B-lymphocytes by Wang, Qiming, Chapman, Harold D, Racine, Jeremy J, Serreze, David

“…Abstract β-cell destruction in type 1 diabetes (T1D) is considered a T-cell mediated autoimmune disease, but based on studies in the NOD mouse model,…”
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Depletion of Host CCR7+ Dendritic Cells Prevented Donor T Cell Tissue Tropism in Anti-CD3–Conditioned Recipients by He, Wei, Racine, Jeremy J, Johnston, Heather F, Li, Xiaofan, Li, Nainong, Cassady, Kaniel, Liu, Can, Deng, Ruishu, Martin, Paul, Forman, Stephen, Zeng, Defu

“…Abstract We reported previously that anti-CD3 mAb treatment before hematopoietic cell transplantation (HCT) prevented graft-versus-host disease (GVHD) and…”
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