Search Results - "Racca, Joseph"

Role of nucleobase-specific interactions in the binding and bending of DNA by human male sex determination factor SRY by Racca, Joseph D., Chen, Yen-Shan, Brabender, Adam R., Battistin, Umberto, Weiss, Michael A., Georgiadis, Millie M.

“…Y-chromosome–encoded master transcription factor SRY functions in the embryogenesis of therian mammals to initiate male development. Through interactions of…”
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Tenuous Transcriptional Threshold of Human Sex Determination. I. SRY and Swyer Syndrome at the Edge of Ambiguity by Chen, Yen-Shan, Racca, Joseph D, Weiss, Michael A

“…Male sex determination in mammals is initiated by SRY, a Y-encoded transcription factor. The protein contains a high-mobility-group (HMG) box mediating…”
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Tenuous transcriptional threshold of human sex determination. II. SRY exploits water-mediated clamp at the edge of ambiguity by Racca, Joseph D, Chatterjee, Deepak, Chen, Yen-Shan, Rai, Ratan K, Yang, Yanwu, Georgiadis, Millie M, Haas, Elisha, Weiss, Michael A

“…Y-encoded transcription factor SRY initiates male differentiation in therian mammals. This factor contains a high-mobility-group (HMG) box, which mediates…”
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Human Sex Determination at the Edge of Ambiguity: INHERITED XY SEX REVERSAL DUE TO ENHANCED UBIQUITINATION AND PROTEASOMAL DEGRADATION OF A MASTER TRANSCRIPTION FACTOR by Racca, Joseph D, Chen, Yen-Shan, Yang, Yanwu, Phillips, Nelson B, Weiss, Michael A

“…A general problem is posed by analysis of transcriptional thresholds governing cell fate decisions in metazoan development. A model is provided by testis…”
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Inherited human sex reversal due to impaired nucleocytoplasmic trafficking of SRY defines a male transcriptional threshold by Chen, Yen-Shan, Racca, Joseph D, Phillips, Nelson B, Weiss, Michael A

“…Human testis determination is initiated by SRY (sex determining region on Y chromosome). Mutations in SRY cause gonadal dysgenesis with female somatic…”
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Structure-function relationships in human testis-determining factor SRY: an aromatic buttress underlies the specific DNA-bending surface of a high mobility group (HMG) box by Racca, Joseph D, Chen, Yen-Shan, Maloy, James D, Wickramasinghe, Nalinda, Phillips, Nelson B, Weiss, Michael A

“…Human testis determination is initiated by SRY, a Y-encoded architectural transcription factor. Mutations in SRY cause 46 XY gonadal dysgenesis with female…”
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Microsatellite-encoded domain in rodent Sry functions as a genetic capacitor to enable the rapid evolution of biological novelty by Chen, Yen-Shan, Racca, Joseph D, Sequeira, Paul W, Phillips, Nelson B, Weiss, Michael A

“…The male program of therian mammals is determined by Sry, a transcription factor encoded by the Y chromosome. Specific DNA binding is mediated by a high…”
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Structures of Eukaryotic Ribonucleotide Reductase I Provide Insights into dNTP Regulation by Xu, Hai, Faber, Catherine, Uchiki, Tomoaki, Fairman, James W., Racca, Joseph, Dealwis, Chris

“…Ribonucleotide reductase catalyzes a crucial step in de novo DNA synthesis and is allosterically controlled by relative levels of dNTPs to maintain a balanced…”
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Structures of Eukaryotic Ribonucleotide Reductase I Define Gemcitabine Diphosphate Binding and Subunit Assembly by Xu, Hai, Faber, Catherine, Uchiki, Tomoaki, Racca, Joseph, Dealwis, Chris

“…Ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates to deoxynucleoside diphosphates. Crucial for rapidly dividing cells, RNR is…”
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Human Sex Determination at the Edge of Ambiguity: Biophysical Studies of Clinical Mutations in a Master Transcription Factor by Weiss, Michael A., Chen, Yen-Shan, Racca, Joseph, Phillips, Nelson B.

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Human Sex Determination at the Edge of Ambiguity by Racca, Joseph D., Chen, Yen-Shan, Yang, Yanwu, Phillips, Nelson B., Weiss, Michael A.

“…A general problem is posed by analysis of transcriptional thresholds governing cell fate decisions in metazoan development. A model is provided by testis…”
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Inherited Human XY Sex Reversal and Gonadal Neoplasia Due to Enhanced Formation of Non-Specific Enhanceosomes by an Architectural Transcription Factor by Chen, Yen-Shan, Racca, Joseph D, Belgorosky, Alicia, Weiss, Michael Aaron

“…The development of organisms is regulated by a fine-tuned gene-regulatory network, which is driven by transcription factors (TFs). In the embryogenesis, these…”
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OR15-5 Human Sex Determination at the Edge of Ambiguity: Impaired SRY Phosphorylation Attenuates Expression of the Male Program by Chen, Yen-Shan, Racca, Joseph, Phillips, Nelson, Weiss, Michael

“…A paradox is posed by metazoan gene-regulatory networks (GRNs) that are robust yet evolvable. Insight may be obtained through studies of bistable genetic…”
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Structure-Function Relationships in Human Testis-determining Factor SRY by Racca, Joseph D., Chen, Yen-Shan, Maloy, James D., Wickramasinghe, Nalinda, Phillips, Nelson B., Weiss, Michael A.

“…Human testis determination is initiated by SRY, a Y-encoded architectural transcription factor. Mutations in SRY cause 46 XY gonadal dysgenesis with female…”
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Inherited human sex reversal due to impaired nucleocytoplasmic trafficking of SRY defines a male transcriptional threshold by Chen, Yen-Shan, Racca, Joseph D., Phillips, Nelson B., Weiss, Michael A.

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Microsatellite-encoded domain in rodent Sry functions as a genetic capacitor to enable the rapid evolution of biological novelty by Chen, Yen-Shan, Racca, Joseph D., Sequeira, Paul W., Phillips, Nelson B., Weiss, Michael A.

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Mammalian testis-determining factor SRY and the enigma of inherited human sex reversal: frustrated induced fit in a bent protein-DNA complex by Phillips, Nelson B, Racca, Joseph, Chen, Yen-Shan, Singh, Rupinder, Jancso-Radek, Agnes, Radek, James T, Wickramasinghe, Nalinda P, Haas, Elisha, Weiss, Michael A

“…Mammalian testis-determining factor SRY contains a high mobility group box, a conserved eukaryotic motif of DNA bending. Mutations in SRY cause XY gonadal…”
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SUN-712 Familial 46, XY Complete Female External Sex Development with a Non-Mosaic Inherited SRY Gene Variation by Vaiani, Elisa, Chen, Yen-Shan, Ramirez, Pablo, Baquedano, Maria Sonia, Malosetti, Maria del carmen, Racca, Joseph, Touzon, Maria Sol, Marino, Roxana, Costanzo, Mariana, Bailez, Marcela, Berensztein, Esperanza, Galuzzo, Laura, Weiss, Michael Aaron, Belgorosky, Alicia

“…Context: SRY, an architectural transcription factor containing a SOX-related high-mobility group (HMG) box, initiates testis formation in the mammalian…”
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Mammalian Testis-determining Factor SRY and the Enigma of Inherited Human Sex Reversal by Phillips, Nelson B., Racca, Joseph, Chen, Yen-Shan, Singh, Rupinder, Jancso-Radek, Agnes, Radek, James T., Wickramasinghe, Nalinda P., Haas, Elisha, Weiss, Michael A.

“…Mammalian testis-determining factor SRY contains a high mobility group box, a conserved eukaryotic motif of DNA bending. Mutations in SRY cause XY gonadal…”
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"Experiments of Nature": Structure-function Studies of an Architectural Transcription Factor: Application to Male Sex Determination by Racca, Joseph D

“…Mutations associated with disease states or developmental abnormalities can be exploited as “nature-guided” probes of structure and function. These studies are…”
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