Search Results - "Rabushko, Elizaveta"
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Clinically relevant fusion oncogenes: detection and practical implications
Published in Therapeutic Advances in Medical Oncology (01-01-2022)“…Mechanistically, chimeric genes result from DNA rearrangements and include parts of preexisting normal genes combined at the genomic junction site. Some…”
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Book Review Journal Article -
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RNA Sequencing for Personalized Treatment of Metastatic Leiomyosarcoma: Case Report
Published in Frontiers in oncology (30-08-2021)“…Uterine leiomyosarcoma (UL) is a rare malignant tumor that develops from the uterine smooth muscle tissue. Due to the low frequency and lack of sufficient data…”
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Journal Article -
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RNA Sequencing Data for FFPE Tumor Blocks Can Be Used for Robust Estimation of Tumor Mutation Burden in Individual Biosamples
Published in Frontiers in oncology (28-09-2021)“…Tumor mutation burden (TMB) is a well-known efficacy predictor for checkpoint inhibitor immunotherapies. Currently, TMB assessment relies on DNA sequencing…”
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Journal Article -
4
Experimental and Meta-Analytic Validation of RNA Sequencing Signatures for Predicting Status of Microsatellite Instability
Published in Frontiers in molecular biosciences (23-11-2021)“…Microsatellite instability (MSI) is an important diagnostic and prognostic cancer biomarker. In colorectal, cervical, ovarian, and gastric cancers, it can…”
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Journal Article -
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Experimentally Deduced Criteria for Detection of Clinically Relevant Fusion 3′ Oncogenes from FFPE Bulk RNA Sequencing Data
Published in Biomedicines (01-08-2022)“…Drugs targeting receptor tyrosine kinase (RTK) oncogenic fusion proteins demonstrate impressive anti-cancer activities. The fusion presence in the cancer is…”
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Journal Article -
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A New Approach of Detecting ALK Fusion Oncogenes by RNA Sequencing Exon Coverage Analysis
Published in Cancers (16-11-2024)“…Background: In clinical practice, various methods are used to identify ALK gene rearrangements in tumor samples, ranging from “classic” techniques, such as…”
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Journal Article -
7
RNA Sequencing for Personalized Treatment of Metastatic Leiomyosarcoma: Case Report
Published in Frontiers in oncology (01-01-2021)“…Uterine leiomyosarcoma (UL) is a rare malignant tumor that develops from the uterine smooth muscle tissue. Due to the low frequency and lack of sufficient data…”
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