Search Results - "Rabinowich, Hannah"

Autophagic degradation of active caspase-8: A crosstalk mechanism between autophagy and apoptosis by Hou, Wen, Han, Jie, Lu, Caisheng, Goldstein, Leslie A., Rabinowich, Hannah

“…Apoptotic defects endow tumor cells with survival advantages. Such defects allow the cellular stress response to take the path of cytoprotective autophagy,…”
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Involvement of Protective Autophagy in TRAIL Resistance of Apoptosis-defective Tumor Cells by Han, Jie, Hou, Wen, Goldstein, Leslie A., Lu, Caisheng, Stolz, Donna B., Yin, Xiao-Ming, Rabinowich, Hannah

“…Targeting TRAIL receptors with either recombinant TRAIL or agonistic DR4- or DR5-specific antibodies has been considered a promising treatment for cancer,…”
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Interrelated Roles for Mcl-1 and BIM in Regulation of TRAIL-mediated Mitochondrial Apoptosis by Han, Jie, Goldstein, Leslie A., Gastman, Brian R., Rabinowich, Hannah

“…The current study demonstrates a novel cross-talk mechanism between the TRAIL receptor death signaling pathway and the mitochondria. This newly identified…”
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Regulation of Mitochondrial Apoptotic Events by p53-mediated Disruption of Complexes between Antiapoptotic Bcl-2 Members and Bim by Han, Jie, Goldstein, Leslie A., Hou, Wen, Gastman, Brian R., Rabinowich, Hannah

“…Multiple mechanisms have been proposed for the mitochondrial function of p53 that are either dependent on or independent of its transcriptional activity…”
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Deregulation of Mitochondrial Membrane Potential by Mitochondrial Insertion of Granzyme B and Direct Hax-1 Cleavage by Han, Jie, Goldstein, Leslie A., Hou, Wen, Froelich, Christopher J., Watkins, Simon C., Rabinowich, Hannah

“…The cytoplasm and the nucleus have been identified as activity sites for granzyme B (GrB) following its delivery from cytotoxic lymphocyte granules into target…”
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Functional Linkage between NOXA and Bim in Mitochondrial Apoptotic Events by Han, Jie, Goldstein, Leslie A., Hou, Wen, Rabinowich, Hannah

“…NOXA is a BH3-only protein whose expression is induced by certain p53-depenent or independent apoptotic stimuli. Both NOXA and Bim are avid binders of Mcl-1,…”
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Disruption of Mcl-1·Bim Complex in Granzyme B-mediated Mitochondrial Apoptosis by Han, Jie, Goldstein, Leslie A., Gastman, Brian R., Rabinovitz, Asaf, Rabinowich, Hannah

“…Recently, we reported the identification of a novel mitochondrial apoptotic pathway for granzyme B (GrB) (Han, J., Goldstein, L. A., Gastman, B. R., Froelich,…”
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Cytolytic cells induce HMGB1 release from melanoma cell lines by Ito, Norimasa, DeMarco, Richard A., Mailliard, Robbie B., Han, Jie, Rabinowich, Hannah, Kalinski, Pawel, Stolz, Donna Beer, Zeh, Herbert J., Lotze, Michael T.

“…High mobility group box 1 (HMGB1) is one of the recently defined damage‐associated molecular pattern molecules, passively released from necrotic cells and…”
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Enhancement of tumor-TRAIL susceptibility by modulation of autophagy by Hou, Wen, Han, Jie, Lu, Caisheng, Goldstein, Leslie A., Rabinowich, Hannah

“…Autophagy has recently been recognized as an important cellular response to stress. However, the prospect of manipulating the autophagic process for the…”
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Relief of Extrinsic Pathway Inhibition by the Bid-dependent Mitochondrial Release of Smac in Fas-mediated Hepatocyte Apoptosis by Li, Shuchen, Zhao, Yongge, He, Xi, Kim, Tae-Hyoung, Kuharsky, Diane K., Rabinowich, Hannah, Chen, Jun, Du, Chunying, Yin, Xiao-Ming

“…The mitochondrial pathway is critical for the efficient execution of death receptor-initiated apoptosis in certain cell types. Questions remain as to why the…”
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A Role for Mitochondrial Bak in Apoptotic Response to Anticancer Drugs by Wang, Gui-Qiang, Gastman, Brian R., Wieckowski, Eva, Goldstein, Leslie A., Gambotto, Andrea, Kim, Tae-Hyoung, Fang, Bingliang, Rabinovitz, Asaf, Yin, Xiao-Ming, Rabinowich, Hannah

“…In the present study a clonal Jurkat cell line deficient in expression of Bak was used to analyze the role of Bak in cytochrome c release from mitochondria…”
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Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium by Mi, Zhibao, Lu, Xiaoli, Mai, Jeffrey C, Ng, Bobby G, Wang, Guiqiang, Lechman, Eric R, Watkins, Simon C, Rabinowich, Hannah, Robbins, Paul D

“…Synovial hyperplasia, resulting in erosion of cartilage and bone, represents one of the major pathologies associated with rheumatoid arthritis. To develop an…”
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Mitochondrial Lipid Alterations during Fas- and Radiation-Induced Apoptosis by Matsko, Christopher M., Hunter, Oriana C., Rabinowich, Hannah, Lotze, Michael T., Amoscato, Andrew A.

“…In the present study, we investigated the dynamic alterations in mitochondrial lipids occurring during Fas- and radiation-induced cell death. Cross-linking of…”
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Tumor's other immune targets: dendritic cells by Esche, Clemens, Lokshin, Anna, Shurin, Galina V., Gastman, Brian R., Rabinowich, Hannah, Watkins, Simon C., Lotze, Michael T., Shurin, Michael R.

“…The induction of apoptosis in T cells is one of several mechanisms by which tumors escape immune recognition. We have investigated whether tumors induce…”
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Involvement of CASP9 (caspase 9) in IGF2R/CI-MPR endosomal transport by Han, Jie, Goldstein, Leslie A., Hou, Wen, Watkins, Simon C., Rabinowich, Hannah

“…Recently, we reported that increased expression of CASP9 pro-domain, at the endosomal membrane in response to HSP90 inhibition, mediates a cell-protective…”
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Apoptosis-resistant Mitochondria in T Cells Selected for Resistance to Fas Signaling by Wang, Gui-Qiang, Gastman, Brian R., Wieckowski, Eva, Goldstein, Leslie A., Rabinovitz, Asaf, Yin, Xiao-Ming, Rabinowich, Hannah

“…Jurkat leukemic T cells are highly sensitive to the extrinsic pathways of apoptosis induced via the death receptor Fas or tumor necrosis factor-related…”
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A Complex between Atg7 and Caspase-9: A NOVEL MECHANISM OF CROSS-REGULATION BETWEEN AUTOPHAGY AND APOPTOSIS by Han, Jie, Hou, Wen, Goldstein, Leslie A, Stolz, Donna B, Watkins, Simon C, Rabinowich, Hannah

“…Several cross-talk mechanisms between autophagy and apoptosis have been identified, in which certain co-regulators are shared, allowing the same protein to…”
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Degradation of Mcl-1 by Granzyme B by Han, Jie, Goldstein, Leslie A., Gastman, Brian R., Froelich, Christopher J., Yin, Xiao-Ming, Rabinowich, Hannah

“…Recent studies have suggested that in the absence of Bid, granzyme B (GrB) can utilize an unknown alternative pathway to mediate mitochondrial apoptotic…”
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Tumor Necrosis Factor-α-promoted Expression of Bcl-2 and Inhibition of Mitochondrial Cytochrome c Release Mediate Resistance of Mature Dendritic Cells to Melanoma-induced Apoptosis by ESCHE, Clemens, SHURIN, Galina V, KIRKWOOD, John M, WANG, Gui-Qiang, RABINOWICH, Hannah, PIRTSKHALAISHVILI, Georgi, SHURIN, Michael R

“…Melanoma escapes host defenses through a variety of means, including the elimination of immune effector cells within the tumor microenvironment. We have…”
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HSP90 inhibition targets autophagy and induces a CASP9-dependent resistance mechanism in NSCLC by Han, Jie, Goldstein, Leslie A., Hou, Wen, Chatterjee, Suman, Burns, Timothy F., Rabinowich, Hannah

“…Macroautophagy/autophagy has emerged as a resistance mechanism to anticancer drug treatments that induce metabolic stress. Certain tumors, including a subset…”
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