Minimally Invasive coronary surgery compared to STernotomy coronary artery bypass grafting: The MIST trial

Minimally invasive cardiac surgery has emerged as a safe alternative to standard cardiac surgery. Minimally invasive coronary surgery (MICS CABG) was developed to allow adequate exposure and complete revascularization in CABG from a small thoracotomy incision without cardiopulmonary bypass. Multiple...

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Bibliographic Details
Published in:	Contemporary clinical trials Vol. 78; pp. 140 - 145
Main Authors:	Guo, Ming Hao, Wells, George A., Glineur, David, Fortier, Jacqueline, Davierwala, Piroze M., Kikuchi, Keita, Lemma, Massimo G., Mishra, Yugal K., McGinn, Joseph, Ramchandani, Mahesh, Rabindra, Prem, Nambala, Sathyaki, Chiu, Kuan Ming, Kiaii, Bob, Gibson, Sarah, Ruel, Marc
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-03-2019
Subjects:	Adolescent Adult Aged Coronary Artery Bypass - methods Emotions Female Humans Length of Stay Male Mental Health Middle Aged Minimally Invasive Surgical Procedures - methods Multicenter Studies as Topic Operative Time Physical Functional Performance Postoperative Complications - epidemiology Prospective Studies Quality of Life Randomized Controlled Trials as Topic Sternotomy - methods Thoracotomy - methods Young Adult
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Summary:	Minimally invasive cardiac surgery has emerged as a safe alternative to standard cardiac surgery. Minimally invasive coronary surgery (MICS CABG) was developed to allow adequate exposure and complete revascularization in CABG from a small thoracotomy incision without cardiopulmonary bypass. Multiple studies have reported significant shorter length of hospital stay and earlier postoperative physical recovery for MICS CABG patients when compared to sternotomy CABG patients. However, there have been no convincing clinical trials that demonstrate improvement in post-operative quality of life for patients who undergo MICS CABG. The Minimally Invasive Coronary Surgery compared to Sternotomy Coronary Artery Bypass Grafting (MIST) trial is a multi-centered, prospective randomized controlled trial that compares the quality of life and recovery in the early post-operative period between patients undergoing MICS CABG versus patients undergoing sternotomy CABG. Patients will be randomized either to the MICS CABG group or the sternotomy CABG group, and the target enrollment is 88 patients per group. The primary outcome is quality of life assessment performed by SF-36 questionnaire at 1 month. The MIST trial is the first prospective study that compares the quality of life between MICS CABG and sternotomy CABG patients. The results of this trial may enhance the procedural desirability of MICS CABG by patients and provide an incentive for surgeons and institutions to increase the availability of MICS CABG in suitable patients.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-3 ObjectType-Feature-4 ObjectType-Undefined-1 content type line 23
ISSN:	1551-7144 1559-2030
DOI:	10.1016/j.cct.2019.01.006