A new eye gel containing sodium hyaluronate and xanthan gum for the management of post-traumatic corneal abrasions

A new eye gel containing sodium hyaluronate and xanthan gum for the management of post-traumatic corneal abrasions

The aim of this study was to investigate the effects of an ophthalmic gel containing sodium hyaluronate and xanthan gum in addition to the antibiotic netilmicin in the management of traumatic corneal abrasions. PATIENTS WITH TRAUMATIC CORNEAL ABRASIONS WERE RANDOMLY TREATED AS FOLLOWS: Group A (n =...

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Bibliographic Details
Published in:Clinical ophthalmology (Auckland, N.Z.) Vol. 6; no. default; pp. 727 - 731
Main Authors: Faraldi, Francesco, Papa, Vincenzo, Santoro, Debora, Rasà, Daria, Mazza, Annamaria L, Rabbione, Maria M, Russo, Simona
Format: Journal Article
Language:English
Published: New Zealand Dove Medical Press Limited 01-01-2012
Taylor & Francis Ltd
Dove Press
Dove Medical Press
Subjects:
Abrasions
Antibiotics
Care and treatment
Cornea
corneal abrasion
Dosage and administration
Eye
Injuries
netilmicin
Ophthalmic drugs
Ophthalmology
Original Research
patching
Sodium
wound healing
xanthan gum
Italy
corneal abrasion
xanthan gum
wound healing
patching
netilmicin
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Summary:The aim of this study was to investigate the effects of an ophthalmic gel containing sodium hyaluronate and xanthan gum in addition to the antibiotic netilmicin in the management of traumatic corneal abrasions. PATIENTS WITH TRAUMATIC CORNEAL ABRASIONS WERE RANDOMLY TREATED AS FOLLOWS: Group A (n = 20) with an occlusive patching for 12 hours plus one drop of an eye gel containing 0.15% sodium hyaluronate, 1% xanthan gum and 0.3% netilmicin qid for 5 days; and Group B (n = 20) with an occlusive patching for 2-3 days plus one application of 0.3% netilmicin ophthalmic ointment qid for 5 days. All patients were evaluated after the third and seventh day by slit-lamp examination, fluorescein staining, and corneal defect photograph in order to assess corneal re-epithelialization. Conjunctival hyperaemia, lid oedema, subjective symptoms of discomfort, and conjunctival swabs were also evaluated. No statistically significant difference was observed between the groups in terms of the extent of corneal healing after 3 days of treatment. Both treatments were also highly effective in decreasing the erosion score and the conjunctival hyperemia (P < 0.0001, P < 0.005, respectively) without any significant difference between the two types of treatment. Subjective symptoms of discomfort and conjunctival swabs were also evaluated. In the management of traumatic corneal abrasions, the administration of an eye gel containing sodium hyaluronate and xanthan gum is able to reduce the length of occlusive patching. In addition, the presence of netilmicin guarantees good antibiotic prophylaxis during the wound repair process.
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ISSN:1177-5483
1177-5467
1177-5483
DOI:10.2147/opth.s31776