Search Results - "Rabbani, Piul S"

The Nrf2/Keap1/ARE Pathway and Oxidative Stress as a Therapeutic Target in Type II Diabetes Mellitus by Ceradini, Daniel J., Rabbani, Piul S., Rifkin, William J., David, Joshua A.

“…Despite improvements in awareness and treatment of type II diabetes mellitus (TIIDM), this disease remains a major source of morbidity and mortality worldwide,…”
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Dysregulation of Nrf2/Keap1 Redox Pathway in Diabetes Affects Multipotency of Stromal Cells by Rabbani, Piul S, Soares, Marc A, Hameedi, Sophia G, Kadle, Rohini L, Mubasher, Adnan, Kowzun, Maria, Ceradini, Daniel J

“…The molecular and cellular level reaches of the metabolic dysregulations that characterize diabetes are yet to be fully discovered. As mechanisms underlying…”
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Amniotic fluid-derived multipotent stromal cells drive diabetic wound healing through modulation of macrophages by Subhan, Bibi S, Kwong, Jennifer, Kuhn, Joseph F, Monas, Arie, Sharma, Sonali, Rabbani, Piul S

“…Cutaneous wounds in patients with diabetes exhibit impaired healing due to physiological impediments and conventional care options are severely limited…”
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Molecular Signature Associated With Acute Rejection in Vascularized Composite Allotransplantation by Cassidy, Michael F, Doudican, Nicole A, Frazzette, Nicholas, Rabbani, Piul S, Carucci, John A, Gelb, Bruce E, Rodriguez, Eduardo D, Lu, Catherine P, Ceradini, Daniel J

“…A deeper understanding of acute rejection in vascularized composite allotransplantation is paramount for expanding its utility and longevity. There remains a…”
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Evolution of a Plastic Surgery Summer Research Program: Lessons Learned from Programmatic Evaluation and Quality Enhancement by Alfonso, Allyson R., Berman, Zoe P., Diep, Gustave K., Lee, Jasmine, Ramly, Elie P., Diaz-Siso, J. Rodrigo, Rodriguez, Eduardo D., Rabbani, Piul S.

“…Early surgical exposure and research fellowships can influence medical students' specialty choice, increase academic productivity, and impact residency match…”
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Nrf2-activating Therapy Accelerates Wound Healing in a Model of Cutaneous Chronic Venous Insufficiency by Kuhn, Joseph, Sultan, Darren L., Waqas, Bukhtawar, Ellison, Trevor, Kwong, Jennifer, Kim, Camille, Hassan, Absara, Rabbani, Piul S., Ceradini, Daniel J.

“…BACKGROUNDChronic venous insufficiency (CVI) stems from venous hypertension, extravasation of blood, and iron-rich skin deposits. The latter is central to…”
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Novel lipoproteoplex delivers Keap1 siRNA based gene therapy to accelerate diabetic wound healing by Rabbani, Piul S, Zhou, Anna, Borab, Zachary M, Frezzo, Joseph A, Srivastava, Nikita, More, Haresh T, Rifkin, William J, David, Joshua A, Berens, Samuel J, Chen, Raymond, Hameedi, Sophia, Junejo, Muhammad H, Kim, Camille, Sartor, Rita A, Liu, Che F, Saadeh, Pierre B, Montclare, Jin K, Ceradini, Daniel J

“…Abstract Therapeutics utilizing siRNA are currently limited by the availability of safe and effective delivery systems. Cutaneous diseases, specifically ones…”
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Ex Vivo Major Histocompatibility Complex I Knockdown Prolongs Rejection-free Allograft Survival by Chang, Jessica B., Rifkin, William J., Soares, Marc A., Duckworth, April, Rao, Nakul, Low, Yee Cheng, Massie, Jonathan P., Rabbani, Piul S., Saadeh, Pierre B., Ceradini, Daniel J.

“…BACKGROUND:Widespread application of vascularized composite allotransplantation (VCA) is currently limited by the required lifelong systemic immunosuppression…”
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Keratinocyte-Macrophage Crosstalk by the Nrf2/Ccl2/EGF Signaling Axis Orchestrates Tissue Repair by Villarreal-Ponce, Alvaro, Tiruneh, Melat Worku, Lee, Jasmine, Guerrero-Juarez, Christian F., Kuhn, Joseph, David, Joshua A., Dammeyer, Kristen, Mc Kell, Renee, Kwong, Jennifer, Rabbani, Piul S., Nie, Qing, Ceradini, Daniel J.

“…Unveiling the molecular mechanisms underlying tissue regeneration provides new opportunities to develop treatments for diabetic ulcers and other chronic skin…”
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Targeted Nrf2 activation therapy with RTA 408 enhances regenerative capacity of diabetic wounds by Rabbani, Piul S., Ellison, Trevor, Waqas, Bukhtawar, Sultan, Darren, Abdou, Salma, David, Joshua A, Cohen, Joshua M., Gomez-Viso, Alejandro, Lam, Gretl, Kim, Camille, Thomson, Jennifer, Ceradini, Daniel J.

“…Though unmitigated oxidative stress in diabetic chronic non-healing wounds poses a major therapeutic challenge, currently, there are no effective…”
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Restoration of Nrf2 Signaling Normalizes the Regenerative Niche by Soares, Marc A, Cohen, Oriana D, Low, Yee Cheng, Sartor, Rita A, Ellison, Trevor, Anil, Utkarsh, Anzai, Lavinia, Chang, Jessica B, Saadeh, Pierre B, Rabbani, Piul S, Ceradini, Daniel J

“…Chronic hyperglycemia impairs intracellular redox homeostasis and contributes to impaired diabetic tissue regeneration. The Keap1/Nrf2 pathway is a critical…”
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594-P: Human Nrf2-Active Multipotent Stromal Cell Exosomes Promote Tissue Repair in a Wound Model of Type 2 Diabetes by KUHN, JOSEPH, HASSAN, ABSARA, SHARMA, SONALI, KWONG, JENNIFER, RAHMAN, MONTAHA, ADAM, SALMA, LEE, JASMINE, VILLARREAL PONCE, ALVARO P., RABBANI, PIUL S.

“…Exosomes, nanosized extracellular vesicles, may be key to translating multipotent stromal cell (MSC) therapy to the bedside. We previously found that nuclear…”
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Bone Tissue Engineering Strategies for Alveolar Cleft: Review of Preclinical Results and Guidelines for Future Studies by Park, Jenn J., Rochlin, Danielle H., Parsaei, Yassmin, Shetye, Pradip R., Witek, Lukasz, Leucht, Philipp, Rabbani, Piul S., Flores, Roberto L.

“…The current standard of care for an alveolar cleft defect is an autogenous bone graft, typically from the iliac crest. Given the limitations of alveolar bone…”
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Behind the Scenes of Extracellular Vesicle Therapy for Skin Injuries and Disorders by Subhan, Bibi S, Ki, Michelle, Verzella, Alexandra, Shankar, Shruthi, Rabbani, Piul S

“…Skin wounds and disorders compromise the protective functions of skin and patient quality of life. Although accessible on the surface, they are challenging to…”
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71-OR: Dynamic Nrf2 Expression in Cutaneous Wounds Regulates Skin Reepithelialization by VILLARREAL PONCE, ALVARO P., DAVID, JOSHUA A., TIRUNEH, MELAT WORKU, ABDOU, SALMA, SULTAN, DARREN, KWONG, JENNIFER, KUHN, JOSEPH, RABBANI, PIUL S., CERADINI, DANIEL

“…Diabetic ulcers are chronic cutaneous complications that amount to more than $50M in healthcare costs and are the leading cause of lower extremity amputations…”
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623-P: Impaired Nrf2 Function Corresponds with Delayed Wound Healing in Diabetes by KUHN, JOSEPH, DAVID, JOSHUA A., VILLARREAL PONCE, ALVARO P., ABDOU, SALMA, SULTAN, DARREN, KWONG, JENNIFER, RABBANI, PIUL S., CERADINI, DANIEL

“…Imbalance in the production of reactive oxygen species predisposes diabetic patients to delayed wound healing, but treatments that directly address this…”
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Ex vivo allotransplantation engineering: Delivery of mesenchymal stem cells prolongs rejection‐free allograft survival by Soares, Marc A., Massie, Jonathan P., Rifkin, William J., Rao, Nakul, Duckworth, April M., Park, Chin, Kadle, Rohini L., David, Joshua A., Rabbani, Piul S., Ceradini, Daniel J.

“…Current pharmacologic regimens in transplantation prevent allograft rejection through systemic recipient immunosuppression but are associated with severe…”
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Minimally and Non-invasive Approaches to Rejection Identification in Vascularized Composite Allotransplantation by Stead, Thor S., Brydges, Hilliard T., Laspro, Matteo, Onuh, Ogechukwu C., Chaya, Bachar F., Rabbani, Piul S., Lu, Catherine P., Ceradini, Daniel J., Gelb, Bruce E., Rodriguez, Eduardo D.

“…OBJECTIVERejection is common and pernicious following Vascularized Composite Allotransplantation (VCA). Current monitoring and diagnostic modalities include…”
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In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model by Rabbani, Piul S, Abdou, Salma A, Sultan, Darren L, Kwong, Jennifer, Duckworth, April, Ceradini, Daniel J

“…The generation of reactive oxygen species (ROS) is a hallmark of inflammatory processes, but in excess, oxidative stress is widely implicated in various…”
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Critical Regulation of Angiogenesis by Nrf2 Signaling Is Absent in Diabetic Wound Healing by Rabbani, Piul S, David, Joshua A, Sultan, Darren L, Villarreal-Ponce, Alvaro P, Kwong, Jennifer, Lee, Jasmine, Shen, Chen, Abdou, Salma A, Ceradini, Daniel

“…Diabetes-associated ulcers account for 11% of non-traumatic limb and extremity amputations. Tailoring therapies for chronic diabetic wounds is challenging,…”
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