Search Results - "Rabal, Maria Pilar Marcos"
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Comparison of histological delineations of medial temporal lobe cortices by four independent neuroanatomy laboratories
Published in Hippocampus (01-05-2024)“…The medial temporal lobe (MTL) cortex, located adjacent to the hippocampus, is crucial for memory and prone to the accumulation of certain neuropathologies…”
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Postmortem imaging reveals patterns of medial temporal lobe vulnerability to tau pathology in Alzheimer’s disease
Published in Nature communications (05-06-2024)“…Our current understanding of the spread and neurodegenerative effects of tau neurofibrillary tangles (NFTs) within the medial temporal lobe (MTL) during the…”
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Neuropeptides in the developing human hippocampus under hypoxic–ischemic conditions
Published in Journal of anatomy (01-10-2021)“…The perinatal period, sensitive for newborn survival, is also one of the most critical moments in human brain development. Perinatal hypoxia due to reduced…”
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Ex vivo , in situ perfusion protocol for human brain fixation compatible with microscopy, MRI techniques, and anatomical studies
Published in Frontiers in neuroanatomy (23-03-2023)“…We present a method for human brain fixation based on simultaneous perfusion of 4% paraformaldehyde through carotids after a flush with saline. The left…”
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3D Mapping of TAU Neurofibrillary Tangle Pathology in the Human Medial Temporal Lobe
Published in 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI) (01-04-2020)“…Tau protein neurofibrillary tangles (NFT) are linked to neuronal and synaptic loss and cognitive decline in Alzheimer's disease (AD) and related dementias. In…”
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Conference Proceeding -
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Building an Ex Vivo Atlas of the Earliest Brain Regions Affected by Alzheimer's Disease Pathology
Published in 2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI) (01-04-2020)“…Earliest neuropathological changes in Alzheimer's Disease (AD) emerge in the medial temporal lobe (MTL). In order for MRI biomarkers to detect changes linked…”
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Conference Proceeding -
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Using an ex vivo MRI atlas of the human medial temporal lobe to characterize the 3D distribution of neurofibrillary tangle burden across histologically defined subregions
Published in Alzheimer's & dementia (01-12-2023)“…Background Accumulation of tau neurofibrillary tangles (NFT) in the medial temporal lobe (MTL) is an early pathological change associated with…”
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Developing an anatomically valid segmentation protocol for early tau regions: the anterior medial temporal lobe cortices
Published in Alzheimer's & dementia (01-12-2023)“…Background The anterior portion of the medial temporal lobe (MTL) is one of the earliest regions showing tau deposition in Alzheimer’s disease (AD) and hence a…”
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Unfolding the medial temporal lobe to characterize neurodegeneration due to Alzheimer's disease pathology
Published in Alzheimer's & dementia (01-12-2021)“…Background Measurements of medial temporal lobe (MTL) neurodegeneration derived using MRI have been shown to be sensitive to changes during the early stages of…”
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Ex vivo MRI atlas of the human medial temporal lobe: characterizing neurodegeneration due to tau pathology
Published in Acta neuropathologica communications (24-10-2021)“…Tau neurofibrillary tangle (NFT) pathology in the medial temporal lobe (MTL) is closely linked to neurodegeneration, and is the early pathological change…”
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Application of histopathologically derived 3D tau burden map as in‐vivo region of interest for biomarker analysis
Published in Alzheimer's & dementia (01-12-2021)“…Background Quantitative three‐dimensional maps of tau neurofibrillary tangles (NFT) burden derived from dense serial histology have potential application for…”
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Novel ex vivo MRI atlas of the medial temporal lobe can be used to characterize structural changes due to Alzheimer’s disease pathology
Published in Alzheimer's & dementia (01-12-2020)“…Background Finding effective biomarkers that can support early‐stage clinical trials is a major challenge in Alzheimer’s Disease (AD). MRI measures of…”
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Associations of phosphorylated tau pathology with whole‐hemisphere ex vivo morphometry in 7 tesla MRI
Published in Alzheimer's & dementia (01-06-2023)“…Introduction Neurodegenerative disorders are associated with different pathologies that often co‐occur but cannot be measured specifically with in vivo…”
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Optimized extraction of the medial temporal lobe for postmortem MRI based on custom 3D printed molds
Published in Alzheimer's & dementia (01-12-2020)“…Background Structural magnetic resonance imaging (MRI) biomarkers are important for early detection of Alzheimer’s Disease (AD). However, atrophy measures can…”
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Optimized extraction of the medial temporal lobe for postmortem MRI based on custom 3D printed molds: Neuroimaging / New imaging methods
Published in Alzheimer's & dementia (01-12-2020)Get full text
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High‐resolution postmortem MRI reveals TDP‐43 association with medial temporal lobe subregional atrophy
Published in Alzheimer's & dementia (01-12-2020)“…Background The medial temporal lobe (MTL) is a hotspot of different neurodegenerative pathologies, and recent studies have shown associations of severity of…”
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Improved Segmentation of Deep Sulci in Cortical Gray Matter Using a Deep Learning Framework Incorporating Laplace's Equation
Published 01-03-2023“…When developing tools for automated cortical segmentation, the ability to produce topologically correct segmentations is important in order to compute…”
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