Search Results - "Raaphorst, G P"

Fitting the linear-quadratic model to detailed data sets for different dose ranges by Garcia, L M, Leblanc, J, Wilkins, D, Raaphorst, G P

“…Survival curve behaviour and degree of correspondence between the linear-quadratic (LQ) model and experimental data in an extensive dose range for high dose…”
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Low-Dose Ionizing Radiation Decreases the Frequency of Neoplastic Transformation to a Level below the Spontaneous Rate in C3H 10T1/2 Cells by Azzam, E. I., de Toledo, S. M., Raaphorst, G. P., Mitchel, R. E. J.

“…We have previously shown that chronic exposure of plateau-phase C3H 10T1/2 cells to 60 Co γ radiation at doses as low as 10 cGy protected the cells against…”
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Examining the non-homologous repair process following cisplatin and radiation treatments by Myint, W. K., Ng, Cheng, Raaphorst, G. P.

“…Purpose : To investigate the extent of non-homologous end-joining (NHEJ) in the mechanism of cisplatin radiosensitization. Materials and methods :…”
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Adaptive response and its variation in human normal and tumour cells by BOYDEN, G. P. RAAPHORST, S.

“…Purpose: Adaptive responses in mammalian cells appear to be highly variable. Six human cell lines were used to evaluate whether adaptive responsecould be…”
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Radiation-Induced Adaptive Response for Protection against Micronucleus Formation and Neoplastic Transformation in C3H 10T1/2 Mouse Embryo Cells by Azzam, E. I., Raaphorst, G. P., Mitchel, R. E. J.

“…We have monitored the end points of cellular survival, micronucleus formation and neoplastic transformation frequency to assess adaptation to ionizing…”
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A Comparison of Response to Cisplatin, Radiation and Combined Treatment for Cells Deficient in Recombination Repair Pathways by RAAPHORST, G. P, LEBLANC, J. Maude, LI, L. F

“…The responses of cells with mutated DNA repair pathways were compared for cisplatin, radiation and combination treatments. The knockout of the nonhomologous…”
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Evaluation of Adaptive Responses to Cisplatin in Normal and Mutant Cell Lines with Mutations in Recombination Repair Pathways by RAAPHORST, G. P, LI, L. F, YANG, D. P

“…Cell lines mutant in specific DNA repair pathways were used to determine if these pathways are involved in adaptive responses. For these studies, the effect of…”
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Evaluation of Recombination Repair Pathways in Thermal Radiosensitization by Raaphorst, G. P., Maude-Leblanc, J., Li, L.

“…Raaphorst, G. P., Maude-Leblanc, J. and Li, L. Evaluation of Recombination Repair Pathways in Thermal Radiosensitization. Radiat. Res. 161, 215–218 (2004)…”
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Adaptive responses in human glioma cells assessed by clonogenic survival and DNA strand break analysis by Smith, D. M., Raaphorst, G. P.

“…Purpose: Human gliomas are known to be radioresistant and the aim was to determine if this resistance in part could be due to an adaptive response. Materials…”
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Long duration mild temperature hyperthermia and brachytherapy by Armour, E P, Raaphorst, G P

“…Combining long duration mild temperature hyperthermia (LDMH) and low dose-rate (LDR) brachytherapy to enhance therapeutic killing of cancer cells was proposed…”
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Response to pulsed dose rate and low dose rate irradiation with and without mild hyperthermia using human breast carcinoma cell lines by Niedbala, M, McNamee, J P, Raaphorst, G P

“…The purpose of this study was to establish whether a pulsed dose rate (PDR) treatment of 1.5 Gy given every 3 h in combination with 41 degrees C mild…”
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Cisplatin sensitization by concurrent mild hyperthermia in parental and mutant cell lines deficient in homologous recombination and non-homologous endjoining repair by Raaphorst, G P, Li, L F, Yang, D P, LeBlanc, J-M

“…The effect of mild hyperthermia on cisplatin sensitization was examined in two cell line pairs, CHO parental AA8 and irsISF, an XRCC3 mutant (deficient in…”
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Comparison of repair and rejoining fidelity between two isogenic human ovarian carcinoma cell lines by Howley, H. E. Abbott, Raaphorst, G. P.

“…Purpose : The difference in radiosensitivity between two isogenic tumour cell lines was evaluated to determine whether factors such as sublethal and…”
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Prediction of radiosensitivity by measurement of X-ray induced apoptosis in human blood using the comet assay by Kizilian-Martel, N, Wilkins, R C, Mclean, J R, Malone, S, Raaphorst, G P

“…The aim of this work was to determine whether levels of radiation-induced apoptosis in human peripheral leukocytes could be used as a predictor of…”
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Modulation of radiation-induced strand break repair by cisplatin in mammalian cells by DOLLING, J.-A, BOREHAM, D. R, BROWN, D. L, MITCHEL, R. E. J, RAAPHORST, G. P

“…Purpose: To investigate the repair of ionizing radiation-induced DNA lesions in human skin fibroblasts in the presence of cisplatin-DNA adducts and to…”
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Correlation between normal tissue complications and in vitro radiosensitivity of skin fibroblasts derived from radiotherapy patients treated for variety of tumors by Alsbeih, G, Malone, S, Lochrin, C, Girard, A, Fertil, B, Raaphorst, G P

“…To assess the relationship between fibroblast intrinsic radiosensitivity in vitro and late reactions of normal tissues in patients treated by definitive…”
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Evidence for adaptive response and implication in pulse-simulated low-dose-rate radiotherapy by Raaphorst, G P, Ng, C E, Smith, D, Niedbala, M

“…Pulsed-dose-rate (PDR) brachytherapy as a substitute for continuous low-dose-rate (LDR) brachytherapy has a number of clinical advantages. However, early…”
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Equivalence of Pulsed-Dose-Rate to Low-Dose-Rate Irradiation in Tumor and Normal Cell Lines by Niedbala, M., Alsbeih, G., Ng, C. E., Raaphorst, G. P.

“…Niedbala, M., Alsbeih, G., Ng, C. E. and Raaphorst, G. P. Equivalence of Pulsed-Dose-Rate to Low-Dose-Rate Irradiation in Tumor and Normal Cell Lines. To…”
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Changes in muscle blood flow distribution during hyperthermia by Akyürekli, D, Gerig, L H, Raaphorst, G P

“…Blood flow is a critical parameter for obtaining satisfactory temperature distributions during clinical hyperthermia. This study examines the changes in blood…”
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Severe normal tissue complication correlates with increased in vitro fibroblast radiosensitivity in radical prostate radiotherapy: A case report by Raaphorst, G.P., Malone, S., Szanto, J., Gray, R.

“…The radiation responses of fibroblasts taken from four patients undergoing radiotherapy for prostate cancer were evaluated in vitro. One patient exhibited a…”
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