Search Results - "Raaphorst, FM"

Self-renewal of hematopoietic and leukemic stem cells: a central role for the Polycomb-group gene Bmi-1 by Raaphorst, Frank M.

“…Self-renewal of hematopoietic stem cells is vital for the sustained daily production of blood cells. Two recent studies have shown that the Polycomb-group gene…”
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The role of Homeobox genes in normal hematopoiesis and hematological malignancies by VAN OOSTVEEN, J. W, BIJL, J. J, RAAPHORST, F. M, WALBOOMERS, J. J. M, MEIJER, C. J. L. M

“…In the last decade it has become clear that homeobox containing genes (HOX genes) not only play a significant role in regulating body formation, but in…”
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Deregulated expression of Polycomb-group oncogenes in human malignant lymphomas and epithelial tumors by Raaphorst, Frank M

“…Genes belonging to the Polycomb-group (PcG) are epigenetic gene silencers with a vital role in the maintenance of cell identity. They contribute to regulation…”
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Coexpression of BMI-1 and EZH2 polycomb-group proteins is associated with cycling cells and degree of malignancy in B-cell non-Hodgkin lymphoma by van Kemenade, Folkert J., Raaphorst, Frank M., Blokzijl, Tjasso, Fieret, Elly, Hamer, Karien M., Satijn, David P.E., Otte, Arie P., Meijer, Chris J.L.M.

“…Polycomb-group (PcG) proteins, such as BMI-1 and EZH2, form multimeric gene-repressing complexes involved in axial patterning, hematopoiesis, and cell cycle…”
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Poorly Differentiated Breast Carcinoma is Associated with Increased Expression of the Human Polycomb Group EZH2 Gene by Raaphorst, Frank M., Meijer, Chris J.L.M., Fieret, Elly, Blokzijl, Tjasso, Mommers, Ellen, Buerger, Horst, Packeisen, Jens, Sewalt, Richard A.B., Ottet, Arie P., van Diest, Paul J.

“…Polycomb group (PcG) genes contribute to the maintenance of cell identity, cell cycle regulation, and oncogenesis. We describe the expression of five PcG genes…”
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Unique Polycomb Gene Expression Pattern in Hodgkin's Lymphoma and Hodgkin's Lymphoma-Derived Cell Lines by Dukers, Danny F., van Galen, Joost C., Giroth, Cindy, Jansen, Patty, Sewalt, Richard G.A.B., Otte, Arie P., Kluin-Nelemans, Hanneke C., Meijer, Chris J.L.M., Raaphorst, Frank M.

“…Human Polycomb-group (PcG) genes play a crucial role in the regulation of embryonic development and regulation of the cell cycle and hematopoiesis. PcG genes…”
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The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma by Visser, Hein P. J., Gunster, Marco J., Kluin‐Nelemans, Hanneke C., Manders, Erik M. M., Raaphorst, Frank M., Meijer, Chris J. L. M., Willemze, Roel, Otte, Arie P.

“…Polycomb group (PcG) proteins are involved in the stable transmittance of the repressive state of their gene targets throughout the cell cycle. Mis‐expression…”
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Increased Expression of the EZH2 Polycomb Group Gene in BMI-1-Positive Neoplastic Cells during Bronchial Carcinogenesis by Breuer, Roderick H.J., Snijders, Peter J.F., Smit, Egbert F., Sutedja, Thomas G., Sewalt, Richard G.A.B., Otte, Arie P., van Kemenade, Folkert J., Postmus, Pieter E., Meijer, Chris J.L.M., Raaphorst, Frank M.

“…Polycomb group (PcG) genes are responsible for maintenance of cellular identity and contribute to regulation of the cell cycle. Recent studies have identified…”
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Polycomb-group genes as regulators of mammalian lymphopoiesis by Raaphorst, Frank M., Otte, Arie P., Meijer, Chris J.L.M.

“…Polycomb proteins form DNA-binding protein complexes with gene-suppressing activity. They maintain cell identity but, also, contribute to the regulation of…”
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Coexpression of BMI-1 and EZH2 Polycomb Group Genes in Reed-Sternberg Cells of Hodgkin’s Disease by Raaphorst, Frank M., van Kemenade, Folkert J., Blokzijl, Tjasso, Fieret, Elly, Hamer, Karien M., Satijn, David P.E., Otte, Arie P., Meijer, Chris J.L.M.

“…The human BMI-1 and EZH2 polycomb group (PcG) proteins are constituents of two distinct complexes of PcG proteins with gene regulatory activity. PcG proteins…”
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Expression of the p16(INK4a) gene product, methylation of the p16(INK4a) promoter region and expression of the polycomb-group gene BMI-1 in squamous cell lung carcinoma and premalignant endobronchial lesions by Breuer, R H J, Snijders, P J F, Sutedja, G T, Sewalt, R G A B, Otte, A P, Postmus, P E, Meijer, C J L M, Raaphorst, F M, Smit, E F

“…It is generally assumed that squamous cell carcinoma develops in a stepwise manner from normal bronchial epithelium towards cancer by the accumulation of…”
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Distinct expression patterns of polycomb oncoproteins and their binding partners during the germinal center reaction by van Galen, Joost C., Dukers, Danny F., Giroth, Cindy, Sewalt, Richard G. A. B., Otte, Arie P., Meijer, Chris J. L. M., Raaphorst, Frank M.

“…Polycomb group (PcG) genes encode two chromatin‐binding protein complexes, the PRC1 and the PRC2 PcG complexes, which are essential for the maintenance of cell…”
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Of mice, flies, and man: the emerging role of polycomb-group genes in human malignant lymphomas by Raaphorst, Frank M

“…Genes belonging to the Polycomb group (PcG) are responsible for the maintenance of cell identity and are directly involved in epigenetic gene silencing. They…”
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Distinct BMI-1 and EZH2 Expression Patterns in Thymocytes and Mature T Cells Suggest a Role for Polycomb Genes in Human T Cell Differentiation by Raaphorst, Frank M, Otte, Arie P, van Kemenade, Folkert J, Blokzijl, Tjasso, Fieret, Elly, Hamer, Karien M, Satijn, David P. E, Meijer, Chris J. L. M

“…BMI-1 and EZH2 Polycomb-group (PcG) proteins belong to two distinct protein complexes involved in the regulation of hematopoiesis. Using unique PcG-specific…”
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Cutting Edge: Polycomb Gene Expression Patterns Reflect Distinct B Cell Differentiation Stages in Human Germinal Centers by Raaphorst, Frank M, van Kemenade, Folkert J, Fieret, Elly, Hamer, Karien M, Satijn, David P. E, Otte, Arie P, Meijer, Chris J. L. M

“…Polycomb group (Pc-G) proteins regulate homeotic gene expression in Drosophila, mouse, and humans. Mouse Pc-G proteins are also essential for adult…”
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Site-Specific Expression of Polycomb-Group Genes Encoding the HPC-HPH/PRC1 Complex in Clinically Defined Primary Nodal and Cutaneous Large B-Cell Lymphomas by Raaphorst, Frank M., Vermeer, Maarten, Fieret, Elly, Blokzijl, Tjasso, Dukers, Danny, Sewalt, Richard G.A.B., Otte, Arie P., Willemze, Rein, Meijer, Chris J.L.M.

“…Polycomb-group (PcG) genes preserve cell identity by gene silencing, and contribute to regulation of lymphopoiesis and malignant transformation. We show that…”
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Ig Heavy Chain Third Complementarity Determining Regions (H CDR3s) After Stem Cell Transplantation Do Not Resemble the Developing Human Fetal H CDR3s in Size Distribution and Ig Gene Utilization by Gokmen, Erhan, Raaphorst, Frank M., Boldt, David H., Teale, Judy M.

“…Previous studies have suggested that the B-cell repertoire after stem cell transplantation resembles the developing repertoire in the fetus. Fetal and adult…”
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Bone Marrow Transplantation, Fetal B-Cell Repertoire Development, and the Mechanism of Immune Reconstitution by Raaphorst, F.M.

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Reconstitution of the B cell repertoire after bone marrow transplantation does not recapitulate human fetal development by RAAPHORST, F. M

“…Immune reconstitution during bone marrow transplantation has been proposed to produce a fetal-type immune system. This characteristic may contribute to the…”
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Differential expression of human Polycomb group proteins in various tissues and cell types by Gunster, Marco J., Raaphorst, Frank M., Hamer, Karien M., den Blaauwen, Jan L., Fieret, Elly, Meijer, Chris J.L.M., Otte, Arie P.

“…Polycomb group proteins are involved in the maintenance of cellular identity. As multimeric complexes they repress cell type‐specific sets of target genes. One…”
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