Search Results - "Raap, Anton K"

Up-converting phosphor reporters for nucleic acid microarrays by Tanke, Hans J, van de Rijke, Frans, Zijlmans, Henry, Li, Shang, Vail, Tim, Raap, Anton K, Niedbala, R. Sam

“…An important application of robotically spotted DNA microarrays is the monitoring of RNA expression levels. A clear limitation of this technology is the…”
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Non-random mtDNA segregation patterns indicate a metastable heteroplasmic segregation unit in m.3243A>G cybrid cells by Raap, Anton K, Jahangir Tafrechi, Roshan S, van de Rijke, Frans M, Pyle, Angela, Wählby, Carolina, Szuhai, Karoly, Ravelli, Raimond B G, de Coo, René F M, Rajasimha, Harsha K, Nilsson, Mats, Chinnery, Patrick F, Samuels, David C, Janssen, George M C

“…Many pathogenic mitochondrial DNA mutations are heteroplasmic, with a mixture of mutated and wild-type mtDNA present within individual cells. The severity and…”
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Array-Based Comparative Genomic Hybridization Analysis Reveals Recurrent Chromosomal Alterations and Prognostic Parameters in Primary Cutaneous Large B-Cell Lymphoma by DIJKMAN, Remco, TENSEN, Cornelis P, VERMEER, Maarten H, JORDANOVA, Ekaterina S, KNIJNENBURG, Jeroen, HOEFNAGEL, Juliette J, MULDER, Aata, ROSENBERG, Carla, RAAP, Anton K, WILLEMZE, Rein, SZUHAI, Karoly

“…To evaluate the clinical relevance of genomic aberrations in primary cutaneous large B-cell lymphoma (PCLBCL). Skin biopsy samples of 31 patients with a PCLBCL…”
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Cancer-associated mutations in chromatin remodeler hSNF5 promote chromosomal instability by compromising the mitotic checkpoint by Vries, Robert G J, Bezrookove, Vladimir, Zuijderduijn, Lobke M P, Kia, Sima Kheradmand, Houweling, Ada, Oruetxebarria, Igor, Raap, Anton K, Verrijzer, C Peter

“…The hSNF5 subunit of human SWI/SNF ATP-dependent chromatin remodeling complexes is a tumor suppressor that is inactivated in malignant rhabdoid tumors (MRTs)…”
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Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats by Zijlmans, J M, Martens, U M, Poon, S S, Raap, A K, Tanke, H J, Ward, R K, Lansdorp, P M

“…The ultra-long telomeres that have been observed in mice are not in accordance with the concept that critical telomere shortening is related to aging and…”
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Localization and Regulation of the Growth Hormone Receptor and Growth Hormone‐Binding Protein in the Rat Growth Plate by Gevers, Evelien F., Van Der Eerden, Bram C. J., Karperien, Marcel, Raap, Anton K., Robinson, Iain C. A. F., Wit, Jan‐Maarten

“…Growth hormone (GH) has direct effects on the growth plate to stimulate longitudinal growth, but it is not clear which chondrocyte populations GH acts on. The…”
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In situ genotyping individual DNA molecules by target-primed rolling-circle amplification of padlock probes by Nilsson, Mats, Larsson, Chatarina, Koch, Jørn, Nygren, Anders, Janssen, George, Raap, Anton K, Landegren, Ulf

“…Methods are needed to study single molecules to reveal variability, interactions and mechanisms that may go undetected at the level of populations of…”
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Fluorochrome-labeled Tyramides: Use in Immunocytochemistry and Fluorescence In Situ Hybridization by van Gijlswijk, Rob P. M, Zijlmans, Henry J. M. A. A, Wiegant, Joop, Bobrow, Mark N, Erickson, Thomas J, Adler, Karl E, Tanke, Hans J, Raap, Anton K

“…The peroxidase-mediated deposition of hapten- and fluorochrome-labeled tyramides has recently been shown to increase the sensitivity of immunofluoresence and…”
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Mitochondrial diabetes: molecular mechanisms and clinical presentation by Maassen, J Antonie, 'T Hart, Leen M, Van Essen, Einar, Heine, Rob J, Nijpels, Giel, Jahangir Tafrechi, Roshan S, Raap, Anton K, Janssen, George M C, Lemkes, Herman H P J

“…Mutations in mitochondrial DNA (mtDNA) associate with various disease states. A few mtDNA mutations strongly associate with diabetes, with the most common…”
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Array comparative genomic hybridization with cyanin cis-platinum-labeled DNAs by Raap, Anton K, van der Burg, Marja J M, Knijnenburg, Jeroen, Meershoek, Eric, Rosenberg, Carla, Gray, Joe W, Wiegant, Joop, Hodgson, J Graeme, Tanke, Hans J

“…Fluorescent cis-platinum compounds that react with the N7 atom of guanine are useful for labeling nucleic acids influorescence hybridization applications. Here…”
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Molecular cytogenetic characterization by combined COBRA-FISH and fiber-FISH: application to PER.C6 cells by Wiegant, Joop, Brouwer, Kirsten, Bezrookove, Vladimir, Smits, Shirley, Raap, Anton K, Bout, Abraham, Tanke, Hans J

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Sensitive mRNA Detection by Fluorescence In Situ Hybridization Using Horseradish Peroxidase-labeled Oligodeoxynucleotides and Tyramide Signal Amplification by van de Corput, Mariette P.C, Dirks, Roeland W, van Gijlswijk, Rob P.M, van Binnendijk, Erica, Hattinger, Claudia M, de Paus, Roelof A, Landegent, Jim E, Raap, Anton K

“…With the ongoing progress in human genome projects, many genes are discovered whose function and/or expression pattern are not known. Most of these genes are…”
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Real‐time monitoring of rolling‐circle amplification using a modified molecular beacon design by Nilsson, Mats, Gullberg, Mats, Dahl, Fredrik, Szuhai, Karoly, Raap, Anton K.

“…We describe a method to monitor rolling‐circle replication of circular oligonucleotides in dual‐color and in real‐time using molecular beacons. The method can…”
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DNA Fiber-FISH Staining Mechanism by van de Rijke, Frans M, Florijn, Ralph J, Tanke, Hans J, Raap, Anton K

“…Fluorescence in situ hybridization to DNA fibers (Fiber-FISH) is a high-resolution, wide-ranging physical DNA mapping method that finds increasing application…”
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Quantitative assessment of a novel flow-through porous microarray for the rapid analysis of gene expression profiles by Wu, Ying, de Kievit, Peggy, Vahlkamp, Lars, Pijnenburg, Dirk, Smit, Maarten, Dankers, Martijn, Melchers, Diana, Stax, Martijn, Boender, Piet J., Ingham, Colin, Bastiaensen, Niek, de Wijn, Rik, van Alewijk, Dirk, van Damme, Henk, Raap, Anton K., Chan, Alan B., van Beuningen, Rinie

“…A novel microarray system that utilizes a porous aluminum-oxide substrate and flow-through incubation has been developed for rapid molecular biological…”
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Connexin 26 mutations in cases of sensorineural deafness in eastern Austria by Frei, Klemens, Szuhai, Károly, Lucas, Trevor, Weipoltshammer, Klara, Schöfer, Christian, Ramsebner, Reinhard, Baumgartner, Wolf-Dieter, Raap, Anton K, Bittner, Reginald, Wachtler, Franz J, Kirschhofer, Karin

“…Mutations in the connexin 26 (Cx26) gene (GJB2) are associated with autosomal nonsyndromic sensorineural hearing loss. This study describes mutations in the…”
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Simultaneous A8344G heteroplasmy and mitochondrial DNA copy number quantification in myoclonus epilepsy and ragged-red fibers (MERRF) syndrome by a multiplex molecular beacon based real-time fluorescence PCR by Szuhai, K, Ouweland, J, Dirks, R, Lemaître, M, Truffert, J, Janssen, G, Tanke, H, Holme, E, Maassen, J, Raap, A

“…The association of a particular mitochondrial DNA (mtDNA) mutation with different clinical phenotypes is a well-known feature of mitochondrial diseases. A…”
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A multiplexed and miniaturized serological tuberculosis assay identifies antigens that discriminate maximally between TB and non-TB sera by Tong, Miao, Jacobi, Catharina E., van de Rijke, Frans M., Kuijper, Sjoukje, van de Werken, Sjaak, Lowary, Todd L., Hokke, Cornelis H., Appelmelk, Ben J., Nagelkerke, Nico J.D., Tanke, Hans J., van Gijlswijk, Rob P.M., Veuskens, Jacques, Kolk, Arend H.J., Raap, Anton K.

“…We have developed a multiplexed and miniaturized TB serological assay with the aim of identifying (combinations of) antigens that maximally discriminate…”
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New insights in the molecular pathogenesis of the maternally inherited diabetes and deafness syndrome by Maassen, Johannes A, Jahangir Tafrechi, Roshan S, Janssen, George M C, Raap, Anton K, Lemkes, Herman H, 't Hart, Leen M

“…The 3243A>G mutation in mitochondrial DNA (mtDNA) is a genetic variant that is associated with a high risk of developing diabetes during life. Enhanced aging…”
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Single-cell A3243G Mitochondrial DNA Mutation Load Assays for Segregation Analysis by Jahangir Tafrechi, Roshan S, van de Rijke, Frans M, Allallou, Amin, Larsson, Chatarina, Sloos, Willem C.R, van de Sande, Marchien, Wahlby, Carolina, Janssen, George M.C, Raap, Anton K

“…Segregation of mitochondrial DNA (mtDNA) is an important underlying pathogenic factor in mtDNA mutation accumulation in mitochondrial diseases and aging, but…”
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