Search Results - "Raaijmakers, Hans C.A"

The X-ray Structure of RU486 Bound to the Progesterone Receptor in a Destabilized Agonistic Conformation by Raaijmakers, Hans C.A., Versteegh, Judith E., Uitdehaag, Joost C.M.

“…Here we describe the 1.95 Å structure of the clinically used antiprogestin RU486 (mifepristone) in complex with the progesterone receptor (PR). The structure…”
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Structural Basis for Agonism and Antagonism for a Set of Chemically Related Progesterone Receptor Modulators by Lusher, Scott J., Raaijmakers, Hans C.A., Vu-Pham, Diep, Dechering, Koen, Lam, Tsang Wai, Brown, Angus R., Hamilton, Niall M., Nimz, Olaf, Bosch, Rolien, McGuire, Ross, Oubrie, Arthur, de Vlieg, Jacob

“…The progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full…”
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Characterization of Irreversible Kinase Inhibitors by Directly Detecting Covalent Bond Formation: A Tool for Dissecting Kinase Drug Resistance by Klüter, Sabine, Simard, Jeffrey R, Rode, Haridas B, Grütter, Christian, Pawar, Vijaykumar, Raaijmakers, Hans C.A, Barf, Tjeerd A, Rabiller, Matthias, van Otterlo, Willem A.L, Rauh, Daniel

“…Targeting protein kinases in cancer therapy with irreversible small-molecule inhibitors is moving to the forefront of kinase-inhibitor research and is thought…”
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Structures of complement component C3 provide insights into the function and evolution of immunity by JANSSEN, Bert J. C, HUIZINGA, Eric G, RAAIJMAKERS, Hans C. A, ROOS, Anja, DAHA, Mohamed R, NILSSON-EKDAHL, Kristina, NILSSON, Bo, GROS, Piet

“…The mammalian complement system is a phylogenetically ancient cascade system that has a major role in innate and adaptive immunity. Activation of component C3…”
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Formate-reduced E. coli formate dehydrogenase H: The reinterpretation of the crystal structure suggests a new reaction mechanism by Raaijmakers, Hans C A, Romão, Maria João

“…Re-evaluation of the crystallographic data of the molybdenum-containing E. coli formate dehydrogenase H (Boyington et al. Science 275:1305-1308, 1997),…”
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X-ray Structures of Progesterone Receptor Ligand Binding Domain in Its Agonist State Reveal Differing Mechanisms for Mixed Profiles of 11β-Substituted Steroids by Lusher, Scott J., Raaijmakers, Hans C.A., Vu-Pham, Diep, Kazemier, Bert, Bosch, Rolien, McGuire, Ross, Azevedo, Rita, Hamersma, Hans, Dechering, Koen, Oubrie, Arthur, van Duin, Marcel, de Vlieg, Jacob

“…We present here the x-ray structures of the progesterone receptor (PR) in complex with two mixed profile PR modulators whose functional activity results from…”
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Structure of Complement Component C2a: Implications for Convertase Formation and Substrate Binding by Milder, Fin J., Raaijmakers, Hans C.A., Vandeputte, Mitja D.A.A., Schouten, Arie, Huizinga, Eric G., Romijn, Roland A., Hemrika, Wieger, Roos, Anja, Daha, Mohamed R., Gros, Piet

“…C2a provides the catalytic center to the convertase complexes of the classical and lectin-binding pathways of complement activation. We determined two crystal…”
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