Search Results - "Raaijmakers, Antonia J. A."

A Proteomics Approach to Identify New Putative Cardiac Intercalated Disk Proteins by Soni, Siddarth, Raaijmakers, Antonia J A, Raaijmakers, Linsey M, Damen, J Mirjam A, van Stuijvenberg, Leonie, Vos, Marc A, Heck, Albert J R, van Veen, Toon A B, Scholten, Arjen

“…Synchronous beating of the heart is dependent on the efficient functioning of the cardiac intercalated disk (ID). The ID is composed of a complex protein…”
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A gene therapy targeting medium-chain acyl-CoA dehydrogenase (MCAD) did not protect against diabetes-induced cardiac pathology by Weeks, Kate L., Kiriazis, Helen, Wadley, Glenn D., Masterman, Emma I., Sergienko, Nicola M., Raaijmakers, Antonia J. A., Trewin, Adam J., Harmawan, Claudia A., Yildiz, Gunes S., Liu, Yingying, Drew, Brian G., Gregorevic, Paul, Delbridge, Lea M. D., McMullen, Julie R., Bernardo, Bianca C.

“…Diabetic cardiomyopathy describes heart disease in patients with diabetes who have no other cardiac conditions but have a higher risk of developing heart…”
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Localized cardiomyocyte lipid accumulation is associated with slowed epicardial conduction in rats by Wells, Simon P, Raaijmakers, Antonia J A, Curl, Claire L, O'Shea, Christopher, Hayes, Sarah, Mellor, Kimberley M, Kalman, Jonathan M, Kirchhof, Paulus, Pavlovic, Davor, Delbridge, Lea M D, Bell, James R

“…Transmural action potential duration differences and transmural conduction gradients aid the synchronization of left ventricular repolarization, reducing…”
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Changes in Cx43 and NaV1.5 expression precede the occurrence of substantial fibrosis in calcineurin-induced murine cardiac hypertrophy by Fontes, Magda S C, Raaijmakers, Antonia J A, van Doorn, Tessa, Kok, Bart, Nieuwenhuis, Sylvia, van der Nagel, Roel, Vos, Marc A, de Boer, Teun P, van Rijen, Harold V M, Bierhuizen, Marti F A

“…In mice, the calcium-dependent phosphatase calcineurin A (CnA) induces a transcriptional pathway leading to pathological cardiac hypertrophy. Interestingly,…”
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Cardiomyocyte Functional Etiology in Heart Failure With Preserved Ejection Fraction Is Distinctive—A New Preclinical Model by Curl, Claire L., Danes, Vennetia R., Bell, James R., Raaijmakers, Antonia J. A., Ip, Wendy T. K., Chandramouli, Chanchal, Harding, Tristan W., Porrello, Enzo R., Erickson, Jeffrey R., Charchar, Fadi J., Kompa, Andrew R., Edgley, Amanda J., Crossman, David J., Soeller, Christian, Mellor, Kimberley M., Kalman, Jonathan M., Harrap, Stephen B., Delbridge, Lea M. D.

“…Background Among the growing numbers of patients with heart failure, up to one half have heart failure with preserved ejection fraction (HFpEF). The lack of…”
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Myocardial and Cardiomyocyte Stress Resilience Is Enhanced in Aromatase-Deficient Female Mouse Hearts Through CaMKIIδ Activation by Bell, James R, Bernasochi, Gabriel B, Wollermann, Amanda C, Raaijmakers, Antonia J. A, Boon, Wah Chin, Simpson, Evan R, Curl, Claire L, Mellor, Kimberley M, Delbridge, Lea M. D

“…The role of sex steroids in cardioprotection is contentious, with large clinical trials investigating hormone supplementation failing to deliver outcomes…”
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Epicardial Adipose Tissue Accumulation Confers Atrial Conduction Abnormality by Nalliah, Chrishan J, Bell, James R, Raaijmakers, Antonia J A, Waddell, Helen M, Wells, Simon P, Bernasochi, Gabriel B, Montgomery, Magdalene K, Binny, Simon, Watts, Troy, Joshi, Subodh B, Lui, Elaine, Sim, Choon Boon, Larobina, Marco, O'Keefe, Michael, Goldblatt, John, Royse, Alistair, Lee, Geoffrey, Porrello, Enzo R, Watt, Matthew J, Kistler, Peter M, Sanders, Prashanthan, Delbridge, Lea M D, Kalman, Jonathan M

“…Clinical studies have reported that epicardial adipose tissue (EpAT) accumulation associates with the progression of atrial fibrillation (AF) pathology and…”
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The cardiomyocyte origins of diastolic dysfunction: cellular components of myocardial "stiffness" by Janssens, Johannes V, Raaijmakers, Antonia J A, Weeks, Kate L, Bell, James R, Mellor, Kimberley M, Curl, Claire L, Delbridge, Lea M D

“…The impaired ability of the heart to relax and stretch to accommodate venous return is generally understood to represent a state of "diastolic dysfunction" and…”
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Sex and sex hormones in cardiac stress—Mechanistic insights by Bell, James R., Bernasochi, Gabriel B., Varma, Upasna, Raaijmakers, Antonia J.A., Delbridge, Lea M.D.

“…•Important sex differences are evident in cardiac stress responses.•Cardiac androgen/estrogen receptor activation modulates basal contractile function.•Sex…”
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Diastolic dysfunction is more apparent in STZ-induced diabetic female mice, despite less pronounced hyperglycemia by Chandramouli, Chanchal, Reichelt, Melissa E., Curl, Claire L., Varma, Upasna, Bienvenu, Laura A., Koutsifeli, Parisa, Raaijmakers, Antonia J. A., De Blasio, Miles J., Qin, Cheng Xue, Jenkins, Alicia J., Ritchie, Rebecca H., Mellor, Kimberley M., Delbridge, Lea M. D.

“…Diabetic cardiomyopathy is a distinct pathology characterized by early emergence of diastolic dysfunction. Increased cardiovascular risk associated with…”
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Systematic quantification of histologic ventricular fibrosis in isolated mitral valve prolapse and sudden cardiac death by Han, Hui-Chen, Parsons, Sarah A., Curl, Claire L., Teh, Andrew W., Raaijmakers, Antonia J.A., Koshy, Anoop N., Leong, Trishe, Burrell, Louise M., O’Donnell, David, Vohra, Jitendra K., Kalman, Jonathan M., Sanders, Prashanthan, Hare, David L., Farouque, Omar, Delbridge, Lea M.D., Lim, Han S.

“…Cardiac fibrosis in mitral valve prolapse (MVP) is implicated in the development of sudden cardiac death (SCD); however, the pattern remains poorly…”
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Altered cardiac structure and function is related to seizure frequency in a rat model of chronic acquired temporal lobe epilepsy by Powell, Kim L., Liu, Zining, Curl, Claire L., Raaijmakers, Antonia J.A., Sharma, Pragati, Braine, Emma L., Gomes, Flavia M., Sivathamboo, Shobi, Macefield, Vaughan G., Casillas-Espinosa, Pablo M., Jones, Nigel C., Delbridge, Lea M., O’Brien, Terence J.

“…This study aimed to prospectively examine cardiac structure and function in the kainic acid-induced post-status epilepticus (post-KA SE) model of chronic…”
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Calmodulin/CaMKII inhibition improves intercellular communication and impulse propagation in the heart and is antiarrhythmic under conditions when fibrosis is absent by Takanari, Hiroki, Bourgonje, Vincent J A, Fontes, Magda S C, Raaijmakers, Antonia J A, Driessen, Helen, Jansen, John A, van der Nagel, Roel, Kok, Bart, van Stuijvenberg, Leonie, Boulaksil, Mohamed, Takemoto, Yoshio, Yamazaki, Masatoshi, Tsuji, Yukiomi, Honjo, Haruo, Kamiya, Kaichiro, Kodama, Itsuo, Anderson, Mark E, van der Heyden, Marcel A G, van Rijen, Harold V M, van Veen, Toon A B, Vos, Marc A

“…In healthy hearts, ventricular gap junctions are mainly composed by connexin43 (Cx43) and localize in the intercalated disc, enabling appropriate electrical…”
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Sex-specific regulation of the cardiac transcriptome by the protein phosphatase 2A regulatory subunit B55α by Sergienko, Nicola M., Trewin, Adam J., Kiriazis, Helen, Raaijmakers, Antonia J. A., Donner, Daniel G., Garside, Victoria C., Smith, Kelly A., Bell, James R., Mellor, Kimberley M., Delbridge, Lea M. D., McMullen, Julie R., Weeks, Kate L.

“…Protein phosphatase 2A (PP2A) regulatory subunit B55α has been implicated in the transcriptional regulation of cardiac growth and fibrosis by suppressing…”
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Dietary omega-6 fatty acid replacement selectively impairs cardiac functional recovery after ischemia in female (but not male) rats by Ip, Wendy T K, McAlindon, Andrew, Miller, Sarah E, Bell, James R, Curl, Claire L, Huggins, Catherine E, Mellor, Kimberley M, Raaijmakers, Antonia J A, Bienvenu, Laura A, McLennan, Peter L, Pepe, Salvatore, Delbridge, Lea M D

“…A definitive understanding of the role of dietary lipids in determining cardioprotection (or cardiodetriment) has been elusive. Randomized trial findings have…”
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Cardiac CaMKIIδ splice variants exhibit target signaling specificity and confer sex-selective arrhythmogenic actions in the ischemic-reperfused heart by Bell, James R, Raaijmakers, Antonia J.A, Curl, Claire L, Reichelt, Melissa E, Harding, Tristan W, Bei, Aier, Ng, Dominic C.H, Erickson, Jeffrey R, Vila Petroff, Martin, Harrap, Stephen B, Delbridge, Lea M.D

“…Abstract Background Ischemia-related arrhythmic incidence is generally lower in females (vs males), though risk is selectively increased in women with…”
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CaMKIIδ and cardiomyocyte Ca2+ signalling new perspectives on splice variant targeting by Bell, James R, Raaijmakers, Antonia JA, Janssens, Johannes V, Delbridge, Lea MD

“…Summary Control of cardiomyocyte cytosolic Ca2+ levels is crucial in determining inotropic status and ischemia/reperfusion stress response. Responsive to…”
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CaMKIIδ and cardiomyocyte Ca(2+) signalling new perspectives on splice variant targeting by Bell, James R, Raaijmakers, Antonia J A, Janssens, Johannes V, Delbridge, Lea M D

“…Control of cardiomyocyte cytosolic Ca(2+) levels is crucial in determining inotropic status and ischemia/reperfusion stress response. Responsive to…”
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Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency by Crombie, Duncan E, Curl, Claire L, Raaijmakers, Antonia Ja, Sivakumaran, Priyadharshini, Kulkarni, Tejal, Wong, Raymond Cb, Minami, Itsunari, Evans-Galea, Marguerite V, Lim, Shiang Y, Delbridge, Lea, Corben, Louise A, Dottori, Mirella, Nakatsuji, Norio, Trounce, Ian A, Hewitt, Alex W, Delatycki, Martin B, Pera, Martin F, Pébay, Alice

“…We sought to identify the impacts of Friedreich's ataxia (FRDA) on cardiomyocytes. FRDA is an autosomal recessive degenerative condition with neuronal and…”
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Changes in Cx43 and Na.sub.V1.5 Expression Precede the Occurrence of Substantial Fibrosis in Calcineurin-Induced Murine Cardiac Hypertrophy by Fontes, Magda S. C, Raaijmakers, Antonia J. A, van Doorn, Tessa, Kok, Bart, Nieuwenhuis, Sylvia, van der Nagel, Roel, Vos, Marc A, de Boer, Teun P, van Rijen, Harold V. M, Bierhuizen, Marti F. A

“…In mice, the calcium-dependent phosphatase calcineurin A (CnA) induces a transcriptional pathway leading to pathological cardiac hypertrophy. Interestingly,…”
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