Search Results - "Raad, Houssam"

NADPH oxidase activation in neutrophils: Role of the phosphorylation of its subunits by Belambri, Sahra A., Rolas, Loïc, Raad, Houssam, Hurtado‐Nedelec, Margarita, Dang, Pham My‐Chan, El‐Benna, Jamel

“…Neutrophils are key cells of innate immunity and during inflammation. Upon activation, they produce large amounts of superoxide anion (O2−.) and ensuing…”
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NADPH Oxidase-1 Plays a Key Role in Keratinocyte Responses to UV Radiation and UVB-Induced Skin Carcinogenesis by Raad, Houssam, Serrano-Sanchez, Martin, Harfouche, Ghida, Mahfouf, Walid, Bortolotto, Doriane, Bergeron, Vanessa, Kasraian, Zeinab, Dousset, Lea, Hosseini, Mohsen, Taieb, Alain, Rezvani, Hamid Reza

“…The nicotinamide adenine dinucleotide phosphate oxidase (NOX) family enzymes are involved in several physiological functions. However, their roles in…”
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The protein kinase A negatively regulates reactive oxygen species production by phosphorylating gp91phox/NOX2 in human neutrophils by Raad, Houssam, Mouawia, Hussein, Hassan, Hamad, El-Seblani, Mohamed, Arabi-Derkawi, Riad, Boussetta, Tarek, Gougerot-Pocidalo, Marie-Anne, Dang, Pham My-Chan, El-Benna, Jamel

“…Superoxide anion production by neutrophils is essential for host defense against microbes. Superoxide anion generates other reactive oxygen species (ROS) that…”
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Effects of a Single Dose of Ivermectin on Viral and Clinical Outcomes in Asymptomatic SARS-CoV-2 Infected Subjects: A Pilot Clinical Trial in Lebanon by Samaha, Ali A, Mouawia, Hussein, Fawaz, Mirna, Hassan, Hamad, Salami, Ali, Bazzal, Ali Al, Saab, Hamid Bou, Al-Wakeel, Mohamed, Alsaabi, Ahmad, Chouman, Mohamad, Moussawi, Mahmoud Al, Ayoub, Hassan, Raad, Ali, Hajjeh, Ola, Eid, Ali H, Raad, Houssam

“…This study was designed to determine the efficacy of ivermectin, an FDA-approved drug, in producing clinical benefits and decreasing the viral load of…”
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Mice Deficient in Dual Oxidase Maturation Factors Are Severely Hypothyroid by Grasberger, Helmut, De Deken, Xavier, Mayo, Olga Barca, Raad, Houssam, Weiss, Mia, Liao, Xiao-Hui, Refetoff, Samuel

“…Dual oxidases (DUOX1 and DUOX2) are evolutionary conserved reduced nicotinamide adenine dinucleotide phosphate oxidases responsible for regulated hydrogen…”
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Retraction: Samaha et al. Effects of a Single Dose of Ivermectin on Viral and Clinical Outcomes in Asymptomatic SARS-CoV-2 Infected Subjects: A Pilot Clinical Trial in Lebanon. Viruses 2021, 13 , 989 by Samaha, Ali A, Mouawia, Hussein, Fawaz, Mirna, Hassan, Hamad, Salami, Ali, Bazzal, Ali Al, Saab, Hamid Bou, Al-Wakeel, Mohamed, Alsaabi, Ahmad, Chouman, Mohamad, Moussawi, Mahmoud Al, Ayoub, Hassan, Raad, Ali, Hajjeh, Ola, Eid, Ali H, Raad, Houssam

“…The journal retracts the article, Effects of a Single Dose of Ivermectin on Viral and Clinical Outcomes in Asymptomatic SARS-CoV-2 Infected Subjects: A Pilot…”
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Correction: Inhibition of p38 MAPK Signaling Augments Skin Tumorigenesis via NOX2 Driven ROS Generation by Liu, Liang, Rezvani, Hamid Reza, Back, Jung Ho, Hosseini, Mohsen, Tang, Xiuwei, Zhu, Yucui, Mahfouf, Walid, Raad, Houssam, Ragi, Grace, Athar, Mohammad, Kim, Arianna L, Bickers, David R

“…[This corrects the article DOI: 10.1371/journal.pone.0097245.]…”
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Characterization of NADPH Oxidase Expression and Activity in Acute Myeloid Leukemia Cell Lines: A Correlation with the Differentiation Status by Dakik, Hassan, El Dor, Maya, Leclerc, Joan, Kouzi, Farah, Nehme, Ali, Deynoux, Margaux, Debeissat, Christelle, Khamis, Georges, Ducrocq, Elfi, Ibrik, Aida, Stasia, Marie-José, Raad, Houssam, Rezvani, Hamid Reza, Gouilleux, Fabrice, Zibara, Kazem, Herault, Olivier, Mazurier, Frédéric

“…In acute myeloid leukemia (AML), a low level of reactive oxygen species (ROS) is associated with leukemic stem cell (LSC) quiescence, whereas a high level…”
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Inhibition of p38 MAPK signaling augments skin tumorigenesis via NOX2 driven ROS generation by Liu, Liang, Rezvani, Hamid Reza, Back, Jung Ho, Hosseini, Mohsen, Tang, Xiuwei, Zhu, Yucui, Mahfouf, Walid, Raad, Houssam, Ragi, Grace, Athar, Mohammad, Kim, Arianna L, Bickers, David R

“…p38 mitogen-activated protein kinases (MAPKs) respond to a wide range of extracellular stimuli. While the inhibition of p38 signaling is implicated in the…”
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Regulation of the phagocyte NADPH oxidase activity: phosphorylation of gp91phox/NOX2 by protein kinase C enhances its diaphorase activity and binding to Rac2, p67phox, and p47phox by Raad, Houssam, Paclet, Marie-Hélène, Boussetta, Tarek, Kroviarski, Yolande, Morel, Françoise, Quinn, Mark T, Gougerot-Pocidalo, Marie-Anne, Dang, Pham My-Chan, El-Benna, Jamel

“…Neutrophils generate microbicidal oxidants through activation of a multicomponent enzyme called NADPH oxidase. During activation, the cytosolic NADPH oxidase…”
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NADPH Oxidases and Their Roles in Skin Homeostasis and Carcinogenesis by Rudolf, Jana, Raad, Houssam, Taieb, Alain, Rezvani, Hamid Reza

“…Skin protects the body from dehydration, pathogens, and external mutagens. NADPH oxidases are central components for regulating the cellular redox balance…”
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The peptidyl-prolyl isomerase Pin1 controls GM-CSF-induced priming of NADPH oxidase in human neutrophils and priming at inflammatory sites by Boussetta, Tarek, Raad, Houssam, Bedouhene, Samia, Arabi Derkawi, Riad, Gougerot-Pocidalo, Marie-Anne, Hayem, Gilles, Dang, Pham My-Chan, El-Benna, Jamel

“…•GM-CSF induced the activation of the prolyl cis/trans isomerase Pin1 in human neutrophils.•Juglone and PiB, two Pin1 inhibitors dampens GM-CSF-induced priming…”
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Punicic acid a conjugated linolenic acid inhibits TNFalpha-induced neutrophil hyperactivation and protects from experimental colon inflammation in rats by Boussetta, Tarek, Raad, Houssam, Lettéron, Philippe, Gougerot-Pocidalo, Marie-Anne, Marie, Jean-Claude, Driss, Fathi, El-Benna, Jamel

“…Neutrophils play a major role in inflammation by releasing large amounts of ROS produced by NADPH-oxidase and myeloperoxidase (MPO). The proinflammatory…”
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The protein kinase A negatively regulates reactive oxygen species production by phosphorylating gp91phox/NOX2 in human neutrophils by Raad, Houssam, Mouawia, Hussein, Hassan, Hamad, El-Seblani, Mohamed, Arabi-Derkawi, Riad, Boussetta, Tarek, Gougerot-Pocidalo, Marie-Anne, Dang, Pham My-Chan, El-Benna, Jamel

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Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2 and its maturation factor DUOXA2 by Raad, Houssam, Eskalli, Zineb, Corvilain, Bernard, Miot, Françoise, De Deken, Xavier

“…The dual oxidases (DUOX) 1 and 2 constitute the major components of the thyroid H(2)O(2)-generating system required for thyroid hormone synthesis. With their…”
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Premature Skin Aging Features Rescued by Inhibition of NADPH Oxidase Activity in XPC-Deficient Mice by Hosseini, Mohsen, Mahfouf, Walid, Serrano-Sanchez, Martin, Raad, Houssam, Harfouche, Ghida, Bonneu, Marc, Claverol, Stephane, Mazurier, Frederic, Rossignol, Rodrigue, Taieb, Alain, Rezvani, Hamid Reza

“…Xeroderma pigmentosum type C (XP-C) is characterized mostly by a predisposition to skin cancers and accelerated photoaging, but little is known about premature…”
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Thyroid hydrogen peroxide production is enhanced by the Th2 cytokines, IL-4 and IL-13, through increased expression of the dual oxidase 2and its maturation factorDUOXA2 by Raad, Houssam, Eskalli, Zineb, Corvilain, Bernard, Miot, Françoise, De Deken, Xavier

“…The dual oxidases (DUOX) 1and 2constitute the major components of the thyroid H2O2-generating system required for thyroid hormone synthesis. With their…”
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Punicic Acid a Conjugated Linolenic Acid Inhibits TNFα-Induced Neutrophil Hyperactivation and Protects from Experimental Colon Inflammation in Rats by Boussetta, Tarek, Raad, Houssam, Lettéron, Philippe, Gougerot-Pocidalo, Marie-Anne, Marie, Jean-Claude, Driss, Fathi, El-Benna, Jamel

“…Background Neutrophils play a major role in inflammation by releasing large amounts of ROS produced by NADPH-oxidase and myeloperoxidase (MPO). The…”
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The Kinesin Light Chain–Related Protein PAT1 Promotes Superoxide Anion Production in Human Phagocytes by Arabi-Derkawi, Riad, O’dowd, Yvonne, Cheng, Ni, Rolas, Loïc, Boussetta, Tarek, Raad, Houssam, Marzaioli, Viviana, Pintard, Coralie, Fasseu, Magali, Kroviarski, Yolande, Belambri, Sahra A, Dang, Pham My-Chan, Ye, Richard D, Gougerot-Pocidalo, Marie-Anne, El-Benna, Jamel

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The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-α–induced priming of the NADPH oxidase in human neutrophils by Boussetta, Tarek, Gougerot-Pocidalo, Marie-Anne, Hayem, Gilles, Ciappelloni, Silvia, Raad, Houssam, Arabi Derkawi, Riad, Bournier, Odile, Kroviarski, Yolande, Zhou, Xiao Zhen, Malter, James S., Lu, Ping K., Bartegi, Aghleb, Dang, Pham My-Chan, El-Benna, Jamel

“…Neutrophils play a key role in host defense by releasing reactive oxygen species (ROS). However, excessive ROS production by neutrophil nicotinamide adenine…”
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