Search Results - "Raabe, Hans A."
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Human relevance of in vivo and in vitro skin irritation tests for hazard classification of pesticides
Published in Cutaneous and ocular toxicology (24-08-2024)“…Test methods to inform hazard characterization and labeling of pesticides to protect human health are typically conducted using laboratory animals, and for…”
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Human-relevant approaches to assess eye corrosion/irritation potential of agrochemical formulations
Published in Cutaneous and ocular toxicology (03-04-2021)“…There are multiple in vitro and ex vivo eye irritation and corrosion test methods that are available as internationally harmonized test guidelines for…”
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Defined approaches to classify agrochemical formulations into EPA hazard categories developed using EpiOcular TM reconstructed human corneal epithelium and bovine corneal opacity and permeability assays
Published in Cutaneous and ocular toxicology (01-03-2024)“…Many sectors have seen complete replacement of the rabbit eye test with reproducible and relevant and methods to assess the eye corrosion/irritation potential…”
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Vaginal irritation models: the current status of available alternative and in vitro tests
Published in Alternatives to laboratory animals (01-09-2011)“…Mucosal surfaces, such as the vaginal epithelium, are natural barriers to infection that are constantly exposed to bacteria and viruses, and are therefore…”
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In Vitro Assessment of Skin Irritation Potential of Surfactant-based Formulations by Using a 3-D Skin Reconstructed Tissue Model and Cytokine Response
Published in Alternatives to laboratory animals (01-12-2016)“…The personal care industry is focused on developing safe, more efficacious, and increasingly milder products, that are routinely undergoing preclinical and…”
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Implementation of New Test Methods into Practical Testing
Published in Advances in experimental medicine and biology (01-01-2016)“…New toxicology test methods, especially those using in vitro methods, are continually being developed. Some are used by industry for screening purposes; others…”
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Defined approaches to classify agrochemical formulations into EPA hazard categories developed using EpiOcularTM reconstructed human corneal epithelium and bovine corneal opacity and permeability assays
Published in Cutaneous and ocular toxicology (01-03-2024)“…Many sectors have seen complete replacement of the in vivo rabbit eye test with reproducible and relevant in vitro and ex vivo methods to assess the eye…”
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Local Tolerance Testing under REACH: Accepted Non-animal Methods are Not on Equal Footing with Animal Tests
Published in Alternatives to laboratory animals (01-07-2016)“…In general, no single non-animal method can cover the complexity of any given animal test. Therefore, fixed sets of in vitro (and in chemico) methods have been…”
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Using the cytosensor microphysiometer to assess ocular toxicity
Published in Current protocols in toxicology (07-08-2014)“…Measuring in vitro cytotoxicity is one method currently used to estimate damage to the eye after chemical exposure. The Cytosensor Microphysiometer method…”
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