Search Results - "Ra Lee, So"

Targeting the Notch and TGF-β signaling pathways to prevent retinal fibrosis in vitro and in vivo by Fan, Jiawen, Shen, Weiyong, Lee, So-Ra, Mathai, Ashish Easow, Zhang, Rui, Xu, Gezhi, Gillies, Mark C

“…The Notch and transforming growth factor-β (TGFβ) signaling pathways are two intracellular mechanisms that control fibrosis in general but whether they play a…”
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Effect of selectively knocking down key metabolic genes in Müller glia on photoreceptor health by Shen, Weiyong, Lee, So‐Ra, Mathai, Ashish Easow, Zhang, Rui, Du, Jianhai, Yam, Michelle X., Pye, Victoria, Barnett, Nigel L., Rayner, Cassie L., Zhu, Ling, Hurley, James B., Seth, Pankaj, Hirabayashi, Yoshio, Furuya, Shigeki, Gillies, Mark C.

“…The importance of Müller glia for retinal homeostasis suggests that they may have vulnerabilities that lead to retinal disease. Here, we studied the effect of…”
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Preclinical and clinical studies of photobiomodulation therapy for macular oedema by Shen, Weiyong, Teo, Kelvin Yi Chong, Wood, John P. M., Vaze, Anagha, Chidlow, Glyn, Ao, Jack, Lee, So-Ra, Yam, Michelle X., Cornish, Elisa E., Fraser-Bell, Samantha, Casson, Robert J., Gillies, Mark C.

“…Aims/hypothesis Diabetic macular oedema (DME) is the leading cause of visual impairment in people with diabetes. Intravitreal injections of vascular…”
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Hard Tissue Volume Stability Effect beyond the Bony Envelope of a Three-Dimensional Preformed Titanium Mesh with Two Different Collagen Barrier Membranes on Peri-Implant Dehiscence Defects in the Anterior Maxilla: A Randomized Clinical Trial by Lee, So-Ra, Jang, Tae-Sik, Seo, Chang-Su, Choi, In-Oh, Lee, Won-Pyo

“…This single-blinded, randomized, controlled study aimed to clinically and radiographically evaluate hard tissue volume stability beyond the bony envelope using…”
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Matrix metalloproteinase-9 of tubular and macrophage origin contributes to the pathogenesis of renal fibrosis via macrophage recruitment through osteopontin cleavage by Kui Tan, Thian, Zheng, Guoping, Hsu, Tzu-Ting, Ra Lee, So, Zhang, Jianlin, Zhao, Ye, Tian, Xinrui, Wang, Yiping, Min Wang, Yuan, Cao, Qi, Wang, Ya, Lee, Vincent WS, Wang, Changqi, Zheng, Dong, Alexander, Stephen I, Thompson, Erik, Harris, David C H

“…A pro-fibrotic role of matrix metalloproteinase-9 (MMP-9) in tubular cell epithelial–mesenchymal transition (EMT) is well established in renal fibrosis;…”
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Profiling of microRNAs involved in retinal degeneration caused by selective Müller cell ablation by Chung, Sook Hyun, Gillies, Mark, Sugiyama, Yuki, Zhu, Ling, Lee, So-Ra, Shen, Weiyong

“…Dysfunction of Müller cells has been implicated in the pathogenesis of several retinal diseases. In order to understand the potential contribution of Müller…”
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Cardioprotective effects of PKG activation by soluble GC activator, BAY 60-2770, in ischemia-reperfusion-injured rat hearts by Lee, Kyung Hye, Lee, So-Ra, Cho, Haneul, Woo, Jong Shin, Kang, Jung Hee, Jeong, Yun-Mi, Cheng, Xian Wu, Kim, Woo-Shik, Kim, Weon

“…Soluble guanylate cyclase (sGC) has been suggested as a therapeutic target for cardiac ischemia-reperfusion (IR) injury. Until now, the molecular mechanism of…”
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3‐O‐acetylrubianol C (3AR‐C) induces RIPK1‐dependent programmed cell death by selective inhibition of IKKβ by Kang, Kidong, Quan, Khong Trong, Byun, Hee Sun, Lee, So‐Ra, Piao, Xuezhe, Ju, Eunjin, Park, Kyeong Ah, Sohn, Kyung‐Cheol, Shen, Han‐Ming, Na, MinKyun, Hur, Gang Min

“…In tumor necrosis factor (TNF) signaling, phosphorylation and activation of receptor interacting protein kinase 1 (RIPK1) by upstream kinases is an essential…”
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Effect of glucocorticoids on neuronal and vascular pathology in a transgenic model of selective Müller cell ablation by Shen, Weiyong, Lee, So-Ra, Araujo, Joana, Chung, Sook H., Zhu, Ling, Gillies, Mark C.

“…Retinal diseases such as macular telangiectasis type 2 (MacTel), age‐related macular degeneration (AMD) and diabetic retinopathy (DR) affect both neurons and…”
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Inhibiting the activation of MAPK (ERK1/2) in stressed Müller cells prevents photoreceptor degeneration by Zeng, Shaoxue, Zhang, Ting, Chen, Yingying, Chu-Tan, Joshua, Jin, Kaiyu, Lee, So-Ra, Yam, Michelle X, Madigan, Michele C., Fernando, Nilisha, Cioanca, Adrian, Zhou, Fanfan, Zhu, Meidong, Zhang, Junjun, Natoli, Riccardo, Fan, Xiaohui, Zhu, Ling, Gillies, Mark C

“…Rationale: Müller cells play an essential role in maintaining the health of retinal photoreceptors. Dysfunction of stressed Müller cells often results in…”
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Optogenetic restoration of high sensitivity vision with bReaChES, a red-shifted channelrhodopsin by Too, Lay Khoon, Shen, Weiyong, Protti, Dario A., Sawatari, Atomu, A. Black, Dylan, Leamey, Catherine A., Y. Huang, Jin, Lee, So-Ra, E. Mathai, Ashish, Lisowski, Leszek, Y. Lin, John, C. Gillies, Mark, Simunovic, Matthew P.

“…The common final pathway to blindness in many forms of retinal degeneration is the death of the light-sensitive primary retinal neurons. However, the normally…”
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Transketolase in human Müller cells is critical to resist light stress through the pentose phosphate and NRF2 pathways by Chen, Yingying, Zhang, Ting, Zeng, Shaoxue, Xu, Rong, Jin, Kaiyu, Coorey, Nathan J., Wang, Yekai, Wang, Ke, Lee, So-Ra, Yam, Michelle, Zhu, Meidong, Chang, Andrew, Fan, Xiaohui, Zhang, Meixia, Du, Jianhai, Gillies, Mark C., Zhu, Ling

“…The Pentose Phosphate Pathway (PPP), a metabolic offshoot of the glycolytic pathway, provides protective metabolites and molecules essential for cell redox…”
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Systemic administration of erythropoietin inhibits retinopathy in RCS rats by Shen, Weiyong, Chung, Sook H, Irhimeh, Mohammad R, Li, Shiying, Lee, So-Ra, Gillies, Mark C

“…Royal College of Surgeons (RCS) rats develop vasculopathy as photoreceptors degenerate. The aim of this study was to examine the effect of erythropoietin (EPO)…”
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Accelerated degradation of cFLIPL and sensitization of the TRAIL DISC-mediated apoptotic cascade by pinoresinol, a lignan isolated from Rubia philippinensis by Lee, So-Ra, Quan, Khong Trong, Byun, Hee Sun, Park, InWha, Kang, Kidong, Piao, Xuezhe, Ju, Eunjin, Ro, Hyunju, Na, MinKyun, Hur, Gang Min

“…Plant-derived lignans have numerous biological effects including anti-tumor and anti-inflammatory activities. Screening of purified constituents of Rubia…”
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Novel Genetic Associations for Skin Aging Phenotypes and Validation of Previously Reported Skin GWAS Results by Cha, Mi-Yeon, Choi, Ja-Eun, Lee, Da-Som, Lee, So-Ra, Lee, Sang-In, Park, Jong-Ho, Shin, Jin-Hee, Suh, In Soo, Kim, Byung Ho, Hong, Kyung-Won

“…Facial skin characteristics are complex traits determined by genetic and environmental factors. Because genetic factors continuously influenced facial skin…”
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Effects of Ranibizumab and Aflibercept on Human Müller Cells and Photoreceptors under Stress Conditions by Shen, Weiyong, Yau, Belinda, Lee, So-Ra, Zhu, Ling, Yam, Michelle, Gillies, Mark C

“…Anti-vascular endothelial growth factor (VEGF) therapy has revolutionized the treatment of retinal vascular diseases. However, constitutive VEGF also acts as a…”
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Comparison of Lettuce Growth under Continuous and Pulsed Irradiation Using Light-Emitting Diodes by Son, Ki-Ho, Lee, So-Ra, Oh, Myung-Min

“…We determined the effects of various frequencies of pulsed light-emitting diode (LED) irradiation on the growth characteristics of Lactuca sativa L. ‘Sunmang’…”
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Effects of sildenafil on nanostructural and nanomechanical changes in mitochondria in an ischaemia-reperfusion rat model by Lee, Kyung Hye, Kwon, Sung Jin, Woo, Jong-Shin, Lee, Gi-Ja, Lee, So-Ra, Jang, Hyun-Hee, Kim, Hyun Soo, Kim, Jung Wook, Park, Hun Kuk, Cho, Kyu Seok, Kim, Weon

“…Summary Sildenafil exerts cardioprotective effects by activating the opening of mitochondrial ATP‐sensitive potassium channels to attenuate…”
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Exenatide Prevents Morphological and Structural Changes of Mitochondria Following Ischaemia-Reperfusion Injury by Lee, Kyung Hye, PhD, Ha, Sang Jin, MA, PhD, Woo, Jong-Shin, MD, Lee, Gi-Ja, PhD, Lee, So-Ra, MS, Kim, Jung Wook, MD, Park, Hun Kuk, MD, PhD, Kim, Weon, MD, PhD

“…Background Exenatide exerts cardioprotective effects by attenuating ischaemic reperfusion injury, possibly through activating the opening of mitochondrial…”
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Ferric-chelate reductase activity is a limiting factor in iron uptake in spinach and kale roots by Lee, So-Ra, Oh, Myung-Min, Park, Sin-Ae

“…Iron (Fe) is essential for many vital processes in plants, including chlorophyll biosynthesis, DNA synthesis, nitrogen reduction, and photosynthetic electron…”
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