Search Results - "Rämisch, Sebastian"

Explaining Operational Instability of Amine Transaminases: Substrate-Induced Inactivation Mechanism and Influence of Quaternary Structure on Enzyme–Cofactor Intermediate Stability by Börner, Tim, Rämisch, Sebastian, Reddem, Eswar R, Bartsch, Sebastian, Vogel, Andreas, Thunnissen, Andy-Mark W. H, Adlercreutz, Patrick, Grey, Carl

“…The insufficient operational stability of amine transaminases (ATA) constitutes a limiting factor for high productivity in chiral amine synthesis. In this…”
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DnaK response to expression of protein mutants is dependent on translation rate and stability by Christensen, Signe, Rämisch, Sebastian, André, Ingemar

“…Chaperones play a central part in the quality control system in cells by clearing misfolded and aggregated proteins. The chaperone DnaK acts as a sensor for…”
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Automatically Fixing Errors in Glycoprotein Structures with Rosetta by Frenz, Brandon, Rämisch, Sebastian, Borst, Andrew J., Walls, Alexandra C., Adolf-Bryfogle, Jared, Schief, William R., Veesler, David, DiMaio, Frank

“…Recent advances in single-particle cryo-electron microscopy (cryoEM) have resulted in determination of an increasing number of protein structures with resolved…”
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Computational design of a leucine-rich repeat protein with a predefined geometry by Rämisch, Sebastian, Weininger, Ulrich, Martinsson, Jonas, Akke, Mikael, André, Ingemar

“…Structure-based protein design offers a possibility of optimizing the overall shape of engineered binding scaffolds to match their targets better. We developed…”
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Three in One: Temperature, Solvent and Catalytic Stability by Engineering the Cofactor‐Binding Element of Amine Transaminase by Börner, Tim, Rämisch, Sebastian, Bartsch, Sebastian, Vogel, Andreas, Adlercreutz, Patrick, Grey, Carl

“…Amine transaminase (ATA) catalyse enantioselectively the direct amination of ketones, but insufficient stability during catalysis limits their industrial…”
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Molecular definition of multiple sites of antibody inhibition of malaria transmission-blocking vaccine antigen Pfs25 by Scally, Stephen W., McLeod, Brandon, Bosch, Alexandre, Miura, Kazutoyo, Liang, Qi, Carroll, Sean, Reponen, Sini, Nguyen, Ngan, Giladi, Eldar, Rämisch, Sebastian, Yusibov, Vidadi, Bradley, Allan, Lemiale, Franck, Schief, William R., Emerling, Daniel, Kellam, Paul, King, C. Richter, Julien, Jean-Philippe

“…The Plasmodium falciparum Pfs25 protein (Pfs25) is a leading malaria transmission-blocking vaccine antigen. Pfs25 vaccination is intended to elicit antibodies…”
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Potent antibody lineage against malaria transmission elicited by human vaccination with Pfs25 by McLeod, Brandon, Miura, Kazutoyo, Scally, Stephen W., Bosch, Alexandre, Nguyen, Ngan, Shin, Hanjun, Kim, Dongkyoon, Volkmuth, Wayne, Rämisch, Sebastian, Chichester, Jessica A., Streatfield, Stephen, Woods, Colleen, Schief, William R., Emerling, Daniel, King, C. Richter, Julien, Jean-Philippe

“…Transmission-blocking vaccines have the potential to be key contributors to malaria elimination. Such vaccines elicit antibodies that inhibit parasites during…”
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Exploring alternate states and oligomerization preferences of coiled-coils by de novo structure modeling by Ramisch, Sebastian, Lizatovic, Robert, Andre, Ingemar

“…ABSTRACT Homomeric coiled‐coils can self‐assemble into a wide range of structural states with different helix topologies and oligomeric states. In this study,…”
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Glycoengineering HIV-1 Env creates 'supercharged' and 'hybrid' glycans to increase neutralizing antibody potency, breadth and saturation by Crooks, Ema T, Grimley, Samantha L, Cully, Michelle, Osawa, Keiko, Dekkers, Gillian, Saunders, Kevin, Rämisch, Sebastian, Menis, Sergey, Schief, William R, Doria-Rose, Nicole, Haynes, Barton, Murrell, Ben, Cale, Evan Mitchel, Pegu, Amarendra, Mascola, John R, Vidarsson, Gestur, Binley, James M

“…The extensive glycosylation of HIV-1 envelope (Env) glycoprotein leaves few glycan-free holes large enough to admit broadly neutralizing antibodies (bnAb)…”
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Automated de novo phasing and model building of coiled-coil proteins by Ramisch, Sebastian, Lizatovic, Robert, Andre, Ingemar

“…Models generated by de novo structure prediction can be very useful starting points for molecular replacement for systems where suitable structural homologues…”
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Back Cover: Three in One: Temperature, Solvent and Catalytic Stability by Engineering the Cofactor‐Binding Element of Amine Transaminase (ChemBioChem 15/2017) by Börner, Tim, Rämisch, Sebastian, Bartsch, Sebastian, Vogel, Andreas, Adlercreutz, Patrick, Grey, Carl

“…The back cover picture shows an engineered, highly stable amine transaminase that catalyses the enantioselective amination of ketones under process conditions,…”
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Crystal structure of human chondroadherin: solving a difficult molecular‐replacement problem using de novo models by Rämisch, Sebastian, Pramhed, Anna, Tillgren, Viveka, Aspberg, Anders, Logan, Derek T.

“…Chondroadherin (CHAD) is a cartilage matrix protein that mediates the adhesion of isolated chondrocytes. Its protein core is composed of 11 leucine‐rich…”
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Pathogen specific, IRF3-dependent signaling and innate resistance to human kidney infection by Fischer, Hans, Lutay, Nataliya, Ragnarsdóttir, Bryndís, Yadav, Manisha, Jönsson, Klas, Urbano, Alexander, Al Hadad, Ahmed, Rämisch, Sebastian, Storm, Petter, Dobrindt, Ulrich, Salvador, Ellaine, Karpman, Diana, Jodal, Ulf, Svanborg, Catharina

“…The mucosal immune system identifies and fights invading pathogens, while allowing non-pathogenic organisms to persist. Mechanisms of pathogen/non-pathogen…”
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Vom „erfolgreichen Durchdringen des nationalen Gedankens“ und dem „Sieg der demokratischen Grundsätze“. Deutungsmuster von Nation und Demokratie in Oberschlesien, dem Teschener Schlesien und der Orava (1918/19) by Ramisch-Paul, Sebastian, Wehowski, Matthäus

“…After the end of World War I, Eastern Europe entered a period of upheaval. The continental empires dissolved and new nation-states emerged. Following the ideas…”
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Computational Design of Repeat-Proteins with a Predefined Geometry by Rämisch, Sebastian, Weininger, Ulrich, Martnisson, Jonas, Akke, Mikael, André, Ingemar

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Biophysical and Structural Characterization of Antibody Responses to Malaria Antigens by Scally, Stephen, Bosch, Alexander, McLeod, Brandon, Triller, Gianna, Imkeller, Katharina, Murugan, Rajagopal, Rämisch, Sebastian, King, Rick, Schief, William, Wardemann, Hedda, Julien, Jean-Philippe

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Zeiten der Unsicherheiten. Demokratisierung und Nationalisierung in Ostmitteleuropa auf regionaler und lokaler Ebene (1918–1923) by Kailitz, Steffen, Ramisch-Paul, Sebastian, Buchen, Tim

“…Zeiten des Umbruchs sind Zeiten der Unsicherheit. Sie zeichnen sich wesentlich dadurch aus, dass alte Gewissheiten verloren gehen und – nach Reinhart Koselleck…”
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Structural delineation of human antibody responses against malaria transmission-blocking vaccine antigen Pfs25 by McLeod, Brandon, Miura, Kazutoyo, Scally, Stephen W., Bosch, Alexandre, Rämisch, Sebastian, Yusibov, Vidadi, Schief, William R., Emerling, Daniel, King, C. Richter, Julien, Jean-Philippe

“…Abstract only…”
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mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models by Wang, Xuesong, Cottrell, Christopher A, Hu, Xiaozhen, Ray, Rashmi, Bottermann, Maria, Villavicencio, Paula Maldonado, Yan, Yu, Xie, Zhenfei, Warner, John E, Ellis-Pugh, Jordan Renae, Kalyuzhniy, Oleksandr, Liguori, Alessia, Willis, Jordan R, Menis, Sergey, Rämisch, Sebastian, Eskandarzadeh, Saman, Kubitz, Michael, Tingle, Ryan, Phelps, Nicole, Groschel, Bettina, Himansu, Sunny, Carfi, Andrea, Kirsch, Kathrin H, Weldon, Stephanie R, Nair, Usha, Schief, William R, Batista, Facundo D

“…Germline-targeting (GT) protein immunogens to induce VRC01-class broadly neutralizing antibodies (bnAbs) to the CD4-binding site of the HIV envelope (Env) have…”
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Pathogen Specific, IRF3-Dependent Signaling and Innate Resistance to Human Kidney Infection: e1001109 by Fischer, Hans, Lutay, Nataliya, Ragnarsdóttir, Bryndís, Yadav, Manisha, Jönsson, Klas, Urbano, Alexander, Hadad, Ahmed Al, Rämisch, Sebastian, Storm, Petter, Dobrindt, Ulrich, Salvador, Ellaine, Karpman, Diana, Jodal, Ulf, Svanborg, Catharina

“…The mucosal immune system identifies and fights invading pathogens, while allowing non-pathogenic organisms to persist. Mechanisms of pathogen/non-pathogen…”
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