Search Results - "Raškevičius, Vytautas"

A metabolic modeling approach reveals promising therapeutic targets and antiviral drugs to combat COVID-19 by Santos-Beneit, Fernando, Raškevičius, Vytautas, Skeberdis, Vytenis A., Bordel, Sergio

“…In this study we have developed a method based on Flux Balance Analysis to identify human metabolic enzymes which can be targeted for therapeutic intervention…”
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Genome scale metabolic models as tools for drug design and personalized medicine by Raškevičius, Vytautas, Mikalayeva, Valeryia, Antanavičiūtė, Ieva, Ceslevičienė, Ieva, Skeberdis, Vytenis Arvydas, Kairys, Visvaldas, Bordel, Sergio

“…In this work we aim to show how Genome Scale Metabolic Models (GSMMs) can be used as tools for drug design. By comparing the chemical structures of human…”
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Phosphorylation-dependent allosteric regulation of Cx43 gap junction inhibitor potency by Mickus, Rokas, Raškevičius, Vytautas, Sarapinienė, Ieva, Mikalayeva, Valeryia, Prekeris, Rytis, Skeberdis, Vytenis Arvydas

“…Physiological and pathological processes such as homeostasis, embryogenesis, development, tumorigenesis, and cell movement depend on the intercellular…”
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Impact of CYP2C19 Gene Variants on Long-Term Treatment with Atorvastatin in Patients with Acute Coronary Syndromes by Čereškevičius, Darius, Zabiela, Vytautas, Aldujeli, Ali, Lesauskaitė, Vaiva, Zubielienė, Kristina, Raškevičius, Vytautas, Čiapienė, Ieva, Žaliaduonytė, Diana, Giedraitienė, Agnė, Žvikas, Vaidotas, Jakštas, Valdas, Skipskis, Vilius, Dobilienė, Olivija, Šakalytė, Gintarė, Tatarūnas, Vacis

“…The effectiveness of lipid-lowering therapies may be insufficient in high-risk cardiovascular patients and depends on the genetic variability of…”
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The effect of nutmeg essential oil constituents on Novikoff hepatoma cell viability and communication through Cx43 gap junctions by Mickus, Rokas, Jančiukė, Gintarė, Raškevičius, Vytautas, Mikalayeva, Valeryia, Matulytė, Inga, Marksa, Mindaugas, Maciūnas, Kęstutis, Bernatonienė, Jurga, Skeberdis, Vytenis Arvydas

“…[Display omitted] •Cellular effects of essential oils from plants lack mechanistic explanations and structure–activity relationship testing.•Nutmeg essential…”
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Evaluation of Cx43 Gap Junction Inhibitors Using a Quantitative Structure-Activity Relationship Model by Matusevičiūtė, Ramona, Ignatavičiūtė, Eglė, Mickus, Rokas, Bordel, Sergio, Skeberdis, Vytenis Arvydas, Raškevičius, Vytautas

“…Gap junctions (GJs) made of connexin-43 (Cx43) are necessary for the conduction of electrical impulses in the heart. Modulation of Cx43 GJ activity may be…”
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Molecular basis for potentiation of Cx36 gap junction channel conductance by n -alcohols and general anesthetics by Raškevičius, Vytautas, Jotautis, Vaidas, Rimkutė, Lina, Marandykina, Alina, Kazokaitė, Mintautė, Kairys, Visvaldas, Skeberdis, Vytenis Arvydas

“…In our recent study, we have demonstrated that short carbon chain -alcohols (up to octanol) stimulated while long carbon chain -alcohols inhibited the…”
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Predicting Isoform-specific Binding Selectivities of Benzensulfonamides Using QSAR and 3D-QSAR by Raskevicius, Vytautas, Kairys, Visvaldas

“…Design of isoform-specific inhibitors is a major challenge in the new therapeutic agents development. The article describes the development of a robust…”
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Comparison of Performance of Docking, LIE, Metadynamics and QSAR in Predicting Binding Affinity of Benzenesulfonamides by Raškevičius, Vytautas, Kairys, Visvaldas

“…The design of inhibitors specific for one relevant carbonic anhydrase isozyme is the major challenge in the new therapeutic agents development. Comparative…”
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Synthesis and antiproliferative activity of α-branched α,β-unsaturated ketones in human hematological and solid cancer cell lines by Karpavičienė, Ieva, Valiulienė, Giedrė, Raškevičius, Vytautas, Lebedytė, Indrė, Brukštus, Algirdas, Kairys, Visvaldas, Rūta Navakauskienė, Čikotienė, Inga

“…A series of α-branched α,β-unsaturated ketones were prepared via boron trifluoride etherate mediated reaction between arylalkynes and carboxaldehydes. The…”
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Impact of ICYP2C19/I Gene Variants on Long-Term Treatment with Atorvastatin in Patients with Acute Coronary Syndromes by Čereškevičius, Darius, Zabiela, Vytautas, Aldujeli, Ali, Lesauskaitė, Vaiva, Zubielienė, Kristina, Raškevičius, Vytautas, Čiapienė, Ieva, Žaliaduonytė, Diana, Giedraitienė, Agnė, Žvikas, Vaidotas, Jakštas, Valdas, Skipskis, Vilius, Dobilienė, Olivija, Šakalytė, Gintarė, Tatarūnas, Vacis

“…The effectiveness of lipid-lowering therapies may be insufficient in high-risk cardiovascular patients and depends on the genetic variability of…”
Get full text