Search Results - "Ra, Eun A."
-
1
Human cytomegalovirus-encoded US9 targets MAVS and STING signaling to evade type I interferon immune responses
Published in Nature communications (09-01-2018)“…Human cytomegalovirus (HCMV) has evolved sophisticated immune evasion mechanisms that target both the innate and adaptive immune responses. However, how HCMV…”
Get full text
Journal Article -
2
TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells
Published in Nature communications (24-05-2016)“…Autophagy is responsible for the bulk degradation of cytosolic constituents and plays an essential role in the intestinal epithelium by controlling beneficial…”
Get full text
Journal Article -
3
HCMV-encoded US7 and US8 act as antagonists of innate immunity by distinctively targeting TLR-signaling pathways
Published in Nature communications (11-10-2019)“…The mechanisms by which many human cytomegalovirus (HCMV)-encoded proteins help the virus to evade immune surveillance remain poorly understood. In particular,…”
Get full text
Journal Article -
4
The nucleolus is the site for inflammatory RNA decay during infection
Published in Nature communications (03-09-2022)“…Inflammatory cytokines are key signaling molecules that can promote an immune response, thus their RNA turnover must be tightly controlled during infection…”
Get full text
Journal Article -
5
Optogenetic induction of alpha-synuclein aggregation in human dopaminergic neurons to model Parkinson’s disease pathology
Published in STAR protocols (15-12-2023)“…Alpha-synuclein (α-syn) aggregation is a principal factor in Parkinson’s disease (PD) onset. Here, we present a protocol for optogenetic induction of α-syn…”
Get full text
Journal Article -
6
Negative self-regulation of TLR9 signaling by its N-terminal proteolytic cleavage product
Published in The Journal of immunology (1950) (01-10-2014)“…TLR signaling is essential to innate immunity against microbial invaders and must be tightly controlled. We have previously shown that TLR9 undergoes…”
Get full text
Journal Article -
7
Differential control of interleukin-6 mRNA levels by cellular distribution of YB-1
Published in PloS one (14-11-2014)“…Cytokine production is essential for innate and adaptive immunity against microbial invaders and must be tightly controlled. Cytokine messenger RNA (mRNA) is…”
Get full text
Journal Article -
8
Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation
Published in Cell stem cell (06-07-2023)“…Human induced pluripotent stem cells (hiPSCs) offer advantages for disease modeling and drug discovery. However, recreating innate cellular pathologies,…”
Get full text
Journal Article -
9
CNBP acts as a key transcriptional regulator of sustained expression of interleukin-6
Published in Nucleic acids research (07-04-2017)“…The transcription of inflammatory genes is an essential step in host defense activation. Here, we show that cellular nucleic acid-binding protein (CNBP) acts…”
Get full text
Journal Article -
10
STRAP Acts as a Scaffolding Protein in Controlling the TLR2/4 Signaling Pathway
Published in Scientific reports (09-12-2016)“…The WD40-repeat protein serine/threonine kinase receptor-associated protein (STRAP) is involved in the regulation of several biological processes, including…”
Get full text
Journal Article -
11
-
12
Impact of vitamin D receptor gene polymorphisms on clinical outcomes of HLA-matched sibling hematopoietic stem cell transplantation
Published in Clinical transplantation (01-05-2012)“…Cho HJ, Shin DY, Kim JH, Bae JY, Lee KH, See CJ, Kim N, Park EK, Ra EK, Lee JE, Hong YC, Kim HK, Park SS, Yoon SS, Lee DS, Han KS, Park MH, Park S, Kim BK, Kim…”
Get full text
Journal Article -
13
P2X7 receptor polymorphism and clinical outcomes in HLA-matched sibling allogeneic hematopoietic stem cell transplantation
Published in Haematologica (Roma) (01-05-2007)“…From the Department of Internal Medicine (K-HL, IK, S-SY, SP, BKK); Department of Laboratory Medicine (SSP, EKR); Department of Preventive Medicine, Seoul…”
Get full text
Journal Article -
14
Glutathione S-transferase A1 polymorphisms and acute graft-vs.-host disease in HLA-matched sibling allogeneic hematopoietic stem cell transplantation
Published in Clinical transplantation (01-03-2007)“…: Busulfan and the metabolites of cyclophosphamide are conjugated with glutathione and catabolized by enzymes of the cytosolic glutathione S‐transferases…”
Get full text
Journal Article -
15
버킷림프종에서 EZH2 분해제와 METTL3 억제제 병용의 상승 항암 효과
Published in Korean journal of clinical laboratory science (2024)“…EZH2 is a methyltransferase that is a critical target for lymphoma treatment. However, it is not yet widely used in clinical settings. PROteolysis TArgeting…”
Get full text
Journal Article -
16