Search Results - "RYU, Byoung Y"

Optimizing lentiviral vector transduction of hematopoietic stem cells for gene therapy by Jang, Yoonjeong, Kim, Yoon-Sang, Wielgosz, Matthew M., Ferrara, Francesca, Ma, Zhijun, Condori, Jose, Palmer, Lance E., Zhao, Xiwen, Kang, Guolian, Rawlings, David J., Zhou, Sheng, Ryu, Byoung Y.

“…Autologous gene therapy using lentiviral vectors (LVs) holds promise for treating monogenetic blood diseases. However, clinical applications can be limited by…”
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Genome editing of HBG1 and HBG2 to induce fetal hemoglobin by Métais, Jean-Yves, Doerfler, Phillip A., Mayuranathan, Thiyagaraj, Bauer, Daniel E., Fowler, Stephanie C., Hsieh, Matthew M., Katta, Varun, Keriwala, Sagar, Lazzarotto, Cicera R., Luk, Kevin, Neel, Michael D., Perry, S. Scott, Peters, Samuel T., Porter, Shaina N., Ryu, Byoung Y., Sharma, Akshay, Shea, Devlin, Tisdale, John F., Uchida, Naoya, Wolfe, Scot A., Woodard, Kaitly J., Wu, Yuxuan, Yao, Yu, Zeng, Jing, Pruett-Miller, Shondra, Tsai, Shengdar Q., Weiss, Mitchell J.

“…Induction of fetal hemoglobin (HbF) via clustered regularly interspaced short palindromic repeats/Cas9–mediated disruption of DNA regulatory elements that…”
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Preclinical proof of concept for VivoVec, a lentiviral-based platform for in vivo CAR T-cell engineering by Michels, Kathryn R, Sheih, Alyssa, Hernandez, Susana A, Brandes, Alissa H, Parrilla, Don, Irwin, Blythe, Perez, Anai M, Ting, Hung-An, Nicolai, Christopher J, Gervascio, Timothy, Shin, Seungjin, Pankau, Mark D, Muhonen, Mason, Freeman, Jessica, Gould, Sarah, Getto, Rich, Larson, Ryan P, Ryu, Byoung Y, Scharenberg, Andrew M, Sullivan, Alessandra M, Green, Shon

“…BackgroundChimeric antigen receptor (CAR) T-cell therapies have demonstrated transformational outcomes in the treatment of B-cell malignancies, but their…”
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Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI by Aubert, Martine, Ryu, Byoung Y, Banks, Lindsey, Rawlings, David J, Scharenberg, Andrew M, Jerome, Keith R

“…Current antiviral therapy does not cure HIV-infected individuals because the virus establishes lifelong latent infection within long-lived memory T cells as…”
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An experimental system for the evaluation of retroviral vector design to diminish the risk for proto-oncogene activation by Ryu, Byoung Y., Evans-Galea, Marguerite V., Gray, John T., Bodine, David M., Persons, Derek A., Nienhuis, Arthur W.

“…Pathogenic activation of the LMO2 proto-oncogene by an oncoretroviral vector insertion in a clinical trial for X-linked severe combined immunodeficiency…”
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Effective, safe, and sustained correction of murine XLA using a UCOE-BTK promoter-based lentiviral vector by Seymour, Brenda J., Singh, Swati, Certo, Hannah M., Sommer, Karen, Sather, Blythe D., Khim, Socheath, Clough, Courtnee, Hale, Malika, Pangallo, Joseph, Ryu, Byoung Y., Khan, Iram F., Adair, Jennifer E., Rawlings, David J.

“…X-linked agammaglobulinemia (XLA) is an immune disorder caused by mutations in Bruton’s tyrosine kinase (BTK). BTK is expressed in B and myeloid cells, and its…”
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Targeted Entry via Somatostatin Receptors Using a Novel Modified Retrovirus Glycoprotein That Delivers Genes at Levels Comparable to Those of Wild-Type Viral Glycoproteins by FANG LI, RYU, Byoung Y, KRUEGER, Robin L, HELDT, Scott A, ALBRITTON, Lorraine M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Daedalus: a robust, turnkey platform for rapid production of decigram quantities of active recombinant proteins in human cell lines using novel lentiviral vectors by Bandaranayake, Ashok D., Correnti, Colin, Ryu, Byoung Y., Brault, Michelle, Strong, Roland K., Rawlings, David J.

“…A key challenge for the academic and biopharmaceutical communities is the rapid and scalable production of recombinant proteins for supporting downstream…”
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In vivo CAR T-cell generation in nonhuman primates using lentiviral vectors displaying a multidomain fusion ligand by Nicolai, Christopher J., Parker, Maura H., Qin, Jim, Tang, Weiliang, Ulrich-Lewis, Justin T., Gottschalk, Rebecca J., Cooper, Sara E., Hernandez Lopez, Susana A., Parrilla, Don, Mangio, Richard S., Ericson, Nolan G., Brandes, Alissa H., Umuhoza, Saluwa, Michels, Kathryn R., McDonnell, Mollie M., Park, Lisa Y., Shin, Seungjin, Leung, Wai-Hang, Scharenberg, Andrew M., Kiem, Hans-Peter, Larson, Ryan P., Beitz, Laurie O., Ryu, Byoung Y.

“…•Lentiviral vectors displaying T-cell activation and costimulatory molecules (VivoVec) generate CAR T cells in vivo without lymphodepletion.•VivoVec…”
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Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes by Ozog, Stosh, Timberlake, Nina D., Hermann, Kip, Garijo, Olivia, Haworth, Kevin G., Shi, Guoli, Glinkerman, Christopher M., Schefter, Lauren E., D'Souza, Saritha, Simpson, Elizabeth, Sghia-Hughes, Gabriella, Carillo, Raymond R., Boger, Dale L., Kiem, Hans-Peter, Slukvin, Igor, Ryu, Byoung Y., Sorrentino, Brian P., Adair, Jennifer E., Snyder, Scott A., Compton, Alex A., Torbett, Bruce E.

“…Therapeutic gene delivery to hematopoietic stem cells (HSCs) holds great potential as a life-saving treatment of monogenic, oncologic, and infectious diseases…”
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Coupling endonucleases with DNA end–processing enzymes to drive gene disruption by Certo, Michael T, Gwiazda, Kamila S, Kuhar, Ryan, Sather, Blythe, Curinga, Gabrielle, Mandt, Tyler, Brault, Michelle, Lambert, Abigail R, Baxter, Sarah K, Jacoby, Kyle, Ryu, Byoung Y, Kiem, Hans-Peter, Gouble, Agnes, Paques, Frederic, Rawlings, David J, Scharenberg, Andrew M

“…Coexpression of DNA end–processing enzymes with targeted nucleases improves the efficiency of gene disruption in mammalian cells. Targeted DNA double-strand…”
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Ubiquitous high-level gene expression in hematopoietic lineages provides effective lentiviral gene therapy of murine Wiskott-Aldrich syndrome by Astrakhan, Alexander, Sather, Blythe D., Ryu, Byoung Y., Khim, Socheath, Singh, Swati, Humblet-Baron, Stephanie, Ochs, Hans D., Miao, Carol H., Rawlings, David J.

“…The immunodeficiency disorder Wiskott-Aldrich syndrome (WAS) leads to life-threatening hematopoietic cell dysfunction. We used WAS protein (WASp)–deficient…”
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Tracking genome engineering outcome at individual DNA breakpoints by Certo, Michael T, Ryu, Byoung Y, Annis, James E, Garibov, Mikhail, Jarjour, Jordan, Rawlings, David J, Scharenberg, Andrew M

“…A fluorescent reporter, named traffic light, reads out whether repair of a DNA break occurs by nonhomologous end-joining or by homologous recombination. It…”
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B cell–specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia by Kerns, Hannah M., Ryu, Byoung Y., Stirling, Brigid V., Sather, Blythe D., Astrakhan, Alexander, Humblet-Baron, Stephanie, Liggitt, Denny, Rawlings, David J.

“…The immunodeficiency disorder, X-linked agammaglobulinemia (XLA), results from mutations in the gene encoding Bruton tyrosine kinase (Btk). Btk is required for…”
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Developmentally regulated expression of MEF2C limits the response to BCR engagement in transitional B cells by Andrews, Sarah F., Dai, Xuezhi, Ryu, Byoung Y., Gulick, Tod, Ramachandran, Bindu, Rawlings, David J.

“…Transitional and naïve mature peripheral B cells respond very differently to B‐cell receptor (BCR) cross‐linking. While transitional B cells undergo apoptosis…”
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Development of B-lineage Predominant Lentiviral Vectors for Use in Genetic Therapies for B Cell Disorders by Sather, Blythe D, Ryu, Byoung Y, Stirling, Brigid V, Garibov, Mikhail, Kerns, Hannah M, Humblet-Baron, Stéphanie, Astrakhan, Alexander, Rawlings, David J

“…Sustained, targeted, high-level transgene expression in primary B lymphocytes may be useful for gene therapy in B cell disorders. We developed several…”
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Novel reporter systems for facile evaluation of I-SceI-mediated genome editing by Muñoz, Nina M., Beard, Brian C., Ryu, Byoung Y., Luche, Ralf M., Trobridge, Grant D., Rawlings, David J., Scharenberg, Andrew M., Kiem, Hans-Peter

“…Two major limitations to achieve efficient homing endonuclease-stimulated gene correction using retroviral vectors are low frequency of gene targeting and…”
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The block to membrane fusion differs with the site of ligand insertion in modified retroviral envelope proteins by Ryu, Byoung Y, Zavorotinskaya, Tatiana, Trentin, Bernadette, Albritton, Lorraine M

“…Department of Molecular Sciences, University of Tennessee Health Science Center, Memphis, TN, USA Correspondence Lorraine M. Albritton lalbritton{at}utmem.edu…”
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A chromatin insulator blocks interactions between globin regulatory elements and cellular promoters in erythroid cells by Ryu, Byoung Y., Persons, Derek A., Evans-Galea, Marguerite V., Gray, John T., Nienhuis, Arthur W.

“…Retroviral vectors have been developed for gene therapy of blood disorders because they achieve long-term expression of the transgene. However, interactions…”
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1059. The Influence of a Chromatin Insulator on Interactions between Globin Regulatory Elements and Cellular Promoters in Erythroid Cells by Ryu, Byoung Y., Persons, Derek A., Nienhuis, Arthur W.

“…Integrating retroviral vectors have been developed for gene therapy of blood disorders because they achieve long term expression of the transgene. However,…”
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