Search Results - "RYAN, Stephen J"

A protocol for the culture and differentiation of highly polarized human retinal pigment epithelial cells by Hinton, David R, Sonoda, Shozo, Spee, Christine, Barron, Ernesto, Ryan, Stephen J, Kannan, Ram

“…We provide our detailed, standardized in vitro protocol for the culture and differentiation of human retinal pigment epithelial (RPE) cells into a highly…”
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αB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells by Sreekumar, Parameswaran G, Kannan, Ram, Kitamura, Mizuki, Spee, Christine, Barron, Ernesto, Ryan, Stephen J, Hinton, David R

“…αB crystallin is a chaperone protein with anti-apoptotic and anti-inflammatory functions and has been identified as a biomarker in age-related macular…”
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BMP4 Mediates Oxidative Stress-induced Retinal Pigment Epithelial Cell Senescence and Is Overexpressed in Age-related Macular Degeneration by Zhu, DanHong, Wu, Jian, Spee, Christine, Ryan, Stephen J., Hinton, David R.

“…The retinal pigment epithelium is a primary site of pathology in age-related macular degeneration. Oxidative stress and senescence are both thought to be…”
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Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux by Sreekumar, Parameswaran G, Spee, Christine, Ryan, Stephen J, Cole, Susan P C, Kannan, Ram, Hinton, David R

“…Absence of α-crystallins (αA and αB) in retinal pigment epithelial (RPE) cells renders them susceptible to oxidant-induced cell death. We tested the hypothesis…”
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Over-expression of BMP4 inhibits experimental choroidal neovascularization by modulating VEGF and MMP-9 by Xu, Jing, Zhu, Danhong, Sonoda, Shozo, He, Shikun, Spee, Christine, Ryan, Stephen J., Hinton, David R.

“…Bone morphorgenetic protein (BMP)-4 has been shown to play a pivotal role in eye development; however, its role in mature retina or ocular angiogenic diseases…”
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Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: relevance to age-related macular degeneration by Sonoda, Shozo, Sreekumar, Parameswaran G, Kase, Satoru, Spee, Christine, Ryan, Stephen J, Kannan, Ram, Hinton, David R

“…The antiangiogenic and neurotrophic growth factor, pigment epithelial derived factor (PEDF), and the proangiogenic growth factor, vascular endothelial growth…”
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Connective Tissue Growth Factor as a Mediator of Intraocular Fibrosis by He, Shikun, Chen, Youxin, Khankan, Rima, Barron, Ernesto, Burton, Richard, Zhu, DanHong, Ryan, Stephen J, Oliver, Noelynn, Hinton, David R

“…To investigate the role of connective tissue growth factor (CTGF) in the pathogenesis of proliferative vitreoretinopathy (PVR). Expression of CTGF was…”
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Endoplasmic reticulum stress induced by oxidative stress in retinal pigment epithelial cells by He, Shikun, Yaung, Jennifer, Kim, Yeong Hoon, Barron, Ernesto, Ryan, Stephen J., Hinton, David R.

“…Background Induction of glucose-regulated protein (GRP)-78 in the endoplasmic reticulum (ER) is a protective mechanism cells use to adapt to ER stress. We…”
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MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranes by Hoffmann, Stephan, He, Shikun, Ehren, Marianne, Ryan, Stephen J, Wiedemann, Peter, Hinton, David R

“…Matrix metalloproteinases (MMP)-2 and -9 play an important role in the pathogenesis of choroidal neovascularization (CNV). Retinal pigment epithelial cells…”
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Differential expression of pro- and antiangiogenic factors in mouse strain-dependent hypoxia-induced retinal neovascularization by CHAN, Candy K, PHAM, Lucia N, JIEHAO ZHOU, SPEE, Christine, RYAN, Stephen J, HINTON, David R

“…Clinical observations suggest that genetic factors may influence heterogeneity of angiogenic responses in cardiovascular disease, proliferative diabetic…”
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Chronic inflammatory demyelinating polyneuropathy: considerations for diagnosis, management, and population health by Ryan, Melody, Ryan, Stephen J

“…First described almost 50 years ago, chronic inflammatory demyelinating polyneuropathy (CIDP) is a rare autoimmune disorder characterized by progressive…”
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Protection from oxidative stress by methionine sulfoxide reductases in RPE cells by Sreekumar, Parameswaran G., Kannan, Ram, Yaung, Jennifer, Spee, Christine K., Ryan, Stephen J., Hinton, David R.

“…We investigated the role of methionine sulfoxide reductases (Msrs) in oxidant-stress-induced cell death in retinal pigmented epithelial (RPE) cells. In RPE…”
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Regulation of thioredoxin by ceramide in retinal pigment epithelial cells by Sreekumar, Parameswaran G., Ding, Yi, Ryan, Stephen J., Kannan, Ram, Hinton, David R.

“…The purpose of this study was to determine the expression, regulation and signaling of a key redoxin family member thioredoxin 1 (Trx1) in normal,…”
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Thiol regulation of vascular endothelial growth factor-A and its receptors in human retinal pigment epithelial cells by Sreekumar, Parameswaran G., Kannan, Ram, de Silva, Aruni T., Burton, Richard, Ryan, Stephen J., Hinton, David R.

“…We investigated the secretion and expression of VEGF-A and its receptors in human retinal pigment epithelial cells (RPE) under conditions of oxidative stress…”
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αB-crystallin regulation of angiogenesis by modulation of VEGF by Kase, Satoru, He, Shikun, Sonoda, Shozo, Kitamura, Mizuki, Spee, Christine, Wawrousek, Eric, Ryan, Stephen J., Kannan, Ram, Hinton, David R.

“…αB-crystallin is a chaperone belonging to the small heat shock protein family. Herein we show attenuation of intraocular angiogenesis in αB-crystallin knockout…”
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Deficiency of αB crystallin augments ER stress-induced apoptosis by enhancing mitochondrial dysfunction by Dou, Guorui, Sreekumar, Parameswaran G., Spee, Christine, He, Shikun, Ryan, Stephen J., Kannan, Ram, Hinton, David R.

“…Endoplasmic reticulum (ER) stress is linked to several pathological conditions including age-related macular degeneration. Excessive ER stress initiates cell…”
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Cerebral monitoring during carotid endarterectomy using near-infrared diffuse optical spectroscopies and electroencephalogram by Shang, Yu, Cheng, Ran, Dong, Lixin, Ryan, Stephen J, Saha, Sibu P, Yu, Guoqiang

“…Intraoperative monitoring of cerebral hemodynamics during carotid endarterectomy (CEA) provides essential information for detecting cerebral hypoperfusion…”
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Characterization of Brimonidine Transport in Retinal Pigment Epithelium by Zhang, Ning, Kannan, Ram, Okamoto, Curtis T, Ryan, Stephen J, Lee, Vincent H. L, Hinton, David R

“…To investigate the involvement of carrier-mediated transport mechanisms in brimonidine transport in retinal pigment epithelium (RPE). The transport of…”
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Governmental, university, pharmaceutical, and foundation partnerships to advance translational research in retinal disease by Ryan, Stephen J

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Soluble EphB4 Regulates Choroidal Endothelial Cell Function and Inhibits Laser-Induced Choroidal Neovascularization by He, Shikun, Ding, Yi, Zhou, Jiehao, Krasnoperov, Valery, Zozulya, Sergey, Kumar, S. Ram, Ryan, Stephen J, Gill, Parkash S, Hinton, David R

“…The purpose of this study was to evaluate the effect of a soluble monomeric form of the EphB4 extracellular domain (sEphB4) on choroidal endothelial cell (CEC)…”
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