Search Results - "RYAN, Karen K"

Neuroendocrine Circuits Governing Energy Balance and Stress Regulation: Functional Overlap and Therapeutic Implications by Ulrich-Lai, Yvonne M., Ryan, Karen K.

“…Significant comorbidities between obesity-related metabolic disease and stress-related psychological disorders suggest important functional interactions…”
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FXR is a molecular target for the effects of vertical sleeve gastrectomy by Ryan, Karen K., Tremaroli, Valentina, Clemmensen, Christoffer, Kovatcheva-Datchary, Petia, Myronovych, Andriy, Karns, Rebekah, Wilson-Pérez, Hilary E., Sandoval, Darleen A., Kohli, Rohit, Bäckhed, Fredrik, Seeley, Randy J.

“…Bariatric surgical procedures, such as vertical sleeve gastrectomy (VSG), are at present the most effective therapy for the treatment of obesity, and are…”
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Vertical Sleeve Gastrectomy Is Effective in Two Genetic Mouse Models of Glucagon-Like Peptide 1 Receptor Deficiency by WILSON-PÉREZ, Hilary E, CHAMBERS, Adam P, RYAN, Karen K, BAILING LI, SANDOVAL, Darleen A, STOFFERS, Doris, DRUCKER, Daniel J, PÉREZ-TILVE, Diego, SEELEY, Randy J

“…Glucagon-like peptide 1 (GLP-1) is a peptide hormone that is released from the gut in response to nutrient ingestion and that has a range of metabolic effects,…”
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Central Nervous System Mechanisms Linking the Consumption of Palatable High-Fat Diets to the Defense of Greater Adiposity by Ryan, Karen K., Woods, Stephen C., Seeley, Randy J.

“…The central nervous system (CNS) plays key role in the homeostatic regulation of body weight. Satiation and adiposity signals, providing acute and chronic…”
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Fibroblast Growth Factor-21 Controls Dietary Protein Intake in Male Mice by Larson, Karlton R, Chaffin, Aki T-B, Goodson, Michael L, Fang, Yanbin, Ryan, Karen K

“…Whereas carbohydrates and lipids are stored as glycogen and fat, there is no analogous inert storage form of protein. Therefore, continuous adjustments in…”
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Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight‐loss‐independent manner by Myronovych, Andriy, Kirby, Michelle, Ryan, Karen K., Zhang, Wujuan, Jha, Pinky, Setchell, Kenneth DR, Dexheimer, Phillip J., Aronow, Bruce, Seeley, Randy J., Kohli, Rohit

“…Objective Our objective was to investigate the role of bile acids in hepatic steatosis reduction after vertical sleeve gastrectomy (VSG). Design and Methods…”
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Fibroblast Growth Factor-19 Action in the Brain Reduces Food Intake and Body Weight and Improves Glucose Tolerance in Male Rats by Ryan, Karen K, Kohli, Rohit, Gutierrez-Aguilar, Ruth, Gaitonde, Shrawan G, Woods, Stephen C, Seeley, Randy J

“…Fibroblast growth factor-19 (FGF19) and its rodent ortholog, FGF15, are hormones produced in the distal small intestine and secreted into the circulation after…”
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Sex Differences in the Hormonal and Metabolic Response to Dietary Protein Dilution by Larson, Karlton R, Russo, Kimberly A, Fang, Yanbin, Mohajerani, Niloufar, Goodson, Michael L, Ryan, Karen K

“…Consumption of a low-protein, high-carbohydrate diet induces a striking increase in circulating fibroblast growth factor-21 (FGF21), which is associated with…”
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Food as a Hormone by Ryan, Karen K., Seeley, Randy J.

“…Nutrient substrates derived from food can activate intracellular signaling cascades to regulate metabolic health. Diet has an enormous impact on many aspects…”
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A Surgical Model in Male Obese Rats Uncovers Protective Effects of Bile Acids Post-Bariatric Surgery by Kohli, Rohit, Setchell, Kenneth DR, Kirby, Michelle, Myronovych, Andriy, Ryan, Karen K, Ibrahim, Samar H, Berger, Jose, Smith, Kathi, Toure, Mouhamadoul, Woods, Stephen C, Seeley, Randy J

“…Bariatric surgery elevates serum bile acids. Conjugated bile acid administration, such as tauroursodeoxycholic acid (TUDCA), improves insulin sensitivity,…”
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Perinatal Exposure to Bisphenol-A and the Development of Metabolic Syndrome in CD-1 Mice by Ryan, Karen K, Haller, April M, Sorrell, Joyce E, Woods, Stephen C, Jandacek, Ronald J, Seeley, Randy J

“…Bisphenol-A (BPA) is an endocrine-disrupting chemical used in the production of plastic food and beverage containers, leading to ubiquitous low-dose human…”
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Oral l-Arginine Stimulates GLP-1 Secretion to Improve Glucose Tolerance in Male Mice by Clemmensen, Christoffer, Smajilovic, Sanela, Smith, Eric P, Woods, Stephen C, Bräuner-Osborne, Hans, Seeley, Randy J, D'Alessio, David A, Ryan, Karen K

“…Pharmacological and surgical interventions that increase glucagon-like peptide 1 (GLP-1) action are effective to improve glucose homeostasis in type 2 diabetes…”
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Effect of vertical sleeve gastrectomy on food selection and satiation in rats by Chambers, Adam P, Wilson-Perez, Hilary E, McGrath, Sean, Grayson, Bernadette E, Ryan, Karen K, D'Alessio, David A, Woods, Stephen C, Sandoval, Darleen A, Seeley, Randy J

“…Vertical sleeve gastrectomy (VSG) is a restrictive procedure that reduces food intake to produce weight loss. Here we assess volume and nutrient effects on the…”
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FGF21 controls hepatic lipid metabolism via sex-dependent interorgan crosstalk by Chaffin, Aki T., Larson, Karlton R., Huang, Kuei-Pin, Wu, Chih-Ting, Godoroja, Nadejda, Fang, Yanbin, Jayakrishnan, Devi, Soto Sauza, Karla A., Sims, Landon C., Mohajerani, Niloufar, Goodson, Michael L., Ryan, Karen K.

“…The liver regulates energy partitioning and use in a sex-dependent manner, coupling hepatic substrate availability to female reproductive status. Fibroblast…”
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Bile Acid Signaling: Mechanism for Bariatric Surgery, Cure for NASH? by Kohli, Rohit, Myronovych, Andriy, Tan, Brandon K, Salazar-Gonzalez, Rosa-Maria, Miles, Lili, Zhang, Wujuan, Oehrle, Melissa, Sandoval, Darleen A, Ryan, Karen K, Seeley, Randy J, Setchell, Kenneth D R

“…Bariatric surgery is the most effective and durable treatment option for obesity today. More importantly, beyond weight loss, bariatric procedures have many…”
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FGF21 mediating the Sex-dependent Response to Dietary Macronutrients by Soto Sauza, Karla A, Ryan, Karen K

“…Abstract Sex is key variable influencing body composition and substrate utilization. At rest, females maintain greater adiposity than males and resist the…”
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Context matters for addressing controversies in FGF21 biology by Wu, Chih-Ting, Ryan, Karen K.

“…Recent discoveries by Solon-Biet and colleagues highlight the importance of nutritional context for addressing current controversies in Fibroblast Growth…”
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Dietary protein restriction diminishes sucrose reward and reduces sucrose-evoked mesolimbic dopamine signaling in mice by Wu, Chih-Ting, Gonzalez Magaña, Diego, Roshgadol, Jacob, Tian, Lin, Ryan, Karen K.

“…A growing literature suggests manipulating dietary protein status decreases sweet consumption in rodents and in humans. Underlying neurocircuit mechanisms have…”
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Adipose Mitochondrial Complex I Deficiency Modulates Inflammation and Glucose Homeostasis in a Sex-Dependent Manner by Choi, Kyung-Mi, Ryan, Karen K, Yoon, John C

“…Mitochondrial dysfunction in adipose tissue has been associated with type 2 diabetes, but it is unclear whether it is a cause or the consequence. Mitochondrial…”
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Dietary protein restriction modulates ‘dessert’ intake after a meal, via fibroblast growth factor 21 (FGF21) by Wu, Chih-Ting, Larson, Karlton R., Sims, Landon C., Ryan, Karen K.

“…•Mice maintained on a low-protein diet did not decrease sweet ‘dessert’ intake following a pre-load meal.•Mice, especially males, maintained on a low-protein…”
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