Search Results - "RUZZENE, Maria"

Role of protein kinase CK2 in antitumor drug resistance by Borgo, Christian, Ruzzene, Maria

“…Drug resistance represents the major reason of pharmacological treatment failure. It is supported by a broad spectrum of mechanisms, whose molecular bases have…”
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Protein kinase CK2: a potential therapeutic target for diverse human diseases by Borgo, Christian, D’Amore, Claudio, Sarno, Stefania, Salvi, Mauro, Ruzzene, Maria

“…CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of substrates, controls several signaling pathways, and is implicated in a…”
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Addiction to protein kinase CK2: A common denominator of diverse cancer cells? by Ruzzene, Maria, Pinna, Lorenzo A.

“…At variance with most oncogenic protein kinases whose malignancy is generally due to genetic alterations conferring constitutive activity, CK2 is a highly…”
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Casein kinase: the triple meaning of a misnomer by Venerando, Andrea, Ruzzene, Maria, Pinna, Lorenzo A

“…The term 'casein kinase' has been widely used for decades to denote protein kinases sharing the ability to readily phosphorylate casein in vitro. These fall…”
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The selectivity of inhibitors of protein kinase CK2: an update by Pagano, Mario A, Bain, Jenny, Kazimierczuk, Zygmunt, Sarno, Stefania, Ruzzene, Maria, Di Maira, Giovanni, Elliott, Matthew, Orzeszko, Andrzej, Cozza, Giorgio, Meggio, Flavio, Pinna, Lorenzo A

“…CK2 (casein kinase 2) is a very pleiotropic serine/threonine protein kinase whose abnormally high constitutive activity has often been correlated to…”
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Targeting CK2 in cancer: a valuable strategy or a waste of time? by Salvi, Mauro, Borgo, Christian, Pinna, Lorenzo A., Ruzzene, Maria

“…CK2 is a protein kinase involved in several human diseases (ranging from neurological and cardiovascular diseases to autoimmune disorders, diabetes, and…”
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A novel class of selective CK2 inhibitors targeting its open hinge conformation by Dalle Vedove, Andrea, Zonta, Francesca, Zanforlin, Enrico, Demitri, Nicola, Ribaudo, Giovanni, Cazzanelli, Giulia, Ongaro, Alberto, Sarno, Stefania, Zagotto, Giuseppe, Battistutta, Roberto, Ruzzene, Maria, Lolli, Graziano

“…Protein kinase CK2 sustains cancer growth, especially in hematological malignancies. Its inhibitor SRPIN803, based on a…”
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Effects of CK2β subunit down-regulation on Akt signalling in HK-2 renal cells by Alcaraz, Estefania, Vilardell, Jordi, Borgo, Christian, Sarró, Eduard, Plana, Maria, Marin, Oriano, Pinna, Lorenzo A, Bayascas, José R, Meseguer, Anna, Salvi, Mauro, Itarte, Emilio, Ruzzene, Maria

“…The PI3K/Akt pathway is interconnected to protein kinase CK2, which directly phosphorylates Akt1 at S129. We have previously found that, in HK-2 renal cells,…”
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Helicobacter pylori periplasmic receptor CeuE (HP1561) modulates its nickel affinity via organic metallophores by Shaik, Md Munan, Cendron, Laura, Salamina, Marco, Ruzzene, Maria, Zanotti, Giuseppe

“…Summary In Gram‐negative bacteria, nickel uptake is guaranteed by multiple and complex systems that operate at the membrane and periplasmic level. Helicobacter…”
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Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2 by Cozza, Giorgio, Mazzorana, Marco, Papinutto, Elena, Bain, Jenny, Elliott, Matthew, di Maira, Giovanni, Gianoncelli, Alessandra, Pagano, Mario A, Sarno, Stefania, Ruzzene, Maria, Battistutta, Roberto, Meggio, Flavio, Moro, Stefano, Zagotto, Giuseppe, Pinna, Lorenzo A

“…Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) is a moderately potent and poorly selective inhibitor of protein kinase CK2, one of the most pleiotropic…”
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A V1143F mutation in the neuronal-enriched isoform 2 of the PMCA pump is linked with ataxia by Vicario, Mattia, Zanni, Ginevra, Vallese, Francesca, Santorelli, Filippo, Grinzato, Alessandro, Cieri, Domenico, Berto, Paola, Frizzarin, Martina, Lopreiato, Raffaele, Zonta, Francesco, Ferro, Stefania, Sandre, Michele, Marin, Oriano, Ruzzene, Maria, Bertini, Enrico, Zanotti, Giuseppe, Brini, Marisa, Calì, Tito, Carafoli, Ernesto

“…The fine regulation of intracellular calcium is fundamental for all eukaryotic cells. In neurons, Ca2+ oscillations govern the synaptic development, the…”
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Design, validation and efficacy of bisubstrate inhibitors specifically affecting ecto-CK2 kinase activity by Cozza, Giorgio, Zanin, Sofia, Sarno, Stefania, Costa, Elena, Girardi, Cristina, Ribaudo, Giovanni, Salvi, Mauro, Zagotto, Giuseppe, Ruzzene, Maria, Pinna, Lorenzo A

“…By derivatizing the purely competitive CK2 inhibitor N1-(4,5,6,7-tetrabromo-1H-benzimidazol-2-yl)-propane-1,3-diamine (K137) at its 3-amino position with a…”
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The protein kinase CK2 contributes to the malignant phenotype of cholangiocarcinoma cells by Di Maira, Giovanni, Gentilini, Alessandra, Pastore, Mirella, Caligiuri, Alessandra, Piombanti, Benedetta, Raggi, Chiara, Rovida, Elisabetta, Lewinska, Monika, Andersen, Jesper B., Borgo, Christian, Salvi, Mauro, Ottaviani, Daniele, Ruzzene, Maria, Marra, Fabio

“…Cholangiocarcinoma (CCA) is a particularly aggressive hepatobiliary malignancy, for which the molecular mechanisms underlying the malignant phenotype are still…”
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The importance of negative determinants as modulators of CK2 targeting. The lesson of Akt2 S131 by Vilardell, Jordi, Girardi, Cristina, Marin, Oriano, Cozza, Giorgio, Pinna, Lorenzo A, Ruzzene, Maria

“…CK2 is a pleiotropic S/T protein kinase (formerly known as casein kinase 2) which is attracting increasing interest as therapeutic target, and the…”
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Effects of the CK2 inhibitors CX-4945 and CX-5011 on drug-resistant cells by Zanin, Sofia, Borgo, Christian, Girardi, Cristina, O'Brien, Sean E, Miyata, Yoshihiko, Pinna, Lorenzo A, Donella-Deana, Arianna, Ruzzene, Maria

“…CK2 is a pleiotropic protein kinase, which regulates many survival pathways and plays a global anti-apoptotic function. It is highly expressed in tumor cells,…”
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Protein Kinase CK2 Protects Multiple Myeloma Cells from ER Stress-Induced Apoptosis and from the Cytotoxic Effect of HSP90 Inhibition through Regulation of the Unfolded Protein Response by MANNI, Sabrina, BRANCALION, Alessandra, ADAMI, Fausto, ZAMBELLO, Renato, PITARI, Maria Rita, TASSONE, Pierfrancesco, PINNA, Lorenzo A, GURRIERI, Carmela, SEMENZATO, Gianpietro, PIAZZA, Francesco, LAURA QUOTTI TUBI, COLPO, Anna, PAVAN, Laura, CABRELLE, Anna, AVE, Elisa, ZAFFINO, Fortunato, MAIRA, Giovanni Di, RUZZENE, Maria

“…Protein kinase CK2 promotes multiple myeloma cell growth by regulating critical signaling pathways. CK2 also modulates proper HSP90-dependent client protein…”
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Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2) by Cozza, Giorgio, Zanin, Sofia, Determann, Renate, Ruzzene, Maria, Kunick, Conrad, Pinna, Lorenzo A

“…Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase controlling cell proliferation and survival, whose investigation has been hampered by the…”
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Enhancing chemosensitivity to gemcitabine via RNA interference targeting the catalytic subunits of protein kinase CK2 in human pancreatic cancer cells by Kreutzer, Jan N, Ruzzene, Maria, Guerra, Barbara

“…Pancreatic cancer is a complex genetic disorder that is characterized by rapid progression, invasiveness, resistance to treatment and high molecular…”
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Dephosphorylation and inactivation of Akt/PKB is counteracted by protein kinase CK2 in HEK 293T cells by Di Maira, Giovanni, Brustolon, Francesca, Pinna, Lorenzo A., Ruzzene, Maria

“…Akt (PKB) is a critical kinase in cell-survival pathways. Its activity depends on the phosphorylation of Thr308 and Ser473, by PDK1 and mTORC2, respectively…”
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Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells by Ruzzene, Maria, Penzo, Daniele, Pinna, Lorenzo A

“…Incubation of Jurkat cells with 4,5,6,7-tetrabromobenzotriazole (TBB), a specific inhibitor of protein kinase CK2, induces dose-and time-dependent apoptosis as…”
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