Search Results - "RUVOLO, P"

Galectin 3 as a guardian of the tumor microenvironment by Ruvolo, Peter P.

“…Galectin 3 is a member of a family of β-galactoside binding proteins and has emerged as an important regulator of diverse functions critical in cancer biology…”
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Role of protein phosphatases in the cancer microenvironment by Ruvolo, Peter P.

“…Cancer cells depend on a supportive niche (the tumor microenvironment) that promotes tumor cell survival while protecting the malignant cells from therapeutic…”
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The broken “Off” switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillance by Ruvolo, Peter P.

“…Aberrant activation of signal transduction pathways can transform a normal cell to a malignant one and can impart survival properties that render cancer cells…”
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Intracellular signal transduction pathways activated by ceramide and its metabolites by Ruvolo, Peter P.

“…The sphingolipid ceramide has proven to be a powerful second-signal effector molecule that regulates diverse cellular processes including apoptosis, cell…”
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Phosphorylation of Bcl2 and regulation of apoptosis by RUVOLO, P. P, DENG, X, MAY, W. S

“…Members of the Bcl2 family of proteins are important regulators of programmed cell death pathways with individual members that can suppress (eg Bcl2, Bcl-XL)…”
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Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia by Pan, Rongqing, Hogdal, Leah J, Benito, Juliana M, Bucci, Donna, Han, Lina, Borthakur, Gautam, Cortes, Jorge, DeAngelo, Daniel J, Debose, Lakeisha, Mu, Hong, Döhner, Hartmut, Gaidzik, Verena I, Galinsky, Ilene, Golfman, Leonard S, Haferlach, Torsten, Harutyunyan, Karine G, Hu, Jianhua, Leverson, Joel D, Marcucci, Guido, Müschen, Markus, Newman, Rachel, Park, Eugene, Ruvolo, Peter P, Ruvolo, Vivian, Ryan, Jeremy, Schindela, Sonja, Zweidler-McKay, Patrick, Stone, Richard M, Kantarjian, Hagop, Andreeff, Michael, Konopleva, Marina, Letai, Anthony G

“…B-cell leukemia/lymphoma 2 (BCL-2) prevents commitment to programmed cell death at the mitochondrion. It remains a challenge to identify those tumors that are…”
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Roles of the Ras Raf MEK ERK pathway in leukemia therapy by Steelman, L S, Franklin, R A, Abrams, S L, Chappell, W, Kempf, C R, Bäsecke, J, Stivala, F, Donia, M, Fagone, P, Nicoletti, F, Libra, M, Ruvolo, P, Ruvolo, V, Evangelisti, C, Martelli, A M, McCubrey, J A

“…The Ras/Raf/mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway is often implicated in sensitivity and resistance to…”
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LGALS1 acts as a pro-survival molecule in AML by Ruvolo, Peter P., Ma, Huaxian, Ruvolo, Vivian R., Zhang, Xiaorui, Post, Sean M., Andreeff, Michael

“…The galectin LGALS1 is a glycan binding protein that regulates intracellular (e.g. signal transduction) and extracellular processes (e.g. immunity, leukocyte…”
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TP53/miR-34a-associated signaling targets SERPINE1 expression in human pancreatic cancer by Akula, Shaw M, Ruvolo, Peter P, McCubrey, James A

“…Pancreatic ductal adenocarcinoma (PDAC) is a disease of aging. The gene product regulates cell growth, aging, and cancer. To determine the important targets of…”
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Targeting the translational apparatus to improve leukemia therapy: roles of the PI3K PTEN Akt mTOR pathway by Martelli, A M, Evangelisti, C, Chappell, W, Abrams, S L, Bäsecke, J, Stivala, F, Donia, M, Fagone, P, Nicoletti, F, Libra, M, Ruvolo, V, Ruvolo, P, Kempf, C R, Steelman, L S, McCubrey, J A

“…It has become apparent that regulation of protein translation is an important determinant in controlling cell growth and leukemic transformation. The…”
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Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia by Konopleva, Marina, Contractor, Rooha, Tsao, Twee, Samudio, Ismael, Ruvolo, Peter P., Kitada, Shinichi, Deng, Xingming, Zhai, Dayong, Shi, Yue-Xi, Sneed, Thomas, Verhaegen, Monique, Soengas, Maria, Ruvolo, Vivian R., McQueen, Teresa, Schober, Wendy D., Watt, Julie C., Jiffar, Tilahun, Ling, Xiaoyang, Marini, Frank C., Harris, David, Dietrich, Martin, Estrov, Zeev, McCubrey, James, May, W. Stratford, Reed, John C., Andreeff, Michael

“…BCL-2 proteins are critical for cell survival and are overexpressed in many tumors. ABT-737 is a small-molecule BH3 mimetic that exhibits single-agent activity…”
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AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill FLT3 -ITD acute myeloid leukemia by Post, Sean M, Ma, Huaxian, Malaney, Prerna, Zhang, Xiaorui, Aitken, Marisa J L, Mak, Po Yee, Ruvolo, Vivian R, Yasuhiro, Tomoko, Kozaki, Ryohei, Chan, Lauren E, Ostermann, Lauren B, Konopleva, Marina, Carter, Bing Z, DiNardo, Courtney, Andreeff, Michael D, Khoury, Joseph D, Ruvolo, Peter P

“…FMS-like Tyrosine Kinase 3 (FLT3) mutation is associated with poor survival in acute myeloid leukemia (AML). The specific Anexelekto/MER Tyrosine Kinase (AXL)…”
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Low expression of PP2A regulatory subunit B55α is associated with T308 phosphorylation of AKT and shorter complete remission duration in acute myeloid leukemia patients by Ruvolo, P P, Qui, Y H, Coombes, K R, Zhang, N, Ruvolo, V R, Borthakur, G, Konopleva, M, Andreeff, M, Kornblau, S M

“…The regulation of protein kinase B (AKT) is a dynamic process that depends on the balance between phosphorylation by upstream kinases for activation and…”
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Retraction Note: MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex by Konopleva, M., Milella, M., Ruvolo, P., Watts, J. C., Ricciardi, M. R., Korchin, B., Teresa, McQueen, Bornmann, William, Tsao, T., Bergamo, P., Mak, D. H., Chen, W., McCubrey, J., Tafuri, A., Andreeff, M.

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Ceramide regulates cellular homeostasis via diverse stress signaling pathways by RUVOLO, P. P

“…The sphingolipid ceramide is an important second signal molecule that regulates diverse signaling pathways involving apoptosis, cell senescence, the cell…”
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Distinct protein signatures of acute myeloid leukemia bone marrow-derived stromal cells are prognostic for patient survival by Kornblau, Steven M, Ruvolo, Peter P, Wang, Rui-Yu, Battula, V Lokesh, Shpall, Elizabeth J, Ruvolo, Vivian R, McQueen, Teresa, Qui, YiHua, Zeng, Zhihong, Pierce, Sherry, Jacamo, Rodrigo, Yoo, Suk-Young, Le, Phuong M, Sun, Jeffrey, Hail, Jr, Numsen, Konopleva, Marina, Andreeff, Michael

“…Mesenchymal stromal cells (MSC) support acute myeloid leukemia (AML) cell survival in the bone marrow (BM) microenvironment. Protein expression profiles of…”
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Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells by Ruvolo, Peter P., Ruvolo, Vivian R., Benton, Christopher B., AlRawi, Ahmed, Burks, Jared K., Schober, Wendy, Rolke, James, Tidmarsh, George, Hail, Numsen, Eric Davis, R., Andreeff, Michael

“…Galectin 3 (LGALS3) expression is prognostic for poor survival in acute myeloid leukemia (AML) patients. GCS-100 is a novel galectin inhibitor that may prove…”
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Preclinical and Early Clinical Evaluation of the Oral AKT Inhibitor, MK-2206, for the Treatment of Acute Myelogenous Leukemia by KONOPLEVA, Marina Y, WALTER, Roland B, HONGBO LU, DEBOSE, Lakiesha, BURGER, Jan A, ANDREEFF, Michael, WENBIN LIU, BAGGERLY, Keith A, KORNBLAU, Steven M, DOYLE, L. Austin, ESTEY, Elihu H, KANTARJIAN, Hagop M, FADERL, Stefan H, JABBOUR, Elias J, ZHIHONG ZENG, BORTHAKUR, Gautam, XUELIN HUANG, KADIA, Tapan M, RUVOLO, Peter P, FELIU, Jennie B

“…Recent studies suggested that AKT activation might confer poor prognosis in acute myelogenous leukemia (AML), providing the rationale for therapeutic targeting…”
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MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex by KONOPLEVA, M, MILELLA, M, MAK, D. H, CHEN, W, MCCUBREY, J, TAFURI, A, ANDREEFF, M, RUVOLO, P, WATTS, J. C, RICCIARDI, M. R, KORCHIN, B, MCQUEEN, T, BORNMANN, W, TSAO, T, BERGAMO, P

“…Recently, strategies for acute myeloid leukemia (AML) therapy have been developed that target anti-apoptotic BCL2 family members using BH3-mimetic drugs such…”
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The potential of enzastaurin to enhance platelet aggregation and growth factor secretion: implications for cancer cell survival by Lesyk, G., Fong, T., Ruvolo, P. P., Jurasz, P.

“…Summary Background Enzastaurin is a protein kinase C (PKC)β inhibitor with antiproliferative and proapoptotic effects that was in clinical development for the…”
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