Search Results - "RUVKUN, G"

Molecular biology. Glimpses of a tiny RNA world by Ruvkun, G

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The C. elegans DAF-2 insulin-like receptor is abundantly expressed in the nervous system and regulated by nutritional status by Kimura, K D, Riddle, D L, Ruvkun, G

“…A Caenorhabditis elegans insulin-like signaling pathway regulates development, metabolism, and longevity. We detected abundant DAF-2 insulin-like receptor…”
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Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System by Wolkow, Catherine A., Kimura, Koutarou D., Lee, Ming-Sum, Ruvkun, Gary

“…An insulinlike signaling pathway controls Caenorhabditis elegans aging, metabolism, and development. Mutations in the daf-2 insulin receptor-like gene or the…”
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A PDK1 homolog is necessary and sufficient to transduce AGE-1 PI3 kinase signals that regulate diapause in Caenorhabditis elegans by Paradis, S, Ailion, M, Toker, A, Thomas, J H, Ruvkun, G

“…An insulin receptor-like signaling pathway regulates Caenorhabditis elegans metabolism, development, and longevity. Inactivation of the insulin receptor…”
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daf-2, daf-16 and daf-23: Genetically Interacting Genes Controlling Dauer Formation in Caenorhabditis elegans by Gottlieb, S, Ruvkun, G

“…Under conditions of high population density and low food, Caenorhabditis elegans forms an alternative third larval stage, called the dauer stage, which is…”
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A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans by Morris, Jason Z, Tissenbaum, Heidi A, Ruvkun, Gary

“…A pheromone-induced neurosecretory pathway in Caenorhabditis elegans triggers developmental arrest and an increase in longevity at the dauer diapause stage…”
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A bulged lin-4/lin-14 RNA duplex is sufficient for Caenorhabditis elegans lin-14 temporal gradient formation by Ha, I, Wightman, B, Ruvkun, G

“…The Caenorhabditis elegans heterochronic gene lin-14 generates a temporal gradient of the LIN-14 proteins to control stage-specific patterns of cell lineage…”
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Alternative olfactory neuron fates are specified by the LIM homeobox gene lim-4 by Sagasti, A, Hobert, O, Troemel, E R, Ruvkun, G, Bargmann, C I

“…The Caenorhabditis elegans AWA, AWB, and AWC olfactory neurons are each required for the recognition of a specific subset of volatile odorants. lim-4 mutants…”
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Regulation of ectodermal and excretory function by the C. elegans POU homeobox gene ceh-6 by Bürglin, T R, Ruvkun, G

“…Caenorhabditis elegans has three POU homeobox genes, unc-86, ceh-6 and ceh-18. ceh-6 is the ortholog of vertebrate Brn1, Brn2, SCIP/Oct6 and Brn4 and fly…”
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The Caenorhabditis elegans lim-6 LIM homeobox gene regulates neurite outgrowth and function of particular GABAergic neurons by Hobert, O, Tessmar, K, Ruvkun, G

“…We describe here the functional analysis of the C. elegans LIM homeobox gene lim-6, the ortholog of the mammalian Lmx-1a and b genes that regulate limb, CNS,…”
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Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs by Hayes, G D, Ruvkun, G

“…The Caenorhabditis elegans microRNAs (miRNAs) lin-4 and let-7 promote transitions between stage-specific events in development by down-regulating the…”
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Identification of Caenorhabditis elegans genes regulating longevity using enhanced RNAi-sensitive strains by Samuelson, A V, Klimczak, R R, Thompson, D B, Carr, C E, Ruvkun, G

“…A systematic genome-wide RNA interference screen was performed in the Caenorhabditis elegans lin-15b;eri-1 strain, which has an enhanced response to…”
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Regulation of Caenorhabditis elegans RNA interference by the daf-2 insulin stress and longevity signaling pathway by Wang, D, Ruvkun, G

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The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products by HERR, W, STURM, R. A, HORVITZ, H. R, CLERC, R. G, CORCORAN, L. M, BALTIMORE, D, SHARP, P. A, INGRAHAM, H. A, ROSENFELD, M. G, FINNEY, M, RUVKUN, G

“…The authors describe a large, 150- to 160-amino-acid-long region of sequence similarity in the three mammalian proteins Pit-1, Oct-1, and Oct-2 and in the…”
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Clarifications on miRNA and Cancer by Ruvkun, Gary

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Regulation of the mec‐3 gene by the C.elegans homeoproteins UNC‐86 and MEC‐3 by Xue, D., Finney, M., Ruvkun, G., Chalfie, M.

“…The mec‐3 gene encodes a homeodomain protein with LIM repeats that is required for the specification of touch cell fate in Caenorhabditis elegans. Previous…”
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ω-6 Polyunsaturated fatty acids extend life span through the activation of autophagy by O'Rourke, Eyleen J, Kuballa, Petric, Xavier, Ramnik, Ruvkun, Gary

“…Adaptation to nutrient scarcity depends on the activation of metabolic programs to efficiently use internal reserves of energy. Activation of these programs in…”
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A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans by Ruvkun, Gary, Kennedy, Scott, Wang, Duo

“…In many organisms, introducing double-stranded RNA (dsRNA) causes the degradation of messenger RNA that is homologous to the trigger dsRNA-a process known as…”
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The Caenorhabditis elegans behavioral gene unc-24 encodes a novel bipartite protein similar to both erythrocyte band 7.2 (stomatin) and nonspecific lipid transfer protein by Barnes, T M, Jin, Y, Horvitz, H R, Ruvkun, G, Hekimi, S

“…We report here the positional cloning and molecular characterization of the unc-24 gene of Caenorhabditis elegans. This gene is required for normal locomotion…”
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DAF-16/FOXO and HLH-30/TFEB function as combinatorial transcription factors to promote stress resistance and longevity by Lin, Xin-Xuan, Sen, Ilke, Janssens, Georges E., Zhou, Xin, Fonslow, Bryan R., Edgar, Daniel, Stroustrup, Nicholas, Swoboda, Peter, Yates, John R., Ruvkun, Gary, Riedel, Christian G.

“…The ability to perceive and respond to harmful conditions is crucial for the survival of any organism. The transcription factor DAF-16/FOXO is central to these…”
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