Search Results - "RUTKOWSKI, Maria D"
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The Role of Spinal Neuroimmune Activation in Morphine Tolerance/Hyperalgesia in Neuropathic and Sham-Operated Rats
Published in The Journal of neuroscience (15-11-2002)“…Hypersensitivity resulting from nerve injury or morphine tolerance/hyperalgesia is predicted to involve similar cellular and molecular mechanisms. One expected…”
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Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines
Published in Pain (Amsterdam) (01-08-2003)“…Injury to peripheral nerves often produces non-physiological, long-lasting spontaneous pain, hyperalgesia and allodynia that are refractory to standard…”
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The magnitude of mechanical allodynia in a rodent model of lumbar radiculopathy is dependent on strain and sex
Published in Spine (Philadelphia, Pa. 1976) (15-08-2005)“…This study examined the differences in tactile hypersensitivity across 6 different strains of male mice, and between male and female rats of 3 different…”
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Lumbar nerve root injury induces central nervous system neuroimmune activation and neuroinflammation in the rat: Relationship to painful radiculopathy
Published in Spine (Philadelphia, Pa. 1976) (01-08-2002)“…These studies were designed to examine the role of central neuroimmune activation and neuroinflammation in a rat model of lumbar radiculopathy. In the present…”
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Transgenic expression of TNF by astrocytes increases mechanical allodynia in a mouse neuropathy model
Published in Neuroreport (28-02-2000)“…It has been hypothesized that increased expression of proinflammatory cytokines mediate a variety of central nervous system disorders such as multiple…”
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Repeated injury to the lumbar nerve roots produces enhanced mechanical allodynia and persistent spinal neuroinflammation
Published in Spine (Philadelphia, Pa. 1976) (01-10-2001)“…A lumbar radiculopathy model investigated pain behavioral responses after nerve root reinjury. To gain a further understanding of central sensitization and…”
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Quantification of neural tissue injury in a rat radiculopathy model: comparison of local deformation, behavioral outcomes, and spinal cytokine mRNA for two surgeons
Published in Journal of neuroscience methods (15-10-2001)“…Clinical and experimental work indicate that a variety of factors contribute to radicular pain mechanisms, including mechanical injury. While it has been…”
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Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain
Published in Brain research. Molecular brain research. (20-11-1998)“…Interleukin-6 (IL-6) is a multifunctional cytokine whose actions include modulation of proliferation, differentiation, and maturation of hemapoietic…”
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Nerve injury proximal or distal to the DRG induces similar spinal glial activation and selective cytokine expression but differential behavioral responses to pharmacologic treatment
Published in Journal of comparative neurology (1911) (15-10-2001)“…The specific mechanisms by which nervous system injury becomes a chronic pain state remain undetermined. Historically, it has been believed that injuries…”
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Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain
Published in Brain research (06-10-2000)“…Interleukin-6 (IL-6) is a pleiotrophic cytokine with a diverse range of actions including the modulation of the peripheral and central nervous system. We have…”
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Focal peripheral nerve injury induces leukocyte trafficking into the central nervous system: potential relationship to neuropathic pain
Published in Pain (Amsterdam) (01-11-2002)“…The present study was undertaken to determine whether leukocytes are recruited into the spinal cord following a peripheral L5 spinal nerve transection that…”
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Central administration of methotrexate reduces mechanical allodynia in an animal model of radiculopathy/sciatica
Published in Pain (Amsterdam) (01-08-2000)“…We have recently reported that injury to a lumbar root in a rat model of radiculopathy produces spinal glial activation associated with elevated…”
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Gender differences in rat neuropathic pain sensitivity is dependent on strain
Published in Neuroscience letters (24-03-2000)“…It is well recognized that gender differences play a major role in pain sensitivity, pain report, analgesic efficacy and prevalence of certain chronic pain…”
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Limited role of macrophages in generation of nerve injury-induced mechanical allodynia
Published in Physiology & behavior (01-11-2000)“…The purpose of this study was to investigate the role of peripheral macrophages in the generation of mechanical allodynia utilizing a modification of the Chung…”
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Cyclooxygenase-2 inhibitor SC-236 attenuates mechanical allodynia following nerve root injury in rats
Published in Journal of orthopaedic research (01-11-2000)“…Low back pain is a common problem, affecting approximately two-thirds of the adult population. Of these individuals, a significant percentage will exhibit…”
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The Role of Cytokines in the Initiation and Maintenance of Chronic Pain
Published in Drug news & perspectives (01-12-2002)“…Recent advancements in the pain field have identified a central nervous system (CNS) neuroimmune response that may act as the driving force for neuronal…”
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