Search Results - "RUTH, T. J"

Longitudinal progression of sporadic Parkinson's disease: a multi-tracer positron emission tomography study by Nandhagopal, R., Kuramoto, L., Schulzer, M., Mak, E., Cragg, J., Lee, Chong S., McKenzie, J., McCormick, S., Samii, A., Troiano, A., Ruth, T. J., Sossi, V., de la Fuente-Fernandez, R., Calne, Donald B., Stoessl, A. J.

“…Parkinson's disease is a heterogeneous disorder with multiple factors contributing to disease initiation and progression. Using serial, multi-tracer positron…”
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Progression of dopaminergic dysfunction in a LRRK2 kindred : A multitracer PET study by NANDHAGOPAL, R, MAK, E, STOESSL, A. J, SCHULZER, M, MCKENZIE, J, MCCORMICK, S, SOSSI, V, RUTH, T. J, STRONGOSKY, A, FARRER, M. J, WSZOLEK, Z. K

“…Little is known about the progression of dopaminergic dysfunction in LRRK2-associated Parkinson disease (PD). We sought to characterize the neurochemical…”
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PET demonstrates reduced dopamine transporter expression in PD with dyskinesias by TROIANO, A. R, DE LA FUENTE-FERNANDEZ, R, SOSSI, V, SCHULZER, M, MAK, E, RUTH, T. J, STOESSL, A. J

“…Dyskinesias are common in Parkinson disease (PD). Prior investigations suggest that dopamine (DA) terminals compensate for abnormal DA transmission. We…”
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Expectation and Dopamine Release: Mechanism of the Placebo Effect in Parkinson's Disease by de la Fuente-Fernández, Raúl, Ruth, Thomas J., Sossi, Vesna, Schulzer, Michael, Calne, Donald B., Stoessl, A. Jon

“…The power of placebos has long been recognized for improving numerous medical conditions such as Parkinson's disease (PD). Little is known, however, about the…”
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Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity by Wong, J. T, Kim, P. T. W, Peacock, J. W, Yau, T. Y, Mui, A. L.-F, Chung, S. W, Sossi, V, Doudet, D, Green, D, Ruth, T. J, Parsons, R, Verchere, C. B, Ong, C. J

“…Aims/hypothesis Insulin controls glucose metabolism via multiple signalling pathways, including the phosphatidylinositol 3-kinase (PI3K) pathway in muscle and…”
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Statistical list-mode image reconstruction for the high resolution research tomograph by Rahmim, A, Lenox, M, Reader, A J, Michel, C, Burbar, Z, Ruth, T J, Sossi, V

“…We have investigated statistical list-mode reconstruction applicable to a depth-encoding high resolution research tomograph. An image non-negativity constraint…”
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Micropet imaging: in vivo biochemistry in small animals by Sossi, V, Ruth, T J

“…Significant technological advancements required for imaging physiological function in small animals have been achieved in the last few years. Dedicated small…”
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In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease by Lee, Chong S., Samii, Ali, Sossi, Vesna, Ruth, Thomas J., Schulzer, Michael, Holden, James E., Wudel, Jess, Pal, Pramod K., De La Fuente-Fernandez, Raul, Calne, Donald B., Stoessl, A. Jon

“…Clinical symptoms of Parkinson's disease (PD) do not manifest until dopamine (DA) neuronal loss reaches a symptomatic threshold. To explore the mechanisms of…”
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Visualization of the flow of a fiber suspension through a sudden expansion using PET by Heath, S. J., Olson, J. A., Buckley, K. R., Lapi, S., Ruth, T. J., Martinez, D. M.

“…The motion of 18F radioactively labeled papermaking fibers flowing through an axisymmetric 1:5 sudden expansion has been studied using positron emission…”
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Immediate and delayed effects of risperidone on cerebral metabolism in neuroleptic naïve schizophrenic patients: correlations with symptom change by Ngan, E T C, Lane, C J, Ruth, T J, Liddle, P F

“…Objective: Different symptom patterns have been shown to be associated with specific patterns of cerebral metabolic activity in schizophrenia. Treatment with…”
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Understanding radionuclide production in gas target systems: the effect of adsorption on the target body by Zacchia, N A, Buckley, K R, Martinez, G M, Ruth, T J, Martinez, D M, Hoehr, C

“…Gas target systems have been used for decades on cyclotrons to produce radionuclides for medical imaging. However, the activity recovered from such targets is…”
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The medical isotope crisis: how we got here and where we are going by Ruth, Thomas J

“…(99m)Tc is the most widely used radionuclide in nuclear medicine. The reactor stoppages that occurred in recent years illustrated the vulnerability of the…”
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Evaluation of 209 At as a theranostic isotope for 209 At-radiopharmaceutical development using high-energy SPECT by Crawford, J R, Robertson, A K H, Yang, H, Rodríguez-Rodríguez, C, Esquinas, P L, Kunz, P, Blinder, S, Sossi, V, Schaffer, P, Ruth, T J

“…The development of alpha-emitting radiopharmaceuticals using At requires quantitative determination of the time-dependent nature of the At biodistribution…”
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The sedimentation of papermaking fibers by Young, E. W. K., Martinez, D. M., Olson, J. A., Buckley, K., Jivan, S., Ruth, T. J., Sossi, V.

“…The motion of 18F radioactively labeled papermaking fibers settling in the midst of a suspension of nonradioactive fibers has been studied using positron…”
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Feedback Regulation of Nitrate Influx in Barley Roots by Nitrate, Nitrite, and Ammonium by Bryan J. King, Siddiqi, M. Yaeesh, Ruth, Thomas J., Warner, Robert L., Anthony D. M. Glass

“…The short-lived radiotracer ^{13}\text{N}$ was used to study feedback regulation of nitrate influx through the inducible high-affinity transport system of…”
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A fast and simple dose-calibrator-based quality control test for the radionuclidic purity of cyclotron-produced (99m)Tc by Tanguay, J, Hou, X, Esquinas, P, Vuckovic, M, Buckley, K, Schaffer, P, Bénard, F, Ruth, T J, Celler, A

“…Cyclotron production of 99mTc through the (100)Mo(p,2n)99mTc reaction channel is actively being investigated as an alternative to reactor-based (99)Mo…”
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Nigrostriatal dopamine system and motor lateralization by de la Fuente-Fernández, Raúl, Kishore, Asha, Calne, Donald B, Ruth, Thomas J, Stoessl, A.Jon

“…The mechanism by which most people favor use of the right hand remains unknown. It has been proposed that asymmetries in the nigrostriatal dopamine system may…”
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Correlation of striatal fluorodopa uptake in the MPTP monkey with dopaminergic indices by Pate, B D, Kawamata, T, Yamada, T, McGeer, E G, Hewitt, K A, Snow, B J, Ruth, T J, Calne, D B

“…Striatal 18F-6-fluorodopa (FD) uptake constants were measured by positron emission tomography in (1) normal cynomolgus monkeys and (2) a series of cynomolgus…”
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Evaluation of Dopaminergic Presynaptic Integrity: 6-[18F]Fluoro-L-Dopa Versus 6-[18F]Fluoro-L-m-Tyrosine by Doudet, D. J., Chan, G. L.-Y., Jivan, S., DeJesus, O. T., McGeer, E. G., English, C., Ruth, T. J., Holden, J. E.

“…The effectiveness of 6-[18F]fluoro-L-m-tyrosine (6FMT) to evaluate dopamine presynaptic integrity was compared to that of 6-[18F]fluoro-L-dopa (6FDOPA) in vivo…”
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Striatal D2 receptors in symptomatic and asymptomatic carriers of dopa-responsive dystonia measured with [11C]-raclopride and positron-emission tomography by KISHORE, A, NYGAARD, T. G, DE LA FUENTE-FERNANDEZ, R, NAINI, A. B, SCHULZER, M, MAK, E, RUTH, T. J, CALNE, D. B, SNOW, B. J, STOESSL, A. J

“…We tested the hypothesis that asymptomatic carriers of dopa-responsive dystonia (DRD) have increased dopamine D2 receptors in the striatum that protect them…”
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