Search Results - "RUTH, Peter"
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cGMP and mitochondrial K+ channels—Compartmentalized but closely connected in cardioprotection
Published in British journal of pharmacology (01-06-2022)“…The 3′,5′‐cGMP pathway triggers cytoprotective responses and improves cardiomyocyte survival during myocardial ischaemia and reperfusion (I/R) injury. These…”
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Cardioprotection by ischemic postconditioning and cyclic guanosine monophosphate-elevating agents involves cardiomyocyte nitric oxide-sensitive guanylyl cyclase
Published in Cardiovascular research (01-05-2018)“…Abstract Aims It has been suggested that the nitric oxide-sensitive guanylyl cyclase (NO-GC)/cyclic guanosine monophosphate (cGMP)-dependent signalling pathway…”
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cGMP-Elevating Compounds and Ischemic Conditioning Provide Cardioprotection Against Ischemia and Reperfusion Injury via Cardiomyocyte-Specific BK Channels
Published in Circulation (New York, N.Y.) (12-12-2017)“…BACKGROUND:The nitric oxide–sensitive guanylyl cyclase/cGMP-dependent protein kinase type I signaling pathway can afford protection against the…”
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Mice with deficient BK channel function show impaired prepulse inhibition and spatial learning, but normal working and spatial reference memory
Published in PloS one (26-11-2013)“…Genetic variations in the large-conductance, voltage- and calcium activated potassium channels (BK channels) have been recently implicated in mental…”
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Antimicrobial prescriptions in cats in Switzerland before and after the introduction of an online antimicrobial stewardship tool
Published in BMC veterinary research (03-07-2020)“…Antimicrobial stewardship activities are essential to improve prudent antimicrobial use. The aim of the present study was to evaluate changes in antimicrobial…”
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Distinct Acyl Protein Transferases and Thioesterases Control Surface Expression of Calcium-activated Potassium Channels
Published in The Journal of biological chemistry (27-04-2012)“…Protein palmitoylation is rapidly emerging as an important determinant in the regulation of ion channels, including large conductance calcium-activated…”
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Efficacy of combined tumor irradiation and KCa3.1-targeting with TRAM-34 in a syngeneic glioma mouse model
Published in Scientific reports (23-11-2023)“…The intermediate-conductance calcium-activated potassium channel K Ca 3.1 has been proposed to be a new potential target for glioblastoma treatment. This study…”
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Endothelial dysfunction and blood pressure alterations in K+-channel transgenic mice
Published in Pflügers Archiv (01-05-2010)“…K + channels are important regulators of arterial tone by providing membrane hyperpolarization and thus counteracting the activity of voltage-gated Ca 2+…”
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Physiological and Pathophysiological Roles of Metabolic Pathways for NET Formation and Other Neutrophil Functions
Published in Frontiers in immunology (09-02-2022)“…Neutrophils are the most numerous cells in the leukocyte population and essential for innate immunity. To limit their effector functions, neutrophils are able…”
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Effect of antimicrobial stewardship on antimicrobial prescriptions for selected diseases of dogs in Switzerland
Published in Journal of veterinary internal medicine (01-11-2020)“…Background Antimicrobial stewardship programs (ASPs) are important tools to foster prudent antimicrobial use. Objective To evaluate antimicrobial prescriptions…”
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Comparison of antimicrobial prescription patterns in calves in Switzerland before and after the launch of online guidelines for prudent antimicrobial use
Published in BMC veterinary research (05-01-2021)“…The increasing threat of bacterial resistance promotes the need for antibiotic stewardship programs to foster responsible antimicrobial use. Therefore,…”
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pH influence on antibacterial efficacy of common antiseptic substances
Published in Skin pharmacology and physiology (01-01-2015)“…Wound infection plays an important role in compromised wound healing. A high bioburden impairs healing and leads to formation of a chronic wound. Distinctly…”
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Glucocorticoids Inhibit CRH/AVP-Evoked Bursting Activity of Male Murine Anterior Pituitary Corticotrophs
Published in Endocrinology (Philadelphia) (01-08-2016)“…Corticotroph cells from the anterior pituitary are an integral component of the hypothalamic-pituitary-adrenal (HPA) axis, which governs the neuroendocrine…”
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IKCa channels control breast cancer metabolism including AMPK-driven autophagy
Published in Cell death & disease (27-10-2022)“…Ca 2+ -activated K + channels of intermediate conductance (IK) are frequently overexpressed in breast cancer (BC) cells, while IK channel depletion reduces BC…”
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Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells
Published in The Journal of neuroscience (29-05-2013)“…The encoding of auditory information with indefatigable precision requires efficient resupply of vesicles at inner hair cell (IHC) ribbon synapses. Otoferlin,…”
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Slack K+ channels limit kainic acid-induced seizure severity in mice by modulating neuronal excitability and firing
Published in Communications biology (11-10-2023)“…Mutations of the Na + -activated K + channel Slack ( KCNT1 ) are associated with terrible epilepsy syndromes that already begin in infancy. Here we report…”
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Dual role of protein kinase C on BK channel regulation
Published in Proceedings of the National Academy of Sciences - PNAS (27-04-2010)“…Large conductance voltage- and Ca²⁺-activated potassium channels (BK channels) are important feedback regulators in excitable cells and are potently regulated…”
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Functional Coupling of Slack Channels and P2X3 Receptors Contributes to Neuropathic Pain Processing
Published in International journal of molecular sciences (02-01-2021)“…The sodium-activated potassium channel Slack (K 1.1, Slo2.2, or Kcnt1) is highly expressed in populations of sensory neurons, where it mediates the…”
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Palmitoylation and Membrane Association of the Stress Axis Regulated Insert (STREX) Controls BK Channel Regulation by Protein Kinase C
Published in The Journal of biological chemistry (14-09-2012)“…Large-conductance, calcium- and voltage-gated potassium (BK) channels play an important role in cellular excitability by controlling membrane potential and…”
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Cyclic GMP-Dependent Regulation of Vascular Tone and Blood Pressure Involves Cysteine-Rich LIM-Only Protein 4 (CRP4)
Published in International journal of molecular sciences (14-09-2021)“…The cysteine-rich LIM-only protein 4 (CRP4), a LIM-domain and zinc finger containing adapter protein, has been implicated as a downstream effector of the…”
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