Search Results - "RUSSO, Leileata M"

Massively parallel sequencing of human urinary exosome/microvesicle RNA reveals a predominance of non-coding RNA by Miranda, Kevin C, Bond, Daniel T, Levin, Joshua Z, Adiconis, Xian, Sivachenko, Andrey, Russ, Carsten, Brown, Dennis, Nusbaum, Chad, Russo, Leileata M

“…Intact RNA from exosomes/microvesicles (collectively referred to as microvesicles) has sparked much interest as potential biomarkers for the non-invasive…”
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Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease by Miranda, Kevin C., Bond, Daniel T., McKee, Mary, Skog, Johan, Păunescu, Teodor G., Da Silva, Nicolas, Brown, Dennis, Russo, Leileata M.

“…Urinary exosomes or microvesicles are being studied intensively to identify potential new biomarkers for renal disease. We sought to identify whether these…”
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Impaired Tubular Uptake Explains Albuminuria in Early Diabetic Nephropathy by RUSSO, Leileata M, SANDOVAL, Ruben M, CAMPOS, Silvia B, MOLITORIS, Bruce A, COMPER, Wayne D, BROWN, Dennis

“…Understanding the pathogenesis of albuminuria in diabetic nephropathy is important to improve methods for early diagnosis and treatment. In this study, we…”
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Disease-dependent mechanisms of albuminuria by Comper, Wayne D, Hilliard, Lucinda M, Nikolic-Paterson, David J, Russo, Leileata M

“…The mechanism of albuminuria is perhaps one of the most complex yet important questions in renal physiology today. Recent studies have directly demonstrated…”
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cAMP stimulates apical V-ATPase accumulation, microvillar elongation, and proton extrusion in kidney collecting duct A-intercalated cells by Păunescu, Teodor G, Ljubojevic, Marija, Russo, Leileata M, Winter, Christian, McLaughlin, Margaret M, Wagner, Carsten A, Breton, Sylvie, Brown, Dennis

“…Kidney proton-secreting A-intercalated cells (A-IC) respond to systemic acidosis by accumulating the vacuolar ATPase (V-ATPase) in their apical membrane and by…”
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Renal handling of albumin: A critical review of basic concepts and perspective by Russo, Leileata M., Bakris, George L., Comper, Wayne D.

“…Biochemical and physiological processes that underlie the mechanism of albuminuria are completely reassessed in this article in view of recent discoveries that…”
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Compensatory membrane expression of the V-ATPase B2 subunit isoform in renal medullary intercalated cells of B1-deficient mice by Paunescu, Teodor G, Russo, Leileata M, Da Silva, Nicolas, Kovacikova, Jana, Mohebbi, Nilufar, Van Hoek, Alfred N, McKee, Mary, Wagner, Carsten A, Breton, Sylvie, Brown, Dennis

“…Mice deficient in the ATP6V1B1 ("B1") subunit of the vacuolar proton-pumping ATPase (V-ATPase) maintain body acid-base homeostasis under normal conditions, but…”
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Urine Exosomes for Non-Invasive Assessment of Gene Expression and Mutations of Prostate Cancer by Motamedinia, Piruz, Scott, Anna N, Bate, Kendall L, Sadeghi, Neda, Salazar, Guillermo, Shapiro, Edan, Ahn, Jennifer, Lipsky, Michael, Lin, James, Hruby, Greg W, Badani, Ketan K, Petrylak, Daniel P, Benson, Mitchell C, Donovan, Michael J, Comper, Wayne D, McKiernan, James M, Russo, Leileata M

“…The analysis of exosome/microvesicle (extracellular vesicles (EVs)) and the RNA packaged within them (exoRNA) has the potential to provide a non-invasive…”
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Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment by Bouley, Richard, Hawthorn, Gayle, Russo, Leileata M., Lin, Herbert Y., Ausiello, Dennis A., Brown, Dennis

“…Background information. Aquaporin 2 (AQP2) plays an important, VP (vasopressin)‐regulated role in water reabsorption by the kidney. The amount of AQP2…”
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Identification of a Novel Natriuretic Protein in Patients With Cerebral-Renal Salt Wasting—Implications for Enhanced Diagnosis by Maesaka, John K., Imbriano, Louis J., Pinkhasov, Aaron, Muralidharan, Rajanandini, Song, Xiaomin, Russo, Leileata M., Comper, Wayne D.

“…The most vexing problem in hyponatremic conditions is to differentiate the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) from…”
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Evidence for a role of transforming growth factor (TGF)-β1 in the induction of postglomerular albuminuria in diabetic nephropathy : Amelioration by soluble TGF-β type II receptor by RUSSO, Leileata M, DEL RE, Elisabetta, BROWN, Dennis, LIN, Herbert Y

“…Transforming growth factor-β (TGF-β) has previously been implicated in the progression of diabetic nephropathy, including the onset of fibrosis and…”
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Reduced tubular cation transport in diabetes: Prevented by ACE inhibition by Thomas, Merlin C., Tikellis, Chris, Burns, Wendy C., Thallas, Vicki, Forbes, Josephine M., Cao, Zemin, Osicka, Tanya M., Russo, Leileata M., Jerums, George, Ghabrial, Hany, Cooper, Mark E., Kantharidis, Phillip

“…Reduced tubular cation transport in diabetes: Prevented by ACE inhibition. The renal clearance of organic cations is important for the homeostasis of a number…”
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Albuminuria associated with CD2AP knockout mice is primarily due to dysfunction of the renal degradation pathway processing of filtered albumin by Russo, Leileata M., Srivatsan, Subhashini, Seaman, Matthew, Suleiman, Hani, Shaw, Andrey S., Comper, Wayne D.

“…•Mutations to components of the glomerular filter give rise to albuminuria.•It is thought that these mutations alter the permeability of the filter.•We show…”
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The glomerular filter: an imperfect barrier is required for perfect renal function by Comper, Wayne D, Russo, Leileata M

“…PURPOSE OF REVIEWThere is currently a major debate on the mechanisms of albuminuria, and this review appraises recent studies in this area. RECENT FINDINGSThe…”
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Methyl-beta-cyclodextrin induces vasopressin-independent apical accumulation of aquaporin-2 in the isolated, perfused rat kidney by Russo, Leileata M, McKee, Mary, Brown, Dennis

“…Vasopressin increases urine concentration by stimulating plasma membrane accumulation of aquaporin-2 (AQP2) in collecting duct principal cells, allowing bulk…”
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Vasopressin induces apical expression of caveolin in rat kidney collecting duct principal cells by Păunescu, Teodor G, Lu, Hua A J, Russo, Leileata M, Pastor-Soler, Núria M, McKee, Mary, McLaughlin, Margaret M, Bartlett, Bianca E, Breton, Sylvie, Brown, Dennis

“…Caveolin (Cav)1 is expressed in the basolateral membrane domain of renal collecting duct (CD) principal cells (PCs), where it is associated with caveolae. To…”
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Association of soluble adenylyl cyclase with the V-ATPase in renal epithelial cells by Paunescu, Teodor G, Da Silva, Nicolas, Russo, Leileata M, McKee, Mary, Lu, Hua A J, Breton, Sylvie, Brown, Dennis

“…Activation of soluble adenylyl cyclase (sAC) by bicarbonate causes local cAMP generation, indicating that sAC might act as a pH and/or bicarbonate sensor in…”
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The soluble transforming growth factor-β receptor: Advantages and applications by Russo, Leileata M., Brown, Dennis, Lin, Herbert Y.

“…Transforming growth factor-beta (TGF-β) is a cytokine that plays a pivotal role in growth, differentiation, development, immune response and wound healing…”
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Where does albuminuria come from in diabetic kidney disease? by Comper, Wayne D., Russo, Leileata M.

“…The classic mechanism to explain albumin excretion in diabetes has been permeability defects in the glomerular filter. However, a new concept has emerged that…”
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Hypertension-mediated albuminuria is associated with reduced lysosomal activity in the kidney and the heart by Hilliard, Lucinda M, Russo, Leileata M, Comper, Wayne D

“…Recent studies suggest that expression of the transforming growth factor-beta (TGF-beta)-inducible gene-h3 (betaig-h3) and its anti-lysosomal activity may be…”
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