Search Results - "RUSSELL, Chris B"

Multiyear Follow-up of AAV5-hFVIII-SQ Gene Therapy for Hemophilia A by Pasi, K. John, Rangarajan, Savita, Mitchell, Nina, Lester, Will, Symington, Emily, Madan, Bella, Laffan, Michael, Russell, Chris B, Li, Mingjin, Pierce, Glenn F, Wong, Wing Y

“…In 15 participants with hemophilia A treated with a single infusion of AAV5 vector containing the factor VIII gene, 7 who received 6×10 13 vector genomes per…”
Get full text

The IL-23/T17 pathogenic axis in psoriasis is amplified by keratinocyte responses by Lowes, Michelle A, Russell, Chris B, Martin, David A, Towne, Jennifer E, Krueger, James G

“…Psoriasis is a complex inflammatory process resulting from activation of the well-defined interleukin (IL)-23/T17 cytokine axis. We review the role of key…”
Get full text

The Emerging Role of IL-17 in the Pathogenesis of Psoriasis: Preclinical and Clinical Findings by Martin, David A., Towne, Jennifer E., Kricorian, Gregory, Klekotka, Paul, Gudjonsson, Johann E., Krueger, James G., Russell, Chris B.

“…Although the histological changes seen in psoriasis have long been well characterized, the underlying cellular and molecular mechanisms have only begun to be…”
Get full text

Interindividual variability in transgene mRNA and protein production following adeno-associated virus gene therapy for hemophilia A by Fong, Sylvia, Yates, Bridget, Sihn, Choong-Ryoul, Mattis, Aras N., Mitchell, Nina, Liu, Su, Russell, Chris B., Kim, Benjamin, Lawal, Adebayo, Rangarajan, Savita, Lester, Will, Bunting, Stuart, Pierce, Glenn F., Pasi, K. John, Wong, Wing Yen

“…Factor VIII gene transfer with a single intravenous infusion of valoctocogene roxaparvovec (AAV5-hFVIII-SQ) has demonstrated clinical benefits lasting 5 years…”
Get full text

Short-term transcriptional response to IL-17 receptor-A antagonism in the treatment of psoriasis by Tomalin, Lewis E., Russell, Chris B., Garcet, Sandra, Ewald, David Adrian, Klekotka, Paul, Nirula, Ajay, Norsgaard, Hanne, Suàrez-Fariñas, Mayte, Krueger, James G.

“…IL-17 antagonists induce impressive clinical benefits in psoriasis, but it is unknown to what extent cellular and molecular psoriasis characteristics are…”
Get full text

Distinguishing Molecular Features of Allergic Fungal Rhinosinusitis by Tyler, Matthew A., Padro Dietz, Caroline J., Russell, Chris B., Citardi, Martin J., Assassi, Shervin, Ying, Jun, Luong, Amber U.

“…Objective Allergic fungal rhinosinusitis (AFRS) is a clinical subtype of chronic rhinosinusitis with nasal polyps (CRSwNP), characterized by eosinophilic…”
Get full text

Large scale gene expression profiling reveals distinct type 2 inflammatory patterns in chronic rhinosinusitis subtypes by Tyler, Matthew A., MD, Russell, Chris B., PhD, Smith, Dirk E., MSc, Rottman, James B., DVM, PhD, Padro Dietz, Caroline J., PhD, Hu, Xuguang, PhD, Citardi, Martin J., MD, Fakhri, Samer, MD, Assassi, Shervin, MD, Luong, Amber, MD, PhD

“…In an attempt to better classify molecular profiles in chronic rhinosinusitis (CRS)subtypes and promote endotyping, we characterize the expression of relevant…”
Get full text

A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis by Martin, David A, Churchill, Melvin, Flores-Suarez, Luis, Cardiel, Mario H, Wallace, Daniel, Martin, Richard, Phillips, Kristine, Kaine, Jeffrey L, Dong, Hua, Salinger, David, Stevens, Erin, Russell, Chris B, Chung, James B

“…The aim of this study was to evaluate the safety, pharmacokinetics, and clinical response of brodalumab (AMG 827), a human, anti-IL-17 receptor A (IL-17RA)…”
Get full text

Molecular analysis of AAV5-hFVIII-SQ vector-genome-processing kinetics in transduced mouse and nonhuman primate livers by Sihn, Choong-Ryoul, Handyside, Britta, Liu, Su, Zhang, Lening, Murphy, Ryan, Yates, Bridget, Xie, Lin, Torres, Richard, Russell, Chris B., O'Neill, Charles A., Pungor, Erno, Bunting, Stuart, Fong, Sylvia

“…Valoctocogene roxaparvovec (AAV5-hFVIII-SQ) is an adeno-associated virus serotype 5 (AAV5)-based gene therapy vector containing a B-domain-deleted human…”
Get full text

Cellular responses to individual amino-acid depletion in antibody-expressing and parental CHO cell lines by Fomina-Yadlin, Dina, Gosink, John J., McCoy, Rebecca, Follstad, Brian, Morris, Arvia, Russell, Chris B., McGrew, Jeffrey T.

“…ABSTRACT Depletion of two nonessential amino acids, asparagine (Asn) and glutamine (Gln), occurred during a fed‐batch production process with a CHO cell line…”
Get full text

Multiyear Follow-up of AAV5-hFVIII-SQ Gene Therapy for Hemophilia A by Pasi, K John, Rangarajan, Savita, Mitchell, Nina, Lester, Will, Symington, Emily, Madan, Bella, Laffan, Michael, Russell, Chris B, Li, Mingjin, Pierce, Glenn F, Wong, Wing Y

“…Adeno-associated virus (AAV)-mediated gene therapy is under investigation as a therapeutic option for persons with hemophilia A. Efficacy and safety data…”
Get full text

Neurofilament light is a treatment‐responsive biomarker in CLN2 disease by Ru, Yuanbin, Corado, Carley, Soon, Russell K., Melton, Andrew C., Harris, Adam, Yu, Guoying K., Pryer, Nancy, Sinclair, John R., Katz, Martin L., Ajayi, Temitayo, Jacoby, David, Russell, Chris B., Chandriani, Sanjay

“…Objective Neuronal ceroid lipofuscinosis type 2 (CLN2 disease) is a rare, progressive, fatal neurodegenerative pediatric disorder resulting from deficiencies…”
Get full text

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis by Papp, Kim A, Leonardi, Craig, Menter, Alan, Ortonne, Jean-Paul, Krueger, James G, Kricorian, Gregory, Aras, Girish, Li, Juan, Russell, Chris B, Thompson, Elizabeth H.Z, Baumgartner, Scott

“…In this 12-week, phase 2 trial, an anti–interleukin-17–receptor antibody was effective in treating moderate-to-severe psoriasis. Adverse events included…”
Get full text

Gene expression profiles normalized in psoriatic skin by treatment with brodalumab, a human anti-IL-17 receptor monoclonal antibody by Russell, Chris B, Rand, Hugh, Bigler, Jeannette, Kerkof, Keith, Timour, Martin, Bautista, Edgar, Krueger, James G, Salinger, David H, Welcher, Andrew A, Martin, David A

“…The IL-17 pathway is an established driver of psoriasis pathogenesis. We examined the detailed molecular and cellular effects of blockade of IL-17 signaling in…”
Get full text

Brief Report: Pharmacodynamics, Safety, and Clinical Efficacy of AMG 811, a Human Anti–Interferon‐γ Antibody, in Patients With Discoid Lupus Erythematosus by Werth, Victoria P., Fiorentino, David, Sullivan, Barbara A., Boedigheimer, Michael J., Chiu, Kit, Wang, Christine, Arnold, Gregory E., Damore, Michael A., Bigler, Jeannette, Welcher, Andrew A., Russell, Chris B., Martin, David A., Chung, James B.

“…Objective Interferon‐γ (IFNγ) is implicated in the pathogenesis of discoid lupus erythematosus (DLE). This study sought to evaluate a single dose of AMG 811,…”
Get full text

Effect of IL-17 receptor A blockade with brodalumab in inflammatory diseases by Nirula, Ajay, Nilsen, Jon, Klekotka, Paul, Kricorian, Greg, Erondu, Ngozi, Towne, Jennifer E, Russell, Chris B, Martin, David A, Budelsky, Alison L

“…IL-17 cytokines are expressed by a variety of cells and mediate host defence against extracellular pathogens. IL-17 is upregulated at sites of inflammation and…”
Get full text

Long‐term safety and efficacy outcomes of valoctocogene roxaparvovec gene transfer up to 6 years post‐treatment by Symington, Emily, Rangarajan, Savita, Lester, Will, Madan, Bella, Pierce, Glenn F., Raheja, Priyanka, Robinson, Tara M., Osmond, Dane, Russell, Chris B., Vettermann, Christian, Agarwal, Suresh K., Li, Mingjin, Wong, Wing Yen, Laffan, Michael

“…Introduction Valoctocogene roxaparvovec uses an adeno‐associated virus serotype 5 (AAV5) vector to transfer a factor VIII (FVIII) coding sequence to…”
Get full text

Anti-IL-17 Receptor Antibody AMG 827 Leads to Rapid Clinical Response in Subjects with Moderate to Severe Psoriasis: Results from a Phase I, Randomized, Placebo-Controlled Trial by Papp, Kim A., Reid, Cathy, Foley, Peter, Sinclair, Rod, Salinger, David H., Williams, Gary, Dong, Hua, Krueger, James G., Russell, Chris B., Martin, David A.

Get full text

Blood biodistribution and vector shedding of valoctocogene roxaparvovec in people with severe hemophilia A by Agarwal, Suresh, Sandza, Krystal, Obrochta Moss, Kristin, Vora, Monica, Bowen, Alisa, Bunch, Brenna, Holcomb, Jennifer, Robinson, Tara M., Jayaram, Kala, Russell, Chris B., Zoog, Stephen, Vettermann, Christian, Henshaw, Joshua

“…•After valoctocogene roxaparvovec treatment, total and encapsidated vector DNA are steadily cleared from the blood and shedding matrixes.•Risk of horizontal or…”
Get full text

Evidence for Endotoxin Contamination in Plastic Na+-Heparin Blood Collection Tube Lots by NEWHALL, Kathryn J, DIEMER, Geoffrey S, LESHINSKY, Natalia, KERKOF, Keith, CHUTE, Hilary T, RUSSELL, Chris B, REES, William, WELCHER, Andrew A, PATTERSON, Scott D, MEANS, Gary D

“…Biomarker assays are often conducted on whole blood samples in the course of drug development studies. Because bacterial lipopolysaccharide (LPS) (endotoxin)…”
Get full text