Search Results - "RUSSELL, Angela J"

Structure-based development of new RAS-effector inhibitors from a combination of active and inactive RAS-binding compounds by Cruz-Migoni, Abimael, Canning, Peter, Quevedo, Camilo E., Bataille, Carole J. R., Bery, Nicolas, Miller, Ami, Russell, Angela J., Phillips, Simon E. V., Carr, Stephen B., Rabbitts, Terence H.

“…The RAS gene family is frequently mutated in human cancers, and the quest for compounds that bind to mutant RAS remains a major goal, as it also does for…”
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Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment by Quevedo, Camilo E., Cruz-Migoni, Abimael, Bery, Nicolas, Miller, Ami, Tanaka, Tomoyuki, Petch, Donna, Bataille, Carole J. R., Lee, Lydia Y. W., Fallon, Phillip S., Tulmin, Hanna, Ehebauer, Matthias T., Fernandez-Fuentes, Narcis, Russell, Angela J., Carr, Stephen B., Phillips, Simon E. V., Rabbitts, Terence H.

“…Targeting specific protein–protein interactions (PPIs) is an attractive concept for drug development, but hard to implement since intracellular antibodies do…”
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Combining experimental strategies for successful target deconvolution by Wilkinson, Isabel V.L., Terstappen, Georg C., Russell, Angela J.

“…•Target deconvolution can enhance pharmaceutical R&D productivity.•A combination of approaches is usually required for successful target deconvolution.•Target…”
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Activation of the Immune-Metabolic Receptor GPR84 Enhances Inflammation and Phagocytosis in Macrophages by Recio, Carlota, Lucy, Daniel, Purvis, Gareth S D, Iveson, Poppy, Zeboudj, Lynda, Iqbal, Asif J, Lin, Daniel, O'Callaghan, Chris, Davison, Lucy, Griesbach, Esther, Russell, Angela J, Wynne, Graham M, Dib, Lea, Monaco, Claudia, Greaves, David R

“…GPR84 is a member of the metabolic G protein-coupled receptor family, and its expression has been described predominantly in immune cells. GPR84 activation is…”
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Augmentation of Creatine in the Heart by Zervou, Sevasti, Whittington, Hannah J, Russell, Angela J, Lygate, Craig A

“…Creatine is a principle component of the creatine kinase (CK) phosphagen system common to all vertebrates. It is found in excitable cells, such as…”
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20 Years an Orphan: Is GPR84 a Plausible Medium-Chain Fatty Acid-Sensing Receptor? by Luscombe, Vincent B, Lucy, Daniel, Bataille, Carole J R, Russell, Angela J, Greaves, David R

“…GPR84 is an inflammation-induced receptor highly expressed on immune cells, yet its endogenous ligand is still unknown. This makes any interpretation of its…”
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DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo by LI, Ji-Liang, SAINSON, Richard C. A, WU, Herren, CHOWDHURY, Partha S, RUSSELL, Angela J, MONTGOMERY, Craig P, POULSOM, Richard, HARRIS, Adrian L, EIN OON, Chern, TURLEY, Helen, LEEK, Russell, SHELDON, Helen, BRIDGES, Esther, SHI, Wen, SNELL, Cameron, BOWDEN, Emma T

“…Resistance to VEGF inhibitors is emerging as a major clinical problem. Notch signaling has been implicated in tumor angiogenesis. Therefore, to investigate…”
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The BET inhibitor CPI203 promotes ex vivo expansion of cord blood long-term repopulating HSCs and megakaryocytes by Hua, Peng, Hester, Joanna, Adigbli, George, Li, Rong, Psaila, Bethan, Roy, Anindita, Bataille, Carole J.R., Wynne, Graham M., Jackson, Thomas, Milne, Thomas A., Russell, Angela J., Davies, James, Roberts, Irene, Issa, Fadi, Watt, Suzanne M.

“…Although cytokine-mediated expansion of human hematopoietic stem cells (HSCs) can result in high yields of hematopoietic progenitor cells, this generally…”
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Optimization of 3,5-Dimethylisoxazole Derivatives as Potent Bromodomain Ligands by Hewings, David S, Fedorov, Oleg, Filippakopoulos, Panagis, Martin, Sarah, Picaud, Sarah, Tumber, Anthony, Wells, Christopher, Olcina, Monica M, Freeman, Katherine, Gill, Andrew, Ritchie, Alison J, Sheppard, David W, Russell, Angela J, Hammond, Ester M, Knapp, Stefan, Brennan, Paul E, Conway, Stuart J

“…The bromodomain protein module, which binds to acetylated lysine, is emerging as an important epigenetic therapeutic target. We report the structure-guided…”
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Chemical Proteomics and Phenotypic Profiling Identifies the Aryl Hydrocarbon Receptor as a Molecular Target of the Utrophin Modulator Ezutromid by Wilkinson, Isabel V. L., Perkins, Kelly J., Dugdale, Hannah, Moir, Lee, Vuorinen, Aini, Chatzopoulou, Maria, Squire, Sarah E., Monecke, Sebastian, Lomow, Alexander, Geese, Marcus, Charles, Philip D., Burch, Peter, Tinsley, Jonathan M., Wynne, Graham M., Davies, Stephen G., Wilson, Francis X., Rastinejad, Fraydoon, Mohammed, Shabaz, Davies, Kay E., Russell, Angela J.

“…Duchenne muscular dystrophy (DMD) is a fatal muscle‐wasting disease arising from mutations in the dystrophin gene. Upregulation of utrophin to compensate for…”
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Second-generation compound for the modulation of utrophin in the therapy of DMD by Guiraud, Simon, Squire, Sarah E, Edwards, Benjamin, Chen, Huijia, Burns, David T, Shah, Nandini, Babbs, Arran, Davies, Stephen G, Wynne, Graham M, Russell, Angela J, Elsey, David, Wilson, Francis X, Tinsley, Jon M, Davies, Kay E

“…Duchenne muscular dystrophy (DMD) is a lethal, X-linked muscle-wasting disease caused by lack of the cytoskeletal protein dystrophin. There is currently no…”
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Anthelmintic drug discovery: target identification, screening methods and the role of open science by Partridge, Frederick A, Forman, Ruth, Bataille, Carole J R, Wynne, Graham M, Nick, Marina, Russell, Angela J, Else, Kathryn J, Sattelle, David B

“…Helminths, including cestodes, nematodes and trematodes, are a huge global health burden, infecting hundreds of millions of people. In many cases, existing…”
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Simvastatin activates single skeletal RyR1 channels but exerts more complex regulation of the cardiac RyR2 isoform by Venturi, Elisa, Lindsay, Chris, Lotteau, Sabine, Yang, Zhaokang, Steer, Emma, Witschas, Katja, Wilson, Abigail D, Wickens, James R, Russell, Angela J, Steele, Derek, Calaghan, Sarah, Sitsapesan, Rebecca

“…Background and Purpose Statins are amongst the most widely prescribed drugs for those at risk of cardiovascular disease, lowering cholesterol levels by…”
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From arylamine N-acetyltransferase to folate-dependent acetyl CoA hydrolase: impact of folic acid on the activity of (HUMAN)NAT1 and its homologue (MOUSE)NAT2 by Laurieri, Nicola, Dairou, Julien, Egleton, James E, Stanley, Lesley A, Russell, Angela J, Dupret, Jean-Marie, Sim, Edith, Rodrigues-Lima, Fernando

“…Acetyl Coenzyme A-dependent N-, O- and N,O-acetylation of aromatic amines and hydrazines by arylamine N-acetyltransferases is well characterised. Here, we…”
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An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes by Partridge, Frederick A., Brown, Anwen E., Buckingham, Steven D., Willis, Nicky J., Wynne, Graham M., Forman, Ruth, Else, Kathryn J., Morrison, Alison A., Matthews, Jacqueline B., Russell, Angela J., Lomas, David A., Sattelle, David B.

“…Parasitic nematodes infect hundreds of millions of people and farmed livestock. Further, plant parasitic nematodes result in major crop damage. The pipeline of…”
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Synthesis of SMT022357 enantiomers and in vivo evaluation in a Duchenne muscular dystrophy mouse model by Babbs, Arran, Berg, Adam, Chatzopoulou, Maria, Davies, Kay E., Davies, Stephen G., Edwards, Benjamin, Elsey, David J., Emer, Enrico, Figuccia, Aude L.A., Fletcher, Ai M., Guiraud, Simon, Harriman, Shawn, Moir, Lee, Robinson, Neil, Rowley, Jessica A., Russell, Angela J., Squire, Sarah E., Thomson, James E., Tinsley, Jonathon M., Wilson, Francis X., Wynne, Graham M.

“…Following on from ezutromid, the first-in-class benzoxazole utrophin modulator that progressed to Phase 2 clinical trials for the treatment of Duchenne…”
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Identification and Preliminary Structure-Activity Relationship Studies of 1,5-Dihydrobenzo[ e ][1,4]oxazepin-2(3 H )-ones That Induce Differentiation of Acute Myeloid Leukemia Cells In Vitro by Josa-Culleré, Laia, Cogswell, Thomas J, Georgiou, Irene, Jay-Smith, Morgan, Jackson, Thomas R, Bataille, Carole J R, Davies, Stephen G, Vyas, Paresh, Milne, Thomas A, Wynne, Graham M, Russell, Angela J

“…Acute myeloid leukemia (AML) is the most aggressive type of blood cancer, and there is a continued need for new treatments that are well tolerated and improve…”
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2,4-Diaminothieno[3,2-d]pyrimidines, a new class of anthelmintic with activity against adult and egg stages of whipworm by Partridge, Frederick A, Forman, Ruth, Willis, Nicky J, Bataille, Carole J R, Murphy, Emma A, Brown, Anwen E, Heyer-Chauhan, Narinder, Marinič, Bruno, Sowood, Daniel J C, Wynne, Graham M, Else, Kathryn J, Russell, Angela J, Sattelle, David B

“…The human whipworm Trichuris trichiura is a parasite that infects around 500 million people globally, with consequences including damage to physical growth and…”
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Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo by Partridge, Frederick A, Murphy, Emma A, Willis, Nicky J, Bataille, Carole J R, Forman, Ruth, Heyer-Chauhan, Narinder, Marinič, Bruno, Sowood, Daniel J C, Wynne, Graham M, Else, Kathryn J, Russell, Angela J, Sattelle, David B

“…Trichuris trichiura is a human parasitic whipworm infecting around 500 million people globally, damaging the physical growth and educational performance of…”
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An Oxidation and Ring Contraction Approach to the Synthesis of (±)-1-Deoxynojirimycin and (±)-1-Deoxyaltronojirimycin by Bagal, Sharan K, Davies, Stephen G, Lee, James A, Roberts, Paul M, Russell, Angela J, Scott, Philip M, Thomson, James E

“…A reaction sequence involving the chemoselective olefinic oxidation of N(1)-benzyl-2,7-dihydro-1H-azepine with m-CPBA in the presence of HBF4 and BnOH followed…”
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