Search Results - "RUSSELL, Aaron P"

The unconditioned fear response in dystrophin-deficient mice is associated with adrenal and vascular function by Lindsay, Angus, Russell, Aaron P.

“…Loss of function mutations in the gene encoding dystrophin elicits a hypersensitive fear response in mice and humans. In the dystrophin-deficient mdx mouse,…”
Get full text

Identification of microRNAs linked to regulators of muscle protein synthesis and regeneration in young and old skeletal muscle by Zacharewicz, Evelyn, Della Gatta, Paul, Reynolds, John, Garnham, Andrew, Crowley, Tamsyn, Russell, Aaron P, Lamon, Séverine

“…Over the course of ageing there is a natural and progressive loss of skeletal muscle mass. The onset and progression of age-related muscle wasting is…”
Get full text

Concurrent exercise incorporating high-intensity interval or continuous training modulates mTORC1 signaling and microRNA expression in human skeletal muscle by Fyfe, Jackson J, Bishop, David J, Zacharewicz, Evelyn, Russell, Aaron P, Stepto, Nigel K

“…We compared the effects of concurrent exercise, incorporating either high-intensity interval training (HIT) or moderate-intensity continuous training (MICT),…”
Get more information

Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis by Russell, Aaron P, Wada, Shogo, Vergani, Lodovica, Hock, M. Benjamin, Lamon, Séverine, Léger, Bertrand, Ushida, Takashi, Cartoni, Romain, Wadley, Glenn D, Hespel, Peter, Kralli, Anastasia, Soraru, Gianni, Angelini, Corrado, Akimoto, Takayuki

“…Abstract Skeletal muscle mitochondrial dysfunction is believed to play a role in the progression and severity of amyotrophic lateral sclerosis (ALS). The…”
Get full text

The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy by Foletta, Victoria C., White, Lloyd J., Larsen, Amy E., Léger, Bertrand, Russell, Aaron P.

“…Skeletal muscle atrophy occurs in many chronic diseases and disuse conditions. Its severity reduces patient recovery, independence and quality of life. The…”
Get full text

Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short‐term endurance training by Russell, Aaron P., Lamon, Severine, Boon, Hanneke, Wada, Shogo, Güller, Isabelle, Brown, Erin L., Chibalin, Alexander V., Zierath, Juleen R., Snow, Rod J., Stepto, Nigel, Wadley, Glenn D., Akimoto, Takayuki

“…Key points •  The discovery of microRNAs (miRNAs) has established new mechanisms that control health, but little is known about the regulation of skeletal…”
Get full text

The CDP-Ethanolamine Pathway Regulates Skeletal Muscle Diacylglycerol Content and Mitochondrial Biogenesis without Altering Insulin Sensitivity by Selathurai, Ahrathy, Kowalski, Greg M., Burch, Micah L., Sepulveda, Patricio, Risis, Steve, Lee-Young, Robert S., Lamon, Severine, Meikle, Peter J., Genders, Amanda J., McGee, Sean L., Watt, Matthew J., Russell, Aaron P., Frank, Matthew, Jackowski, Suzanne, Febbraio, Mark A., Bruce, Clinton R.

“…Accumulation of diacylglycerol (DG) in muscle is thought to cause insulin resistance. DG is a precursor for phospholipids, thus phospholipid synthesis could be…”
Get full text

Molecular regulation of skeletal muscle mass by Russell, Aaron P

“…Summary 1. The maintenance of skeletal muscle mass is determined by a fine balance between protein synthesis and protein degradation. Skeletal mass is…”
Get full text

Increased mitophagy in the skeletal muscle of spinal and bulbar muscular atrophy patients by Borgia, Doriana, Malena, Adriana, Spinazzi, Marco, Desbats, Maria Andrea, Salviati, Leonardo, Russell, Aaron P, Miotto, Giovanni, Tosatto, Laura, Pegoraro, Elena, Sorarù, Gianni, Pennuto, Maria, Vergani, Lodovica

“…Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disorder caused by polyglutamine expansion in the androgen receptor (AR) and characterized by the…”
Get full text

Muscle Adaptations to Heavy-Load and Blood Flow Restriction Resistance Training Methods by May, Anthony K, Russell, Aaron P, Della Gatta, Paul A, Warmington, Stuart A

“…Resistance-based blood flow restriction training (BFRT) improves skeletal muscle strength and size. Unlike heavy-load resistance training (HLRT), there is…”
Get full text

Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes by Dominguez, Eduardo, Galmozzi, Andrea, Chang, Jae Won, Hsu, Ku-Lung, Pawlak, Joanna, Li, Weiwei, Godio, Cristina, Thomas, Jason, Partida, David, Niessen, Sherry, O'Brien, Paul E, Russell, Aaron P, Watt, Matthew J, Nomura, Daniel K, Cravatt, Benjamin F, Saez, Enrique

“…Phenotypic screening for serine hydrolase inhibitors capable of modulating lipid storage coupled with target deconvolution identifies carboxylesterase 3 as…”
Get full text

Regulation of ubiquitin proteasome pathway molecular markers in response to endurance and resistance exercise and training by Stefanetti, Renae J., Lamon, Séverine, Wallace, Marita, Vendelbo, Mikkel H., Russell, Aaron P., Vissing, Kristian

“…Knowledge on the effects of divergent exercise on ostensibly protein degradation pathways may be valuable for counteracting muscle wasting and for…”
Get full text

Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program by Morrison-Nozik, Alexander, Anand, Priti, Zhu, Han, Duan, Qiming, Sabeh, Mohamad, Prosdocimo, Domenick A., Lemieux, Madeleine E., Nordsborg, Nikolai, Russell, Aaron P., MacRae, Calum A., Gerber, Anthony N., Jain, Mukesh K., Haldar, Saptarsi M.

“…Classic physiology studies dating to the 1930s demonstrate that moderate or transient glucocorticoid (GC) exposure improves muscle performance. The ergogenic…”
Get full text

miR-23a suppression accelerates functional decline in the rNLS8 mouse model of TDP-43 proteinopathy by Tsitkanou, Stavroula, Della Gatta, Paul A., Abbott, Gavin, Wallace, Marita A., Lindsay, Angus, Gerlinger-Romero, Frederico, Walker, Adam K., Foletta, Victoria C., Russell, Aaron P.

“…Skeletal muscle dysfunction may contribute to the progression and severity of amyotrophic lateral sclerosis (ALS). In the present study, we characterized the…”
Get full text

An obesogenic maternal environment impairs mouse growth patterns, satellite cell activation, and markers of postnatal myogenesis by Mikovic, Jasmine, Brightwell, Camille, Lindsay, Angus, Wen, Yuan, Kowalski, Greg, Russell, Aaron P, Fry, Christopher S, Lamon, Séverine

“…Skeletal muscle is sensitive to environmental cues that are first present in utero. Maternal overnutrition is a model of impaired muscle development leading to…”
Get more information

Tyk2 and Stat3 Regulate Brown Adipose Tissue Differentiation and Obesity by Derecka, Marta, Gornicka, Agnieszka, Koralov, Sergei B., Szczepanek, Karol, Morgan, Magdalena, Raje, Vidisha, Sisler, Jennifer, Zhang, Qifang, Otero, Dennis, Cichy, Joanna, Rajewsky, Klaus, Shimoda, Kazuya, Poli, Valeria, Strobl, Birgit, Pellegrini, Sandra, Harris, Thurl E., Seale, Patrick, Russell, Aaron P., McAinch, Andrew J., O’Brien, Paul E., Keller, Susanna R., Croniger, Colleen M., Kordula, Tomasz, Larner, Andrew C.

“…Mice lacking the Jak tyrosine kinase member Tyk2 become progressively obese due to aberrant development of Myf5+ brown adipose tissue (BAT). Tyk2 RNA levels in…”
Get full text

Granulocyte colony-stimulating factor receptor: Stimulating granulopoiesis and much more by Liongue, Clifford, Wright, Craig, Russell, Aaron P., Ward, Alister C.

“…The granulocyte colony-stimulating factor receptor (G-CSFR) plays an important role in the production, survival and activation of neutrophilic granulocytes…”
Get full text

Comparative analysis of microRNA expression in mouse and human brown adipose tissue by Güller, Isabelle, McNaughton, Sarah, Crowley, Tamsyn, Gilsanz, Vicente, Kajimura, Shingo, Watt, Matthew, Russell, Aaron P

“…In small mammals brown adipose tissue (BAT) plays a predominant role in regulating energy expenditure (EE) via adaptive thermogenesis. New-born babies require…”
Get full text

Loss of skeletal muscle estrogen-related receptors leads to severe exercise intolerance by Wattez, Jean-Sébastien, Eury, Elodie, Hazen, Bethany C., Wade, Alexa, Chau, Sarah, Ou, Shu-Ching, Russell, Aaron P., Cho, Yoshitake, Kralli, Anastasia

“…Skeletal muscle oxidative capacity is central to physical activity, exercise capacity and whole-body metabolism. The three estrogen-related receptors (ERRs)…”
Get full text

Granulocyte Colony-Stimulating Factor and Its Potential Application for Skeletal Muscle Repair and Regeneration by Wright, Craig Robert, Russell, Aaron P., Ward, Alister C.

“…Granulocyte colony-stimulating factor (G-CSF) was originally discovered in the context of hematopoiesis. However, the identification of the G-CSF receptor…”
Get full text