Search Results - "RUSNAK, Frank"

Calcineurin: Form and Function by Rusnak, Frank, Mertz, Pamela

“…Section of Hematology Research and Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota; and Department of Chemistry and…”
Get full text

Nitric Oxide Generated from Isoniazid Activation by KatG: Source of Nitric Oxide and Activity against Mycobacterium tuberculosis by TIMMINS, Graham S, MASTER, Sharon, RUSNAK, Frank, DERETIC, Vojo

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Correlation between Isoniazid Resistance and Superoxide Reactivity in Mycobacterium tuberculosis KatG by Ghiladi, Reza A, Medzihradszky, Katalin F, Rusnak, Frank M, Ortiz de Montellano, Paul R

“…Isoniazid is an antituberculosis prodrug that requires activation by the catalase-peroxidase (KatG) of Mycobacterium tuberculosis. The activated species,…”
Get full text

What is the ultimate fate of superoxide anion in vivo? by Auchère, Françoise, Rusnak, Frank

“…For three decades, oxidative stress and the role of reactive oxygen species in biology have been extensively studied. Recently, a new interest in these areas…”
Get full text

Inhibition of Calcineurin Phosphatase Activity by a Calcineurin B Homologous Protein by Lin, X, Sikkink, R A, Rusnak, F, Barber, D L

“…Calcineurin, a Ca 2+ /calmodulin-stimulated protein phosphatase, plays a key role in T-cell activation by regulating the activity of NFAT ( n uclear f actor of…”
Get full text

Requirements for Nitric Oxide Generation from Isoniazid Activation In Vitro and Inhibition of Mycobacterial Respiration In Vivo by TIMMINS, Graham S, MASTER, Sharon, RUSNAK, Frank, DERETIC, Vojo

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Failure of Calcineurin Inhibitors to Prevent Pressure-Overload Left Ventricular Hypertrophy in Rats by Zhang, Weiguo, Kowal, Robert C, Rusnak, Frank, Sikkink, Robert A, Olson, Eric N, Victor, Ronald G

“…A rapidly emerging body of literature implicates a pivotal role for the Ca phosphatase calcineurin as a cellular target for a variety of Ca signaling pathways…”
Get full text

The Treponema pallidum tro Operon Encodes a Multiple Metal Transporter, a Zinc-dependent Transcriptional Repressor, and a Semi-autonomously Expressed Phosphoglycerate Mutase by Hazlett, Karsten R.O., Rusnak, Frank, Kehres, David G., Bearden, Scott W., La Vake, Carson J., La Vake, Morgan E., Maguire, Michael E., Perry, Robert D., Radolf, Justin D.

“…The Treponema pallidum tro operon encodes an ABC transporter (TroABCD), a transcriptional repressor (TroR), and the essential glycolytic enzyme…”
Get full text

Neelaredoxin, an Iron-binding Protein from the Syphilis Spirochete, Treponema pallidum, Is a Superoxide Reductase by Jovanović, T, Ascenso, C, Hazlett, K R, Sikkink, R, Krebs, C, Litwiller, R, Benson, L M, Moura, I, Moura, J J, Radolf, J D, Huynh, B H, Naylor, S, Rusnak, F

“…Treponema pallidum , the causative agent of venereal syphilis, is a microaerophilic obligate pathogen of humans. As it disseminates hematogenously and invades…”
Get full text

Gene sequence and crystal structure of the aldehyde oxidoreductase from Desulfovibrio desulfuricans ATCC 27774 by Rebelo, Jorge, Macieira, Sofia, Dias, João M., Huber, Robert, Ascenso, Carla S., Rusnak, Frank, Moura, José J.G., Moura, Isabel, Romão, Maria J.

“…The aldehyde oxidoreductase (MOD) isolated from the sulfate reducer Desulfovibrio desulfuricans (ATCC 27774) is a member of the xanthine oxidase family of…”
Get full text

Oxidative Stress Increases Susceptibility of Mycobacterium tuberculosis to Isoniazid by BULATOVIC, Vanja M, WENGENACK, Nancy L, UHF, James R, HALL, Leslie, ROBERTS, Glenn D, COCKERILL, Franklin R, RUSNAK, Frank

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Asymmetric retraction of growth cone filopodia following focal inactivation of calcineurin by Chang, Howard Y, Takei, Kohtaro, Sydor, Anne M, Born, Timothy, Rusnak, Frank, Jay, Daniel G

“…The neuronal growth cone is thought to be the site of decision making in nerve growth and guidance. One likely mechanism of how the growth cone translates…”
Get full text

Spectroscopic and Enzymatic Characterization of the Active Site Dinuclear Metal Center of Calcineurin:  Implications for a Mechanistic Role by Yu, Lian, Golbeck, John, Yao, Janet, Rusnak, Frank

“…The active site of bovine brain calcineurin contains an Fe3+−Zn2+ dinuclear metal center. Replacement of Zn2+ with Fe2+ yields a mixed valence Fe3+−Fe2+ center…”
Get full text

Contributions of Myristoylation to Calcineurin Structure/Function by Kennedy, M T, Brockman, H, Rusnak, F

“…Calcineurin is a serine/threonine protein phosphatase composed of a catalytic subunit, calcineurin A (58 kDa), and a NH 2 -terminal myristoylated regulatory…”
Get full text

Thrombin induced inhibition of neurite outgrowth from dorsal root ganglion neurons by Gill, Jagjit S, Pitts, Kelly, Rusnak, Frank M, Owen, Whyte G, Windebank, Anthony J

“…Thrombin is a multifunctional protease. Recent studies on cultured neuronal cells have suggested a function for thrombin in the development and maintenance of…”
Get full text

Differential Regulation of Growth and Checkpoint Control Mediated by a Cdc25 Mitotic Phosphatase from Pneumocystis carinii by Gustafson, Michael P., Thomas, Charles F., Rusnak, Frank, Limper, Andrew H., Leof, Edward B.

“…Pneumocystis carinii is an opportunistic fungal pathogen phylogenetically related to the fission yeast Schizosaccharomyces pombe. P. carinii causes severe…”
Get full text

Spectroscopic Comparison of the Heme Active Sites in WT KatG and Its S315T Mutant by Lukat-Rodgers, Gudrun S, Wengenack, Nancy L, Rusnak, Frank, Rodgers, Kenton R

“…KatG, the catalase-peroxidase from Mycobacterium tuberculosis, has been characterized by resonance Raman, electron spin resonance, and visible spectroscopies…”
Get full text

Carbon Monoxide Adducts of KatG and KatG(S315T) as Probes of the Heme Site and Isoniazid Binding by Lukat-Rodgers, Gudrun S, Wengenack, Nancy L, Rusnak, Frank, Rodgers, Kenton R

“…KatG, the catalase peroxidase from Mycobacterium tuberculosis, is important in the activation of the antitubercular drug, isoniazid. About 50% of…”
Get full text

Characterization of the calcium-binding sites of calcineurin B by Kakalis, Lazaros T, Kennedy, Michael, Sikkink, Robert, Rusnak, Frank, Armitage, Ian M

“…Calcineurin (CaN) is a calcium- and calmodulin-dependent serine/threonine phosphatase whose inhibition by the immunosuppressant-immunophilin complexes…”
Get full text

Subcloning, expression, and purification of the enterobactin biosynthetic enzyme 2,3-dihydroxybenzoate-AMP ligase: demonstration of enzyme-bound (2,3-dihydroxybenzoyl)adenylate product by Rusnak, Frank, Faraci, W. Stephen, Walsh, Christopher T

“…The gene coding for the enzyme 2,3-dihydroxybenzoate-AMP ligase (2,3DHB-AMP ligase), responsible for activating 2,3-dihydroxybenzoic acid in the biosynthesis…”
Get full text