Search Results - "RUS, Horea"

RGC-32 mediates proinflammatory and profibrotic pathways in immune-mediated kidney disease by Tatomir, Alexandru, Vlaicu, Sonia, Nguyen, Vinh, Luzina, Irina G., Atamas, Sergei P., Drachenberg, Cinthia, Papadimitriou, John, Badea, Tudor C., Rus, Horea G., Rus, Violeta

“…Systemic lupus erythematosus is an autoimmune disease that results in immune-mediated damage to kidneys and other organs. We investigated the role of response…”
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Membrane attack by complement: the assembly and biology of terminal complement complexes by Tegla, Cosmin A., Cudrici, Cornelia, Patel, Snehal, Trippe, Richard, Rus, Violeta, Niculescu, Florin, Rus, Horea

“…Complement system activation plays an important role in both innate and acquired immunity. Activation of the complement and the subsequent formation of C5b-9…”
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CTL-Promoting Effects of IL-21 Counteract Murine Lupus in the Parent→F1 Graft-versus-Host Disease Model by Nguyen, Vinh, Rus, Horea, Chen, Ching, Rus, Violeta

“…IL-21 promotes B cell and CTL responses in vivo, conferring IL-21 with a role in both humoral and cellular responses. Because CTL can target and eliminate…”
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Multiple sclerosis disease activity, a multi-biomarker score of disease activity and response to treatment in multiple sclerosis by Tatomir, Alexandru, Anselmo, Freidrich, Boodhoo, Dallas, Chen, Hegang, Mekala, Armugam P, Nguyen, Vinh, Cuevas, Jacob, Rus, Violeta, Rus, Horea

“…Regular assessment of disease activity in relapsing-remitting multiple sclerosis (RRMS) is required to optimize clinical outcomes. Biomarkers can be a valuable…”
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COVID, complement, and the brain by Vlaicu, Sonia I, Tatomir, Alexandru, Cuevas, Jacob, Rus, Violeta, Rus, Horea

“…The brains of COVID-19 patients are affected by the SARS-CoV-2 virus, and these effects may contribute to several COVID-19 sequelae, including cognitive…”
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Role of C5b-9 and RGC-32 in Cancer by Vlaicu, Sonia I, Tatomir, Alexandru, Rus, Violeta, Rus, Horea

“…The complement system represents an effective arsenal of innate immunity as well as an interface between innate and adaptive immunity. Activation of the…”
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The liver and muscle secreted HFE2-protein maintains central nervous system blood vessel integrity by Wang, Xue Fan, Vigouroux, Robin, Syonov, Michal, Baglaenko, Yuriy, Nikolakopoulou, Angeliki M., Ringuette, Dene, Rus, Horea, DiStefano, Peter V., Dufour, Suzie, Shabanzadeh, Alireza P., Lee, Seunggi, Mueller, Bernhard K., Charish, Jason, Harada, Hidekiyo, Fish, Jason E., Wither, Joan, Wälchli, Thomas, Cloutier, Jean-François, Zlokovic, Berislav V., Carlen, Peter L., Monnier, Philippe P.

“…Liver failure causes breakdown of the Blood CNS Barrier (BCB) leading to damages of the Central-Nervous-System (CNS), however the mechanisms whereby the liver…”
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Early versus delayed treatment with glatiramer acetate: Analysis of up to 27 years of continuous follow-up in a US open-label extension study by Ford, Corey C, Cohen, Jeffrey A, Goodman, Andrew D, Lindsey, John W, Lisak, Robert P, Luzzio, Christopher, Pruitt, Amy, Rose, John, Rus, Horea, Wolinsky, Jerry S, Kadosh, Shaul E, Bernstein-Hanlon, Emily, Stark, Yafit, Alexander, Jessica K

“…Background: Glatiramer acetate (GA) is US-approved for relapsing multiple sclerosis. Objectives: To describe GA long-term clinical profile. To compare…”
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1005 Response gene to complement-32 facilitates local recruitment of Th1 and Th17 cells and promotes renal inflammation in immune complex mediated glomerulonephritis by Nguyen, Vinh, Tatomir, Alexandru, Papadimitriou, John, Drachenberg, Cinthia, Badea, Tudor, Rus, Horea, Rus, Violeta

“…BackgroundResponse Gene to Complement (RGC)-32 is a cell cycle regulator induced by complement activation, growth factors and cytokines. RGC-32 mediates TGF-β…”
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Histone Deacetylase SIRT1 Mediates C5b-9-Induced Cell Cycle in Oligodendrocytes by Tatomir, Alexandru, Rao, Gautam, Boodhoo, Dallas, Vlaicu, Sonia I, Beltrand, Austin, Anselmo, Freidrich, Rus, Violeta, Rus, Horea

“…Sublytic levels of C5b-9 increase the survival of oligodendrocytes (OLGs) and induce the cell cycle. We have previously observed that SIRT1 co-localizes with…”
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1105 Response Gene to Complement-32 expression is upregulated in the kidney and promotes renal fibrosis in lupus nephritis by Nguyen, Vinh, Tatomir, Alex, Drachenberg, Cinthia, Rus, Horea, Rus, Violeta

“…BackgroundRGC (Response Gene to Complement)-32 is a cell cycle regulator widely expressed in normal tissues, multiple tumors and in a variety of cell lines…”
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Role of RGC-32 in multiple sclerosis and neuroinflammation – few answers and many questions by Tatomir, Alexandru, Cuevas, Jacob, Badea, Tudor C., Muresanu, Dafin F., Rus, Violeta, Rus, Horea

“…Recent advances in understanding the pathogenesis of multiple sclerosis (MS) have brought into the spotlight the major role played by reactive astrocytes in…”
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RGC-32 Promotes Th17 Cell Differentiation and Enhances Experimental Autoimmune Encephalomyelitis by Rus, Violeta, Nguyen, Vinh, Tatomir, Alexandru, Lees, Jason R, Mekala, Armugam P, Boodhoo, Dallas, Tegla, Cosmin A, Luzina, Irina G, Antony, Paul A, Cudrici, Cornelia D, Badea, Tudor C, Rus, Horea G

“…Th17 cells play a critical role in autoimmune diseases, including multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Response…”
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The role of the complement system in innate immunity by Rus, Horea, Cudrici, Cornelia, Niculescu, Florin

“…Complement is a major component of innate immune system involved in defending against all the foreign pathogens through complement fragments that participate…”
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RGC-32 Regulates Generation of Reactive Astrocytes in Experimental Autoimmune Encephalomyelitis by Tatomir, Alexandru, Beltrand, Austin, Nguyen, Vinh, Boodhoo, Dallas, Mekala, Armugam, Cudrici, Cornelia, Badea, Tudor C, Muresanu, Dafin F, Rus, Violeta, Rus, Horea

“…Astrocytes are increasingly recognized as critical contributors to multiple sclerosis pathogenesis. We have previously shown that lack of Response Gene to…”
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RGC-32 Acts as a Hub to Regulate the Transcriptomic Changes Associated With Astrocyte Development and Reactive Astrocytosis by Tatomir, Alexandru, Beltrand, Austin, Nguyen, Vinh, Courneya, Jean-Paul, Boodhoo, Dallas, Cudrici, Cornelia, Muresanu, Dafin F, Rus, Violeta, Badea, Tudor C, Rus, Horea

“…Response Gene to Complement 32 (RGC-32) is an important mediator of the TGF-β signaling pathway, and an increasing amount of evidence implicates this protein…”
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RGC-32 regulates reactive astrocytosis and extracellular matrix deposition in experimental autoimmune encephalomyelitis by Tatomir, Alexandru, Tegla, Cosmin A., Martin, Alvaro, Boodhoo, Dallas, Nguyen, Vinh, Sugarman, Adam J., Mekala, Armugam, Anselmo, Freidrich, Talpos-Caia, Anamaria, Cudrici, Cornelia, Badea, Tudor C., Rus, Violeta, Rus, Horea

“…Extracellular matrix (ECM) deposition in active demyelinating multiple sclerosis (MS) lesions may impede axonal regeneration and can modify immune reactions…”
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Targeting Repulsive Guidance Molecule A to Promote Regeneration and Neuroprotection in Multiple Sclerosis by Demicheva, Elena, Cui, Yi-Fang, Bardwell, Philip, Barghorn, Stefan, Kron, Martina, Meyer, Axel H., Schmidt, Martin, Gerlach, Björn, Leddy, Mary, Barlow, Eve, O’Connor, Elizabeth, Choi, Chee-Ho, Huang, Lili, Veldman, Geertruida M., Rus, Horea, Shabanzadeh, Alireza P., Tassew, Nardos G., Monnier, Philippe P., Müller, Thomas, Calabresi, Peter A., Schoemaker, Hans, Mueller, Bernhard K.

“…Repulsive guidance molecule A (RGMa) is a potent inhibitor of neuronal regeneration and a regulator of cell death, and it plays a role in multiple sclerosis…”
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The role of complement system in adipose tissue-related inflammation by Vlaicu, Sonia I., Tatomir, Alexandru, Boodhoo, Dallas, Vesa, Stefan, Mircea, Petru A., Rus, Horea

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C5b-9-induced Endothelial Cell Proliferation and Migration Are Dependent on Akt Inactivation of Forkhead Transcription Factor FOXO1 by Fosbrink, Matthew, Niculescu, Florin, Rus, Violeta, Shin, Moon L., Rus, Horea

“…Migration and proliferation of aortic endothelial cells (AEC) are critical processes involved in angiogenesis, atherosclerosis, and postangioplasty restenosis…”
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