Search Results - "RUPP, Christian"

Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma by Zhang, Qianfei, Ma, Chi, Duan, Yi, Heinrich, Bernd, Rosato, Umberto, Diggs, Laurence P, Ma, Lichun, Roy, Soumen, Fu, Qiong, Brown, Zachary J, Wabitsch, Simon, Thovarai, Vishal, Fu, Jianyang, Feng, Dechun, Ruf, Benjamin, Cui, Linda L, Subramanyam, Varun, Frank, Karen M, Wang, Sophie, Kleiner, David E, Ritz, Thomas, Rupp, Christian, Gao, Bin, Longerich, Thomas, Kroemer, Alexander, Wang, Xin Wei, Ruchirawat, Mathuros, Korangy, Firouzeh, Schnabl, Bernd, Trinchieri, Giorgio, Greten, Tim F

“…Gut dysbiosis is commonly observed in patients with cirrhosis and chronic gastrointestinal disorders; however, its effect on antitumor immunity in the liver is…”
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Body Fluid Exosomes Promote Secretion of Inflammatory Cytokines in Monocytic Cells via Toll-like Receptor Signaling by Bretz, Niko P., Ridinger, Johannes, Rupp, Anne-Kathleen, Rimbach, Katharina, Keller, Sascha, Rupp, Christian, Marmé, Frederik, Umansky, Ludmila, Umansky, Viktor, Eigenbrod, Tatjana, Sammar, Marei, Altevogt, Peter

“…Tumor-derived exosomes have been shown to induce various immunomodulatory effects. However, the underlying signaling pathways are poorly understood. Here, we…”
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Mismatch repair deficiency is a rare but putative therapeutically relevant finding in non-liver fluke associated cholangiocarcinoma by Goeppert, Benjamin, Roessler, Stephanie, Renner, Marcus, Singer, Stephan, Mehrabi, Arianeb, Vogel, Monika Nadja, Pathil, Anita, Czink, Elena, Köhler, Bruno, Springfeld, Christoph, Pfeiffenberger, Jan, Rupp, Christian, Weiss, Karl Heinz, Schirmacher, Peter, von Knebel Doeberitz, Magnus, Kloor, Matthias

“…Background A major molecular pathway of genetic instability in cancer is DNA mismatch repair deficiency. High-level microsatellite instability (MSI-H) is…”
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Diagnostic and prognostic biomarkers in cholangiocarcinoma by Macias, Rocio I. R., Kornek, Miroslaw, Rodrigues, Pedro M., Paiva, Nuno A., Castro, Rui E., Urban, Sabine, Pereira, Stephen P., Cadamuro, Massimiliano, Rupp, Christian, Loosen, Sven H., Luedde, Tom, Banales, Jesus M.

“…The high mortality rate of cholangiocarcinoma (CCA) is due, in part, to the lack of non‐invasive approaches able to accurately detect this silent tumour at…”
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A randomized waitlist-controlled trial comparing detached mindfulness and cognitive restructuring in obsessive-compulsive disorder by Rupp, Christian, Jürgens, Charlotte, Doebler, Philipp, Andor, Fabian, Buhlmann, Ulrike

“…Whereas research has demonstrated the efficacy of cognitive restructuring (CR) for obsessive-compulsive disorder (OCD), little is known about the efficacy of…”
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Loss of EpCAM expression in breast cancer derived serum exosomes: Role of proteolytic cleavage by Rupp, Anne-Kathleen, Rupp, Christian, Keller, Sascha, Brase, Jan C, Ehehalt, Robert, Fogel, Mina, Moldenhauer, Gerhard, Marmé, Frederik, Sültmann, Holger, Altevogt, Peter

“…Abstract Objective Cancer cells in the body release soluble and membranous factors that manipulate the tumor environment to facilitate growth and survival…”
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Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1 by Kauko, Otto, Imanishi, Susumu Y., Kulesskiy, Evgeny, Yetukuri, Laxman, Laajala, Teemu Daniel, Sharma, Mukund, Pavic, Karolina, Aakula, Anna, Rupp, Christian, Jumppanen, Mikael, Haapaniemi, Pekka, Ruan, Luyao, Yadav, Bhagwan, Suni, Veronika, Varila, Taru, Corthals, Garry L., Reimand, Jüri, Wennerberg, Krister, Aittokallio, Tero, Westermarck, Jukka

“…Protein phosphatase 2A (PP2A) critically regulates cell signaling and is a human tumor suppressor. PP2A complexes are modulated by proteins such as cancerous…”
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Biliary strictures and recurrence after liver transplantation for primary sclerosing cholangitis: A retrospective multicenter analysis by Hildebrand, Tatiana, Pannicke, Nadine, Dechene, Alexander, Gotthardt, Daniel N., Kirchner, Gabriele, Reiter, Florian P., Sterneck, Martina, Herzer, Kerstin, Lenzen, Henrike, Rupp, Christian, Barg‐Hock, Hannelore, Leuw, Philipp, Teufel, Andreas, Zimmer, Vincent, Lammert, Frank, Sarrazin, Christoph, Spengler, Ulrich, Rust, Christian, Manns, Michael P., Strassburg, Christian P., Schramm, Christoph, Weismüller, Tobias J.

“…Liver transplantation (LT) is the only definitive treatment for patients with end‐stage liver disease due to primary sclerosing cholangitis (PSC), but a high…”
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Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness by Wan, Shan, Meyer, Anne‐Sophie, Weiler, Sofia Maria Elisabeth, Rupp, Christian, Tóth, Marcell, Sticht, Carsten, Singer, Stephan, Thomann, Stefan, Roessler, Stephanie, Schorpp‐Kistner, Marina, Schmitt, Jennifer, Gretz, Norbert, Angel, Peter, Tschaharganeh, Darjus Felix, Marquardt, Jens, Schirmacher, Peter, Pinna, Federico, Breuhahn, Kai

“…The loss of epithelial cell polarity plays an important role in the development and progression of liver cancer. However, the specific molecular mechanisms…”
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EGFR-ras-raf signaling in epidermal stem cells: roles in hair follicle development, regeneration, tissue remodeling and epidermal cancers by Doma, Eszter, Rupp, Christian, Baccarini, Manuela

“…The mammalian skin is the largest organ of the body and its outermost layer, the epidermis, undergoes dynamic lifetime renewal through the activity of somatic…”
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Pregnancy with inflammatory bowel disease: Outcomes for mothers and their children at a European tertiary care center by Hoffmann, Peter, Krueger, Julian, Bashlekova, Teodora, Rupp, Christian, Baumann, Lukas, Gauss, Annika

“…Aim The study aimed at investigating pregnancy complications, birth outcomes, and postnatal child development in pregnancies of women with inflammatory bowel…”
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miRNA profiling of biliary intraepithelial neoplasia reveals stepwise tumorigenesis in distal cholangiocarcinoma via the miR‐451a/ATF2 axis by Loeffler, Moritz A, Hu, Jun, Kirchner, Martina, Wei, Xiyang, Xiao, Yi, Albrecht, Thomas, De La Torre, Carolina, Sticht, Carsten, Banales, Jesus M, Vogel, Monika N, Pathil‐Warth, Anita, Mehrabi, Arianeb, Hoffmann, Katrin, Rupp, Christian, Köhler, Bruno, Springfeld, Christoph, Schirmacher, Peter, Ji, Junfang, Roessler, Stephanie, Goeppert, Benjamin

“…Distal cholangiocarcinoma (dCCA) is a biliary tract cancer with a dismal prognosis and is often preceded by biliary intraepithelial neoplasia (BilIN),…”
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Programmed cell death ligand 1 (PD-L1, CD274) in cholangiocarcinoma - correlation with clinicopathological data and comparison of antibodies by Kriegsmann, Mark, Roessler, Stephanie, Kriegsmann, Katharina, Renner, Marcus, Longuespée, Rémi, Albrecht, Thomas, Loeffler, Moritz, Singer, Stephan, Mehrabi, Arianeb, Vogel, Monika Nadja, Pathil, Anita, Köhler, Bruno, Springfeld, Christoph, Rupp, Christian, Weiss, Karl Heinz, Goeppert, Benjamin

“…Cholangiocarcinoma (CCA) may arise in the intra- or extrahepatic biliary tract and is associated with a poor prognosis. Despite recent advances, to date there…”
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Statin use is associated with the reduction in hepatocellular carcinoma recurrence after liver surgery by Khajeh, Elias, Moghadam, Arash Dooghaie, Eslami, Pegah, Ali-Hasan-Al-Saegh, Sadeq, Ramouz, Ali, Shafiei, Saeed, Ghamarnejad, Omid, Dezfouli, Sepehr Abbasi, Rupp, Christian, Springfeld, Christoph, Carvalho, Carlos, Probst, Pascal, Mousavizadeh, Seyed Mostafa, Mehrabi, Arianeb

“…Hepatocellular carcinoma (HCC) is the sixth most common form of cancer worldwide. Although surgical treatments have an acceptable cure rate, tumor recurrence…”
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HER2 gene (ERBB2) amplification is a rare event in non-liver-fluke associated cholangiocarcinogenesis by Albrecht, Thomas, Rausch, Melina, Rössler, Stephanie, Albrecht, Michael, Braun, Jana Dorothea, Geissler, Veronika, Mehrabi, Arianeb, Vogel, Monika Nadja, Pathil-Warth, Anita, Mechtersheimer, Gunhild, Renner, Marcus, Rupp, Christian, Weiss, Karl Heinz, Busch, Elena, Köhler, Bruno, Springfeld, Christoph, Schirmacher, Peter, Goeppert, Benjamin

“…Cholangiocarcinoma is a rapidly fatal cancer entity with a median survival of less than one year. In contrast to many other malignancies, no substantial…”
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PP2A methylesterase PME‐1 suppresses anoikis and is associated with therapy relapse of PTEN‐deficient prostate cancers by Aakula, Anna, Isomursu, Aleksi, Rupp, Christian, Erickson, Andrew, Gupta, Nikhil, Kauko, Otto, Shah, Pragya, Padzik, Artur, Pokharel, Yuba Raj, Kaur, Amanpreet, Li, Song‐Ping, Trotman, Lloyd, Taimen, Pekka, Rannikko, Antti, Lammerding, Jan, Paatero, Ilkka, Mirtti, Tuomas, Ivaska, Johanna, Westermarck, Jukka

“…While organ‐confined prostate cancer (PCa) is mostly therapeutically manageable, metastatic progression of PCa remains an unmet clinical challenge. Resistance…”
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Prevalence of human herpesviruses in biliary fluid and their association with biliary complications after liver transplantation by Rauber, Conrad, Bartelheimer, Katja, Zhou, Taotao, Rupp, Christian, Schnitzler, Paul, Schemmer, Peter, Sauer, Peter, Weiss, Karl Heinz, Gotthardt, Daniel Nils

“…Beta-herpesviruses are common opportunistic pathogens that cause morbidity after liver transplantation (LT). Objective of the study was to evaluate the…”
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Feasibility, effectiveness, and safety of endoscopic vacuum therapy for intrathoracic anastomotic leakage following transthoracic esophageal resection by Zhang, Chengcheng Christine, Liesenfeld, Lukas, Klotz, Rosa, Koschny, Ronald, Rupp, Christian, Schmidt, Thomas, Diener, Markus K, Müller-Stich, Beat P, Hackert, Thilo, Sauer, Peter, Büchler, Markus W, Schaible, Anja

“…Anastomotic leakage (AL) in the upper gastrointestinal (GI) tract is associated with high morbidity and mortality rates. Especially intrathoracic anastomotic…”
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Clinical features and surgical outcomes of fibrolamellar hepatocellular carcinoma: retrospective analysis of a single-center experience by Lemekhova, Anastasia, Hornuss, Daniel, Polychronidis, Georgios, Mayer, Philipp, Rupp, Christian, Longerich, Thomas, Weiss, Karl-Heinz, Büchler, Markus, Mehrabi, Arianeb, Hoffmann, Katrin

“…Clinicopathological features and surgical outcomes of patients with fibrolamellar hepatocellular carcinoma (FL-HCC) are underreported. The aim of this study is…”
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Transcriptomic Cross‐Species Analysis of Chronic Liver Disease Reveals Consistent Regulation Between Humans and Mice by Holland, Christian H., Ramirez Flores, Ricardo O., Myllys, Maiju, Hassan, Reham, Edlund, Karolina, Hofmann, Ute, Marchan, Rosemarie, Cadenas, Cristina, Reinders, Jörg, Hoehme, Stefan, Seddek, Abdel‐latif, Dooley, Steven, Keitel, Verena, Godoy, Patricio, Begher‐Tibbe, Brigitte, Trautwein, Christian, Rupp, Christian, Mueller, Sebastian, Longerich, Thomas, Hengstler, Jan G., Saez‐Rodriguez, Julio, Ghallab, Ahmed

“…Mouse models are frequently used to study chronic liver diseases (CLDs). To assess their translational relevance, we quantified the similarity of commonly used…”
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