Search Results - "RUNKUAN YANG"

HMGB1 and Extracellular Histones Significantly Contribute to Systemic Inflammation and Multiple Organ Failure in Acute Liver Failure by Tonnessen, Tor Inge, Tenhunen, Jyrki, Zou, Xiaoping, Yang, Runkuan

“…Acute liver failure (ALF) is the culmination of severe liver cell injury from a variety of causes. ALF occurs when the extent of hepatocyte death exceeds the…”
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HMGB1 and Histones Play a Significant Role in Inducing Systemic Inflammation and Multiple Organ Dysfunctions in Severe Acute Pancreatitis by Yang, Runkuan, Tonnessen, Tor Inge, Tenhunen, Jyrki

“…Severe acute pancreatitis (SAP) starts as a local inflammation of pancreatic tissue that induces the development of multiple extrapancreatic organs…”
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Bile and circulating HMGB1 contributes to systemic inflammation in obstructive jaundice by Yang, Runkuan, Zhu, Shengtao, Pischke, Soeren Erik, Haugaa, Hakon, Zou, Xiaoping, Tonnessen, Tor Inge

“…Obstructive jaundice (OJ) patients with cholangitis are prone to sepsis; however, the underlying mechanisms are still not clear and need to be clarified…”
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Serum Uric Acid Is a Mediator of the Association Between Obesity and Incident Nonalcoholic Fatty Liver Disease: A Prospective Cohort Study by Zhang, Qian, Ma, Xiaoqian, Xing, Jie, Shi, Haiyun, Yang, Runkuan, Jiao, Yue, Chen, Shuohua, Wu, Shouling, Zhang, Shutian, Sun, Xiujing

“…Obesity has been demonstrated to show a consistent link with the increased possibility of nonalcoholic fatty liver disease (NAFLD). Since both serum uric acid…”
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Ethyl pyruvate supplemented in drinking water ameliorates experimental nonalcoholic steatohepatitis by Sun, Xiujing, Zhu, Shengtao, Dong, Xueyu, Strand-Amundsen, Runar J., Tonnessen, Tor Inge, Yang, Runkuan

“…Inflammation and oxidative stress play a significant role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Ethyl pyruvate (EP) is a novel…”
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High mobility group B1 impairs hepatocyte regeneration in acetaminophen hepatotoxicity by Yang, Runkuan, Zhang, Shutian, Cotoia, Antonella, Oksala, Niku, Zhu, Shengtao, Tenhunen, Jyrki

“…Acetaminophen (APAP) overdose induces massive hepatocyte necrosis. Necrotic tissue releases high mobility group B1 (HMGB1), and HMGB1 contributes to liver…”
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Ethyl Pyruvate Prevents Lethality in Mice with Established Lethal Sepsis and Systemic Inflammation by Ulloa, Luis, Ochani, Mahendar, Yang, Huan, Tanovic, Mahira, Halperin, Daniel, Yang, Runkuan, Czura, Christopher J., Fink, Mitchell P., Tracey, Kevin J.

“…Sepsis, a potentially fatal clinical syndrome, is mediated by an early (e.g., tumor necrosis factor and IL-1) and late [e.g., high mobility group B-1 (HMGB1)]…”
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HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice by Sappington, Penny L., Yang, Runkuan, Yang, Huan, Tracey, Kevin J., Delude, Russell L., Fink, Mitchell P.

“…Background & Aims: High mobility group (HMG) B1 is a nonhistone nuclear protein that was recently identified as a late-acting mediator of…”
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Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock by Yang, Runkuan, Harada, Tomoyuki, Mollen, Kevin P, Prince, Jose M, Levy, Ryan M, Englert, Joshua A, Gallowitsch-Puerta, Margot, Yang, LiHong, Yang, Huan, Tracey, Kevin J, Harbrecht, Brian G, Billiar, Timothy R, Fink, Mitchell P

“…Intestinal barrier dysfunction occurs following hemorrhagic shock and resuscitation (HS/R). High-mobility group B1 (HMGB1) has been shown to increase the…”
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Ethyl Pyruvate Ameliorates Liver Injury Secondary to Severe Acute Pancreatitis by Yang, Runkuan, M.D., Ph.D, Shaufl, Angel L, Killeen, Meaghan E, Fink, Mitchell P., M.D

“…Background Ethyl pyruvate (EP) is capable of significantly decreasing serum alanine aminotransferase and reducing hepatic necrosis in a murine model of severe…”
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Toll-Like Receptor-4 Signaling Mediates Hepatic Injury and Systemic Inflammation in Hemorrhagic Shock by Prince, Jose M., Levy, Ryan M., Yang, Runkuan, Mollen, Kevin P., Fink, Mitchell P., Vodovotz, Yoram, Billiar, Timothy R.

“…Hemorrhagic shock and resuscitation (HS/R) activates inflammatory pathways leading to organ injury after trauma. Toll-like receptors (TLRs), such as TLR4, are…”
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Increased iNOS activity is essential for intestinal epithelial tight junction dysfunction in endotoxemic mice by XIAONAN HAN, FINK, Mitchell P, RUNKUAN YANG, DELUDE, Russell L

“…We tested the hypothesis that increased production of nitric oxide (NO.) associated with lipopolysaccharide (LPS)-induced systemic inflammation leads to…”
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Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4 by Levy, Ryan M, Prince, Jose M, Yang, Runkuan, Mollen, Kevin P, Liao, Hong, Watson, Gregory A, Fink, Mitchell P, Vodovotz, Yoram, Billiar, Timothy R

“…Extensive soft tissue injury and bone fracture are significant contributors to the initial systemic inflammatory response in multiply injured patients…”
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IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice by Yang, Runkuan, Han, Xiaonan, Uchiyama, Takashi, Watkins, Simon K, Yaguchi, Arino, Delude, Russell L, Fink, Mitchell P

“…We sought to determine the role of IL-6 as a mediator of the alterations in gut barrier function that occur after hemorrhagic shock and resuscitation (HS/R)…”
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Structural basis for the proinflammatory cytokine activity of high mobility group box 1 by Li, Jianhua, Kokkola, Riikka, Tabibzadeh, Siamak, Yang, Runkuan, Ochani, Mahendar, Qiang, Xiaoling, Harris, Helena E, Czura, Christopher J, Wang, Haichao, Ulloa, Luis, Wang, Hong, Warren, H Shaw, Moldawer, Lyle L, Fink, Mitchell P, Andersson, Ulf, Tracey, Kevin J, Yang, Huan

“…High mobility group box 1 (HMGB), a ubiquitous DNA-binding protein, has been implicated as a proinflammatory cytokine and late mediator of lethal endotoxemia…”
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Bile high-mobility group box 1 contributes to gut barrier dysfunction in experimental endotoxemia by Yang, Runkuan, Miki, Keita, Oksala, Niku, Nakao, Atsunori, Lindgren, Leena, Killeen, Meaghan E, Mennander, Ari, Fink, Mitchell P, Tenhunen, Jyrki

“…Lipopolysaccharide (LPS) is an important factor in sepsis. LPS given by intraperitoneal injection induces intestinal hyperpermeability and bacterial…”
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Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock by Yang, Runkuan, Gallo, David J, Baust, Jeffrey J, Uchiyama, Takashi, Watkins, Simon K, Delude, Russell L, Fink, Mitchell P

“…Administration of pyruvate, an effective scavenger of reactive oxygen species, has been shown to be salutary in numerous models of redox-mediated tissue or…”
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Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis by Yang, Runkuan, Uchiyama, Takashi, Alber, Sean M, Han, Xiaonan, Watkins, Simon K, Delude, Russell L, Fink, Mitchell P

“…OBJECTIVE:Ethyl pyruvate has been shown to be an effective anti-inflammatory agent in a variety of in vitro and in vivo model systems. Herein, we used a murine…”
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The role of RAGE in the pathogenesis of intestinal barrier dysfunction after hemorrhagic shock by Raman, Kathleen G, Sappington, Penny L, Yang, Runkuan, Levy, Ryan M, Prince, Jose M, Liu, Shiguang, Watkins, Simon K, Schmidt, Ann Marie, Billiar, Timothy R, Fink, Mitchell P

“…The receptor for advanced glycation end products (RAGE) has been implicated in the pathogenesis of numerous conditions associated with excessive inflammation…”
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Bile modulates intestinal epithelial barrier function via an extracellular signal related kinase 1/2 dependent mechanism by RUNKUAN YANG, HARADA, Tomoyuki, JINYOU LI, UCHIYAMA, Takashi, YUSHENG HAN, ENGLERT, Joshua A, FINK, Mitchell P

“…Obstructive jaundice is frequently complicated by infections and has been associated with increased bacterial translocation and gut mucosal hyperpermeability…”
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