Search Results - "RUNGBY, JØRGEN"

Effects of Ketone Bodies on Brain Metabolism and Function in Neurodegenerative Diseases by Jensen, Nicole Jacqueline, Wodschow, Helena Zander, Nilsson, Malin, Rungby, Jørgen

“…Under normal physiological conditions the brain primarily utilizes glucose for ATP generation. However, in situations where glucose is sparse, e.g., during…”
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Neprilysin activity is increased in metabolic dysfunction-associated steatotic liver disease and normalizes after bariatric surgery or GLP-1 therapy by Kjeldsen, Sasha A.S., Gluud, Lise L., Werge, Mikkel P., Pedersen, Julie S., Bendtsen, Flemming, Alexiadou, Kleopatra, Tan, Tricia, Torekov, Signe S., Iepsen, Eva W., Jensen, Nicole J., Richter, Michael M., Goetze, Jens P., Rungby, Jørgen, Hartmann, Bolette, Holst, Jens J., Holst, Birgitte, Holt, Joachim, Gustafsson, Finn, Madsbad, Sten, Svane, Maria S., Bojsen-Møller, Kirstine N., Wewer Albrechtsen, Nicolai J.

“…Inhibitors of neprilysin improve glycemia in patients with heart failure and type 2 diabetes (T2D). The effect of weight loss by diet, surgery, or…”
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Blood-Brain Glucose Transfer in Alzheimer’s disease: Effect of GLP-1 Analog Treatment by Gejl, Michael, Brock, Birgitte, Egefjord, Lærke, Vang, Kim, Rungby, Jørgen, Gjedde, Albert

“…There are fewer than normal glucose transporters at the blood-brain barrier (BBB) in Alzheimer’s disease (AD). When reduced expression of transporters…”
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Sulfonylureas and the risk of myocardial infarction by Thisted, Henriette, Johnsen, Søren Paaske, Rungby, Jørgen

“…Patients with diabetes mellitus have an increased risk of coronary artery diseases such as myocardial infarction. Sulfonylureas are used in the treatment of…”
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Antidiabetic medication and risk of dementia in patients with type 2 diabetes: a nested case–control study by Wium-Andersen, Ida Kim, Osler, Merete, Jørgensen, Martin Balslev, Rungby, Jørgen, Wium-Andersen, Marie Kim

“…Objective Diabetes is a risk factor for dementia, but whether antidiabetic medication decreases the risk is unclear. We examined the association between…”
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Zinc transporter gene expression is regulated by pro-inflammatory cytokines: a potential role for zinc transporters in beta-cell apoptosis? by Egefjord, Laerke, Jensen, Jens Ledet, Bang-Berthelsen, Claus Heiner, Petersen, Andreas Brønden, Smidt, Kamille, Schmitz, Ole, Karlsen, Allan Ertman, Pociot, Flemming, Chimienti, Fabrice, Rungby, Jørgen, Magnusson, Nils E

“…Beta-cells are extremely rich in zinc and zinc homeostasis is regulated by zinc transporter proteins. beta-cells are sensitive to cytokines, interleukin-1beta…”
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Diabetes, antidiabetic medications and risk of depression – A population-based cohort and nested case-control study by Wium-Andersen, Ida Kim, Osler, Merete, Jørgensen, Martin Balslev, Rungby, Jørgen, Wium-Andersen, Marie Kim

“…Diabetes type 2 is associated with depression, but the impact of antidiabetic drugs is not clear. The objective was to analyze the association between diabetes…”
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Glucagonlike peptide‐1 receptor agonists versus dipeptidyl peptidase‐4 inhibitors in ischemic strokes with diabetes 2 by Hastrup, Sidsel, Hedegaard, Jakob Nebeling, Andersen, Grethe, Rungby, Jørgen, Johnsen, Soren Paaske

“…Background and purpose Cardiovascular outcome trials demonstrate that glucagonlike peptide‐1 receptor agonists (GLP‐1RAs) reduce the risk of major adverse…”
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In Alzheimer's disease, amyloid beta accumulation is a protective mechanism that ultimately fails by Rischel, Elise Brøchner, Gejl, Michael, Brock, Birgitte, Rungby, Jørgen, Gjedde, Albert

“…Hypothesis and predictions Here, we claim that amyloid beta (Aβ) accumulation is a protective mechanism that ultimately fails. We predict that more Aβ…”
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Multiple Soluble Components of the Glycocalyx Are Increased in Patient Plasma After Ischemic Stroke by DellaValle, Brian, Hasseldam, Henrik, Johansen, Flemming F, Iversen, Helle K, Rungby, Jørgen, Hempel, Casper

“…BACKGROUND AND PURPOSE—The GLX (glycocalyx) is a protein/polysaccharide meshwork at the cellular surface. Consisting largely of glycosaminoglycans and…”
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Bone resorption is unchanged by liraglutide in type 2 diabetes patients: A randomised controlled trial by Hygum, Katrine, Harsløf, Torben, Jørgensen, Niklas Rye, Rungby, Jørgen, Pedersen, Steen B., Langdahl, Bente L.

“…Liraglutide, a glucagon-like peptide-1 receptor agonist, has well known beneficial effects on glucose metabolism, and animal studies indicate that liraglutide…”
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The impact of obesity on chronic oedema/lymphoedema of the leg – an international multicenter cross-sectional study (LIMPRINT) by Burian, Ewa Anna, Rungby, Jørgen, Karlsmark, Tonny, Nørregaard, Susan, Cestari, Marina, Franks, Peter J., Moffatt, Christine Joy

“…Background/Objectives Obesity and chronic oedema/lymphoedema are two distinct but related conditions, rarely investigated together. The aim was to study the…”
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In Alzheimer's Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial by Gejl, Michael, Gjedde, Albert, Egefjord, Lærke, Møller, Arne, Hansen, Søren B, Vang, Kim, Rodell, Anders, Brændgaard, Hans, Gottrup, Hanne, Schacht, Anna, Møller, Niels, Brock, Birgitte, Rungby, Jørgen

“…In animal models, the incretin hormone GLP-1 affects Alzheimer's disease (AD). We hypothesized that treatment with GLP-1 or an analog of GLP-1 would prevent…”
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CRP, C-Peptide, and Risk of First-Time Cardiovascular Events and Mortality in Early Type 2 Diabetes: A Danish Cohort Study by Gedebjerg, Anne, Bjerre, Mette, Kjaergaard, Alisa Devedzic, Nielsen, Jens Steen, Rungby, Jørgen, Brandslund, Ivan, Maeng, Michael, Beck-Nielsen, Henning, Vaag, Allan, Sørensen, Henrik Toft, Hansen, Troels Krarup, Thomsen, Reimar Wernich

“…We investigated the relationship between hs-CRP, a marker of low-grade inflammation, alone or in combination with C-peptide, a marker of…”
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Experimental non-severe hypoglycaemia substantially impairs cognitive function in type 2 diabetes: a randomised crossover trial by Nilsson, Malin, Jensen, Nicole, Gejl, Michael, Bergmann, Marianne L., Storgaard, Heidi, Zander, Mette, Miskowiak, Kamilla, Rungby, Jørgen

“…Aims/hypothesis Previous studies have demonstrated a relationship between cognitive impairment and hypoglycaemia (<3 mmol/l). This study hypothesised that…”
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Effects of β-hydroxybutyrate on cognition in patients with type 2 diabetes by Jensen, Nicole Jacqueline, Nilsson, Malin, Ingerslev, Jonas Schultz, Olsen, Dorte Aalund, Fenger, Mogens, Svart, Mads, Møller, Niels, Zander, Mette, Miskowiak, Kamilla Woznica, Rungby, Jørgen

“…Objective Cognitive impairment in type 2 diabetes is associated with cerebral glucose hypometabolism. Providing a glucose substitute such as ketone bodies…”
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The zinc transporter Zip14 (SLC39a14) affects Beta-cell Function: Proteomics, Gene expression, and Insulin secretion studies in INS-1E cells by Maxel, Trine, Smidt, Kamille, Petersen, Charlotte C., Honoré, Bent, Christensen, Anne K., Jeppesen, Per B., Brock, Birgitte, Rungby, Jørgen, Palmfeldt, Johan, Larsen, Agnete

“…Insulin secretion from pancreatic beta-cells is dependent on zinc ions as essential components of insulin crystals, zinc transporters are thus involved in the…”
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Relation of Insulin Resistance to Brain Glucose Metabolism in Fasting and Hyperinsulinemic States: A Systematic Review and Meta-Analysis by Jensen, Nicole J, Porse, Ane J, Wodschow, Helena Z, Speyer, Helene, Krogh, Jesper, Marner, Lisbeth, Gejl, Michael, Gjedde, Albert, Rungby, Jørgen

“…Abnormal brain glucose metabolism may cause cognitive disease in type 2 diabetes, yet the relation between insulin resistance and brain glucose metabolism has…”
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Prolonged fasting-induced metabolic signatures in human skeletal muscle of lean and obese men by Bak, Ann Mosegaard, Vendelbo, Mikkel Holm, Christensen, Britt, Viggers, Rikke, Bibby, Bo Martin, Rungby, Jørgen, Jørgensen, Jens Otto Lunde, Møller, Niels, Jessen, Niels

“…Insulin resistance is a well-known physiological adaptation to prolonged fasting in healthy skeletal muscle. Obesity is associated with insulin resistance and…”
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Mannose-Binding Lectin and Risk of Cardiovascular Events and Mortality in Type 2 Diabetes: A Danish Cohort Study by Gedebjerg, Anne, Bjerre, Mette, Kjaergaard, Alisa Devedzic, Steffensen, Rudi, Nielsen, Jens Steen, Rungby, Jørgen, Friborg, Søren Gunnar, Brandslund, Ivan, Thiel, Steffen, Beck-Nielsen, Henning, Sørensen, Henrik Toft, Hansen, Troels Krarup, Thomsen, Reimar Wernich

“…Mannose-binding lectin (MBL) is linked to risk of cardiovascular disease (CVD) in diabetes, but the nature of the association is unclear. We investigated the…”
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