Search Results - "RUMIO, Cristiano"

Glycolysis-induced drug resistance in tumors—A response to danger signals? by Marcucci, Fabrizio, Rumio, Cristiano

“…Tumor cells often switch from mitochondrial oxidative metabolism to glycolytic metabolism even under aerobic conditions. Tumor cell glycolysis is accompanied…”
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The tumor-promoting effects of the adaptive immune system: a cause of hyperprogressive disease in cancer? by Marcucci, Fabrizio, Rumio, Cristiano

“…Adaptive antitumor immune responses, either cellular or humoral, aim at eliminating tumor cells expressing the cognate antigens. There are some instances,…”
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Tumor Cell Glycolysis-At the Crossroad of Epithelial-Mesenchymal Transition and Autophagy by Marcucci, Fabrizio, Rumio, Cristiano

“…Upregulation of glycolysis, induction of epithelial-mesenchymal transition (EMT) and macroautophagy (hereafter autophagy), are phenotypic changes that occur in…”
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On the Role of Glycolysis in Early Tumorigenesis-Permissive and Executioner Effects by Marcucci, Fabrizio, Rumio, Cristiano

“…Reprogramming energy production from mitochondrial respiration to glycolysis is now considered a hallmark of cancer. When tumors grow beyond a certain size…”
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The role of glycolysis in tumorigenesis: From biological aspects to therapeutic opportunities by Cordani, Marco, Michetti, Federica, Zarrabi, Ali, Zarepour, Atefeh, Rumio, Cristiano, Strippoli, Raffaele, Marcucci, Fabrizio

“…Glycolytic metabolism generates energy and intermediates for biomass production. Tumor-associated glycolysis is upregulated compared to normal tissues in…”
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The Vicious Cross-Talk between Tumor Cells with an EMT Phenotype and Cells of the Immune System by Romeo, Elisabetta, Caserta, Carmelo Antonio, Rumio, Cristiano, Marcucci, Fabrizio

“…Carcinoma cells that undergo an epithelial-mesenchymal transition (EMT) and display a predominantly mesenchymal phenotype (hereafter EMT tumor cells) are…”
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Toll-like Receptors 3, 4, and 7 Are Expressed in the Enteric Nervous System and Dorsal Root Ganglia by Barajon, Isabella, Serrao, Graziano, Arnaboldi, Francesca, Opizzi, Emanuela, Ripamonti, Gerlomina, Balsari, Andrea, Rumio, Cristiano

“…The aim of the present study was to evaluate the expression of innate immunity receptors belonging to the Toll-like family in the neural plexuses of the…”
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How Tumor Cells Choose Between Epithelial-Mesenchymal Transition and Autophagy to Resist Stress-Therapeutic Implications by Marcucci, Fabrizio, Rumio, Cristiano

“…Tumor cells undergo epithelial-mesenchymal transition (EMT) or macroautophagy (hereafter autophagy) in response to stressors from the microenvironment. EMT…”
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T cell costimulation blockade blunts pressure overload-induced heart failure by Kallikourdis, Marinos, Martini, Elisa, Carullo, Pierluigi, Sardi, Claudia, Roselli, Giuliana, Greco, Carolina M., Vignali, Debora, Riva, Federica, Ormbostad Berre, Anne Marie, Stølen, Tomas O., Fumero, Andrea, Faggian, Giuseppe, Di Pasquale, Elisa, Elia, Leonardo, Rumio, Cristiano, Catalucci, Daniele, Papait, Roberto, Condorelli, Gianluigi

“…Heart failure (HF) is a leading cause of mortality. Inflammation is implicated in HF, yet clinical trials targeting pro-inflammatory cytokines in HF were…”
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Depleting Tumor Cells Expressing Immune Checkpoint Ligands-A New Approach to Combat Cancer by Marcucci, Fabrizio, Rumio, Cristiano

“…Antibodies against inhibitory immune checkpoint molecules (ICPMs), referred to as immune checkpoint inhibitors (ICIs), have gained a prominent place in cancer…”
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Antibody-Drug Conjugates (ADC) Against Cancer Stem-Like Cells (CSC)-Is There Still Room for Optimism? by Marcucci, Fabrizio, Caserta, Carmelo Antonio, Romeo, Elisabetta, Rumio, Cristiano

“…Cancer stem-like cells (CSC) represent a subpopulation of tumor cells with peculiar functionalities that distinguish them from the bulk of tumor cells, most…”
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Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis by Sangaletti, Sabina, Di Carlo, Emma, Gariboldi, Silvia, Miotti, Silvia, Cappetti, Barbara, Parenza, Mariella, Rumio, Cristiano, Brekken, Rolf A, Chiodoni, Claudia, Colombo, Mario P

“…Other than genetic imprinting and epithelial to mesenchymal transition, cancer cells need interaction with the nearby stroma toward metastasis. Secreted…”
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The Fractalkine-Receptor Axis Improves Human Colorectal Cancer Prognosis by Limiting Tumor Metastatic Dissemination by Erreni, Marco, Siddiqui, Imran, Marelli, Giulia, Grizzi, Fabio, Bianchi, Paolo, Morone, Diego, Marchesi, Federica, Celesti, Giuseppe, Pesce, Samantha, Doni, Andrea, Rumio, Cristiano, Roncalli, Massimo G, Laghi, Luigi, Mantovani, Alberto, Allavena, Paola

“…Human colorectal cancer (CRC) is a frequent neoplasia in Western countries, and its metastatic progression is a major cause of cancer-related death. In search…”
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Induction of Paneth cell degranulation by orally administered Toll-like receptor ligands by Rumio, Cristiano, Sommariva, Michele, Sfondrini, Lucia, Palazzo, Marco, Morelli, Daniele, Viganò, Laura, De Cecco, Loris, Tagliabue, Elda, Balsari, Andrea

“…The secretory activity of Paneth cells is related to the bacterial milieu in the small intestine; however, the molecules involved in inducing Paneth cell…”
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Three months of Western diet induces small intestinal mucosa alteration in TLR KO mice by Sardi, Claudia, Luchini, Patrizia, Emanuelli, Andrea, Giannoni, Amedeo, Martini, Elisa, Manara, Lucia M, Sfondrini, Lucia, Kallikourdis, Marinos, Sommariva, Michele, Rumio, Cristiano

“…Several studies support the role of Western‐style diet (WD) in inflammatory bowel disease (IBD). Toll‐like receptors/NOD‐like receptors (TLRs/NLRs) are…”
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Critical Role of TLR9 in Acute Graft-versus-Host Disease by Calcaterra, Claudia, Sfondrini, Lucia, Rossini, Anna, Sommariva, Michele, Rumio, Cristiano, Menard, Sylvie, Balsari, Andrea

“…Graft-vs-host disease (GVHD) is a major complication after allogeneic bone marrow transplantation. Different studies have demonstrated that intestinal…”
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Activation of Enteroendocrine Cells via TLRs Induces Hormone, Chemokine, and Defensin Secretion by Palazzo, Marco, Balsari, Andrea, Rossini, Anna, Selleri, Silvia, Calcaterra, Claudia, Gariboldi, Silvia, Zanobbio, Laura, Arnaboldi, Francesca, Shirai, Yuri F, Serrao, Graziano, Rumio, Cristiano

“…Enteroendocrine cells are known primarily for their production of hormones that affect digestion, but they might also be implicated in sensing and neutralizing…”
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Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase by Borsello, Tiziana, Miniaci, Maria Concetta, Rumio, Cristiano, Tonna, Noemi, Lippiello, Pellegrino, Sclip, Alessandra, Buccarello, Lucia, Biggi, Silvia, Di Marino, Daniele

“…The c-Jun N-terminal kinase (JNK) is part of a stress signalling pathway strongly activated by NMDA-stimulation and involved in synaptic plasticity. Many…”
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Induction of pro-inflammatory programs in enteroendocrine cells by the Toll-like receptor agonists flagellin and bacterial LPS by Selleri, Silvia, Palazzo, Marco, Deola, Sara, Wang, Ena, Balsari, Andrea, Marincola, Francesco M., Rumio, Cristiano

“…Enteroendocrine cells are hormone-secreting cells spread along the intestinal epithelium. Their principal function is to promote the digestion of food…”
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The N-Terminal Fragment of Chromogranin A, Vasostatin-1 Protects Mice From Acute or Chronic Colitis Upon Oral Administration by Rumio, Cristiano, Dusio, Giuseppina F., Colombo, Barbara, Gasparri, Anna, Cardani, Diego, Marcucci, Fabrizio, Corti, Angelo

“…Background Vasostatin-1 (VS-1), the N-terminal fragment of chromogranin A (CgA), decreases the permeability of endothelial cells in vitro and in vivo. Aims…”
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