Search Results - "RUIZ, Phillip"

Intrinsic self-DNA triggers inflammatory disease dependent on STING by Ahn, Jeonghyun, Ruiz, Phillip, Barber, Glen N

“…Inflammatory diseases such as Aicardi-Goutières syndrome and severe systemic lupus erythematosus are generally lethal disorders that have been traced to…”
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Childhood Organ Transplantation by Phillip Ruiz, Gülden Diniz

“…Organ transplantation has significantly changed the life expectancy of patients with advanced organ failure. The quality of life with transplanted organs and…”
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Circulating urokinase receptor as a cause of focal segmental glomerulosclerosis by Wei, Changli, El Hindi, Shafic, Li, Jing, Fornoni, Alessia, Goes, Nelson, Sageshima, Junichiro, Maiguel, Dony, Karumanchi, S Ananth, Yap, Hui-Kim, Saleem, Moin, Zhang, Qingyin, Nikolic, Boris, Chaudhuri, Abanti, Daftarian, Pirouz, Salido, Eduardo, Torres, Armando, Salifu, Moro, Sarwal, Minnie M, Schaefer, Franz, Morath, Christian, Schwenger, Vedat, Zeier, Martin, Gupta, Vineet, Roth, David, Rastaldi, Maria Pia, Burke, George, Ruiz, Phillip, Reiser, Jochen

“…Focal segmental glomerulosclerosis (FSGS), or kidney scarring, is difficult to treat and is often only curable with kidney transplantation. However, FSGS often…”
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MYH9 E1841K Mutation Augments Proteinuria and Podocyte Injury and Migration by Cechova, Sylvia, Dong, Fan, Chan, Fang, Kelley, Michael J, Ruiz, Phillip, Le, Thu H

“…Intronic variants of the gene that encodes the nonmuscle myosin heavy chain IIA are associated with diabetic nephropathy in European Americans and with sickle…”
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Mechanisms of the proteinuria induced by Rho GTPases by Wang, Liming, Ellis, Mathew J, Gomez, Jose A, Eisner, William, Fennell, Walter, Howell, David N, Ruiz, Phillip, Fields, Timothy A, Spurney, Robert F

“…Podocytes are highly differentiated cells that play an important role in maintaining glomerular filtration barrier integrity; a function regulated by small…”
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Steroid-Free Immune Suppression Impairs Glycemic Control in a Healthy Cynomolgus Monkey by Berman, Dora M., Ruiz, Phillip, Blandino-Rosano, Manuel, Bernal-Mizrachi, Ernesto, Kenyon, Norma S.

“…The need for chronic immune suppression (IS) is one of the hurdles precluding widespread use of islet cell transplantation to restore glycemic control in…”
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Lymphocyte responses exacerbate angiotensin II-dependent hypertension by Crowley, Steven D, Song, Young-Soo, Lin, Eugene E, Griffiths, Robert, Kim, Hyung-Suk, Ruiz, Phillip

“…Activation of the immune system by ANG II contributes to the pathogenesis of hypertension, and pharmacological suppression of lymphocyte responses can…”
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Angiotensin II Causes Hypertension and Cardiac Hypertrophy through Its Receptors in the Kidney by Crowley, Steven D., Gurley, Susan B., Herrera, Maria J., Ruiz, Phillip, Griffiths, Robert, Kumar, Anil P., Kim, Hyung-Suk, Smithies, Oliver, Le, Thu H., Coffman, Thomas M.

“…Essential hypertension is a common disease, yet its pathogenesis is not well understood. Altered control of sodium excretion in the kidney may be a key…”
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Inflammation-driven carcinogenesis is mediated through STING by Ahn, Jeonghyun, Xia, Tianli, Konno, Hiroyasu, Konno, Keiko, Ruiz, Phillip, Barber, Glen N.

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Type 1 angiotensin receptors on macrophages ameliorate IL-1 receptor-mediated kidney fibrosis by Zhang, Jian-dong, Patel, Mehul B, Griffiths, Robert, Dolber, Paul C, Ruiz, Phillip, Sparks, Matthew A, Stegbauer, Johannes, Jin, Huixia, Gomez, Jose A, Buckley, Anne F, Lefler, William S, Chen, Daian, Crowley, Steven D

“…In a wide array of kidney diseases, type 1 angiotensin (AT1) receptors are present on the immune cells that infiltrate the renal interstitium. Here, we…”
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Transplantation: platform to study recurrence of disease by Burke, George William, Mitrofanova, Alla, Fontanella, Antonio Miguel, Vendrame, Francesco, Ciancio, Gaetano, Vianna, Rodrigo M, Roth, David, Ruiz, Phillip, Abitbol, Carolyn L, Chandar, Jayanthi, Merscher, Sandra, Pugliese, Alberto, Fornoni, Alessia

“…Beyond the direct benefit that a transplanted organ provides to an individual recipient, the study of the transplant process has the potential to create a…”
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Kidney-derived c-kit+ progenitor/stem cells contribute to podocyte recovery in a model of acute proteinuria by Rangel, Erika B., Gomes, Samirah A., Kanashiro-Takeuchi, Rosemeire, Saltzman, Russell G., Wei, Changli, Ruiz, Phillip, Reiser, Jochen, Hare, Joshua M.

“…Kidney-derived c-kit + cells exhibit progenitor/stem cell properties and can regenerate epithelial tubular cells following ischemia-reperfusion injury in rats…”
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Computed Tomography-Guided Kidney Transplant Biopsy Outcomes: A Single-Center Experience by Cortesi, Camilo, Sedki, Mai, Ruiz, Phillip, Salsamendi, Jason, Mattiazzi, Adela

“…Objectives: Percutaneous kidney transplant biopsy is typically performed using ultrasonographic guidance; computed tomography is an alternative modality used…”
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Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis by Snider, Ashley J, Ruiz, Phillip, Obeid, Lina M, Oates, Jim C

“…Sphingosine-1-phosphate (S1P), a potent bioactive lipid, is emerging as a central mediator in inflammation and immune responses. We have previously implicated…”
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Podocyte-specific overexpression of wild type or mutant trpc6 in mice is sufficient to cause glomerular disease by Krall, Paola, Canales, Cesar P, Kairath, Pamela, Carmona-Mora, Paulina, Molina, Jessica, Carpio, J Daniel, Ruiz, Phillip, Mezzano, Sergio A, Li, Jing, Wei, Changli, Reiser, Jochen, Young, Juan I, Walz, Katherina

“…Mutations in the TRPC6 calcium channel (Transient receptor potential channel 6) gene have been associated with familiar forms of Focal and Segmental…”
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Podocytes exhibit a specialized protein quality control employing derlin-2 in kidney disease by Ren, Guohui, Tardi, Nicholas J, Matsuda, Fumihiko, Koh, Kwi Hye, Ruiz, Phillip, Wei, Changli, Altintas, Mehmet M, Ploegh, Hidde, Reiser, Jochen

“…Podocytes are terminally differentiated cells of the kidney filtration barrier with a limited proliferative capacity and are the primary glomerular target for…”
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Achalasia as an Unusual Cause of Acute Cellular Rejection of a Transplanted Heart by Fernandes, Amanda, Yan, Crystal Lihong, Ruiz, Phillip, Thakkar Rivera, Nina

“…A 68-year-old female with end-stage heart failure presented to the hospital for heart transplant. She was diagnosed with achalasia 14 months prior and treated…”
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Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease by Maiguel, Dony, Faridi, Mohd Hafeez, Wei, Changli, Kuwano, Yoshihiro, Balla, Keir M, Hernandez, Dayami, Barth, Constantinos J, Lugo, Geanncarlo, Donnelly, Mary, Nayer, Ali, Moita, Luis F, Schürer, Stephan, Traver, David, Ruiz, Phillip, Vazquez-Padron, Roberto I, Ley, Klaus, Reiser, Jochen, Gupta, Vineet

“…The integrin CD11b/CD18 (also known as Mac-1), which is a heterodimer of the α(M) (CD11b) and β(2) (CD18) subunits, is critical for leukocyte adhesion and…”
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The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice by Sekine, Hideharu, Kinser, Ting Ting Hsieh, Qiao, Fei, Martinez, Efrain, Paulling, Emily, Ruiz, Phillip, Gilkeson, Gary S., Tomlinson, Stephen

“…Objective Complement has both protective and pathogenic functions in lupus due to a balance between its role in the clearance of immune complexes (ICs) and…”
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Stimulation of lymphocyte responses by angiotensin II promotes kidney injury in hypertension by Crowley, Steven D, Frey, Campbell W, Gould, Samantha K, Griffiths, Robert, Ruiz, Phillip, Burchette, James L, Howell, David N, Makhanova, Natalia, Yan, Ming, Kim, Hyung-Suk, Tharaux, Pierre-Louis, Coffman, Thomas M

“…Activation of the renin-angiotensin system contributes to the progression of chronic kidney disease. Based on the known cellular effects of ANG II to promote…”
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