Search Results - "RUILAN YAN"

Large, Diverse Population Cohorts of hiPSCs and Derived Hepatocyte-like Cells Reveal Functional Genetic Variation at Blood Lipid-Associated Loci by Pashos, Evanthia E., Park, YoSon, Wang, Xiao, Raghavan, Avanthi, Yang, Wenli, Abbey, Deepti, Peters, Derek T., Arbelaez, Juan, Hernandez, Mayda, Kuperwasser, Nicolas, Li, Wenjun, Lian, Zhaorui, Liu, Ying, Lv, Wenjian, Lytle-Gabbin, Stacey L., Marchadier, Dawn H., Rogov, Peter, Shi, Jianting, Slovik, Katherine J., Stylianou, Ioannis M., Wang, Li, Yan, Ruilan, Zhang, Xiaolan, Kathiresan, Sekar, Duncan, Stephen A., Mikkelsen, Tarjei S., Morrisey, Edward E., Rader, Daniel J., Brown, Christopher D., Musunuru, Kiran

“…Genome-wide association studies have struggled to identify functional genes and variants underlying complex phenotypes. We recruited a multi-ethnic cohort of…”
Get full text

Aldo-keto Reductase Family 1 Member B10 Promotes Cell Survival by Regulating Lipid Synthesis and Eliminating Carbonyls by Wang, Chun, Yan, Ruilan, Luo, Dixian, Watabe, Kounosuke, Liao, Duan-Fang, Cao, Deliang

“…Aldo-keto reductase family 1 member B10 (AKR1B10) is primarily expressed in the normal human colon and small intestine but overexpressed in liver and lung…”
Get full text

Aldo–keto reductase family 1 B10 gene silencing results in growth inhibition of colorectal cancer cells: Implication for cancer intervention by Yan, Ruilan, Zu, Xuyu, Ma, Jun, Liu, Ziwen, Adeyanju, Moses, Cao, Deliang

“…Aldo–keto reductase family 1 B10 (AKR1B10), a member of aldo–keto reductase superfamily, is overexpressed in human hepatocellular carcinoma, lung squamous cell…”
Get full text

Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol by Androic, Ilija, Krämer, Andrea, Yan, Ruilan, Rödel, Franz, Gätje, Regine, Kaufmann, Manfred, Strebhardt, Klaus, Yuan, Juping

“…Cyclin B1, the regulatory subunit of cyclin-dependent kinase 1 (Cdk1), is essential for the transition from G2 phase to mitosis. Cyclin B1 is very often found…”
Get full text

Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells by JUPING YUAN, RUILAN YAN, KRÄMER, Andrea, ECKERDT, Frank, ROLLER, Marc, KAUFMANN, Manfred, STREBHARDT, Klaus

“…Cyclin B1 is the regulatory subunit of M-phase promoting factor, and proper regulation of cyclin B1 is essential for the initiation of mitosis. Increasing…”
Get full text

Evaluation of a rapid multi-attribute combinatorial high-throughput UV-Vis/DLS/SLS analytical platform for rAAV quantification and characterization by Liu, Xueyuan, Jean-Gilles, Riffard, Baginski, Julia, Cai, Christina, Yan, Ruilan, Zhang, Lili, Lance, Kevin, van der Loo, Johannes C.M., Davidson, Beverly L.

“…Recombinant adeno-associated virus (rAAV)-based gene therapies are expanding in their application. Despite progress in manufacturing, current analytical…”
Get full text

Aldo–keto reductase family 1 B10 protein detoxifies dietary and lipid-derived alpha, beta-unsaturated carbonyls at physiological levels by Zhong, Linlin, Liu, Ziwen, Yan, Ruilan, Johnson, Stephen, Zhao, Yupei, Fang, Xiubin, Cao, Deliang

“…Alpha, beta-unsaturated carbonyls are highly reactive mutagens and carcinogens to which humans are exposed on a daily basis. This study demonstrates that…”
Get full text

ATP-Binding Cassette Transporter A1 Deficiency in Human Induced Pluripotent Stem Cell-Derived Hepatocytes Abrogates HDL Biogenesis and Enhances Triglyceride Secretion by Bi, Xin, Pashos, Evanthia E., Cuchel, Marina, Lyssenko, Nicholas N., Hernandez, Mayda, Picataggi, Antonino, McParland, James, Yang, Wenli, Liu, Ying, Yan, Ruilan, Yu, Christopher, DerOhannessian, Stephanie L., Phillips, Michael C., Morrisey, Edward E., Duncan, Stephen A., Rader, Daniel J.

“…Despite the recognized role of the ATP-binding Cassette Transporter A1 (ABCA1) in high-density lipoprotein (HDL) metabolism, our understanding of ABCA1…”
Get full text

Differential expression of uridine phosphorylase in tumors contributes to an improved fluoropyrimidine therapeutic activity by Cao, Deliang, Ziemba, Amy, McCabe, James, Yan, Ruilan, Wan, Laxiang, Kim, Bradford, Gach, Michael, Flynn, Stuart, Pizzorno, Giuseppe

“…Abrogation of uridine phosphorylase (UPase) leads to abnormalities in pyrimidine metabolism and host protection against 5-fluorouracil (5-FU) toxicity. We…”
Get full text

Cyclin C mediates stress-induced mitochondrial fission and apoptosis by Wang, Kun, Yan, Ruilan, Cooper, Katrina F, Strich, Randy

“…Mitochondria are dynamic organelles that undergo constant fission and fusion cycles. In response to cellular damage, this balance is shifted dramatically…”
Get full text

Synergistic repression of thyroid hyperplasia by cyclin C and Pten by Jezek, Jan, Wang, Kun, Yan, Ruilan, Di Cristofano, Antonio, Cooper, Katrina F, Strich, Randy

“…The cyclin C-Cdk8 kinase has been identified as both a tumor suppressor and an oncogene depending on the cell type. The genomic locus encoding cyclin C ( ) is…”
Get full text

Functional Analysis and Transcriptomic Profiling of iPSC-Derived Macrophages and Their Application in Modeling Mendelian Disease by Zhang, Hanrui, Xue, Chenyi, Shah, Rhia, Bermingham, Kate, Hinkle, Christine C, Li, Wenjun, Rodrigues, Amrith, Tabita-Martinez, Jennifer, Millar, John S, Cuchel, Marina, Pashos, Evanthia E, Liu, Ying, Yan, Ruilan, Yang, Wenli, Gosai, Sager J, VanDorn, Daniel, Chou, Stella T, Gregory, Brian D, Morrisey, Edward E, Li, Mingyao, Rader, Daniel J, Reilly, Muredach P

“…RATIONALE:An efficient and reproducible source of genotype-specific human macrophages is essential for study of human macrophage biology and related diseases…”
Get full text

Aldo-keto Reductase Family 1 B10 Affects Fatty Acid Synthesis by Regulating the Stability of Acetyl-CoA Carboxylase-α in Breast Cancer Cells by Ma, Jun, Yan, Ruilan, Zu, Xuyu, Cheng, Ji-Ming, Rao, Krishna, Liao, Duan-Fang, Cao, Deliang

“…Recent studies have demonstrated that aldo-keto reductase family 1 B10 (AKR1B10), a novel protein overexpressed in human hepatocellular carcinoma and non-small…”
Get full text

Impaired self-renewal and increased colitis and dysplastic lesions in colonic mucosa of AKR1B8-deficient mice by Shen, Yi, Ma, Jun, Yan, Ruilan, Ling, Hongyan, Li, Xiaoning, Yang, Wancai, Gao, John, Huang, Chenfei, Bu, Yiwen, Cao, Yu, He, Yingchun, Wan, Laxiang, Zu, Xuyu, Liu, Jianghua, Huang, Mei Chris, Stenson, William F, Liao, Duan-Fang, Cao, Deliang

“…Ulcerative colitis and colitis-associated colorectal cancer (CAC) is a serious health issue, but etiopathological factors remain unclear. Aldo-keto reductase…”
Get full text

Aldo‐keto reductase 1B10 protects human colon cells from DNA damage induced by electrophilic carbonyl compounds by Zu, Xuyu, Yan, Ruilan, Pan, Jishen, Zhong, Linlin, Cao, Yu, Ma, Jun, Cai, Chuan, Huang, Dan, Liu, Jianghua, Chung, Fung‐Lung, Liao, Duan‐Fang, Cao, Deliang

“…Electrophilic carbonyl compounds are highly cytotoxic and genotoxic. Aldo‐keto reductase 1B10 (AKR1B10) is an enzyme catalyzing reduction of carbonyl compounds…”
Get full text

Epidermal growth factor induces tumour marker AKR1B10 expression through activator protein-1 signalling in hepatocellular carcinoma cells by Liu, Ziwen, Yan, Ruilan, Al-Salman, Ahmed, Shen, Yi, Bu, Yiwen, Ma, Jun, Luo, Di-Xian, Huang, Chenfei, Jiang, Yuyang, Wilber, Andrew, Mo, Yin-Yuan, Huang, Mei Chris, Zhao, Yupei, Cao, Deliang

“…AKR1B10 (aldo-keto reductase 1B10) is overexpressed in liver and lung cancer, and plays a critical role in tumour development and progression through promoting…”
Get more information

Aldo-keto reductase 1B10 protects human colon cells from DNA damage induced by electrophilic carbonyl compounds: AKR1B10 PROTECTS HUMAN COLON CELLS FROM DNA DAMAGE by Zu, Xuyu, Yan, Ruilan, Pan, Jishen, Zhong, Linlin, Cao, Yu, Ma, Jun, Cai, Chuan, Huang, Dan, Liu, Jianghua, Chung, Fung-Lung, Liao, Duan-Fang, Cao, Deliang

Get full text

Abstract 5348: Impaired self-renewal and colitis susceptibility of colonic mucosa in mice lacking AKR1B8 by Shen, Yi, Ma, Jun, Yan, Ruilan, Ling, Hongyan, Li, Xiaoning, Yang, Wancai, Gao, John, Bu, Yiwen, Alsalman, Ahmed, Huang, Cheifei, Cao, Yu, Zhou, Shuangbai, Wan, Laxiang, He, Yingchun, Wang, Zhiqi, Khazaal, Ali, Huang, Mei Chris, Liao, Duan-Fang, Cao, Deliang

“…Abstract Background: Ulcerative colitis (UC) is a major clinically defined form of inflammatory bowel disease which affects individuals throughout a life and…”
Get full text

Su1809 A Novel Complex Microsatellite in the Akr1b10 Promoter as a Marker for Differentiation and Lymphatic Metastasis of Colorectal Cancer by Krishack, Paulette A, Markwell, Stephen, Yan, Ruilan, Bonacum, James, Robbins, Sara, Gao, John, Huang, Mei C, Cao, Delaing

Get full text

Reduced 293T Cell Susceptibility to Acrolein Due to Aldose Reductase–like-1 Protein Expression by Zu, Xuyu, Yan, Ruilan, Robbins, Sarah, Krishack, Paulette A., Liao, Duan-Fang, Cao, Deliang

“…Acrolein is a highly reactive α,β-unsaturated aldehyde produced endogenously during lipid peroxidation and naturally distributed pervasively in living…”
Get full text