Search Results - "RUELL, Jeffrey A"

PAMPA--a drug absorption in vitro model. 5. Unstirred water layer in iso-pH mapping assays and pKa(flux)--optimized design (pOD-PAMPA) by Ruell, Jeffrey A, Tsinman, Konstantin L, Avdeef, Alex

“…Iso-pH mapping unstirred parallel artificial membrane permeability assay (PAMPA) was used to measure the effective permeability, P(e), as a function of pH from…”
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PAMPA—a drug absorption in vitro model: 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones by Bermejo, Marival, Avdeef, Alex, Ruiz, Ana, Nalda, Ricardo, Ruell, Jeffrey A., Tsinman, Oksana, González, Isabel, Fernández, Carlos, Sánchez, Gloria, Garrigues, Teresa M., Merino, Virginia

“…Parallel artificial membrane permeability assay (PAMPA) was used to measure the effective permeability, P e, as a function of pH from 4 to 10, of 17…”
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Ionization, lipophilicity, and molecular modeling to investigate permeability and other biological properties of amlodipine by Caron, Giulia, Ermondi, Giuseppe, Damiano, Alessandro, Novaroli, Laura, Tsinman, Oksana, Ruell, Jeffrey A., Avdeef, Alex

“…[Display omitted] This paper uses a recent approach toward drug discovery, in which in silico tools and experimental data are combined together to study the…”
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New Alkenyldiarylmethanes with Enhanced Potencies as Anti-HIV Agents Which Act as Non-Nucleoside Reverse Transcriptase Inhibitors by Cushman, Mark, Casimiro-Garcia, Agustin, Hejchman, Elzbieta, Ruell, Jeffrey A, Huang, Mingjun, Schaeffer, Catherine A, Williamson, Karen, Rice, William G, Buckheit, Robert W

“…Twenty-two new alkenyldiarylmethanes (ADAMs) were synthesized and evaluated for inhibition of HIV-1 replication. The most potent compound proved to be methyl…”
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Synthesis and Anti-HIV Activity of Cosalane Analogues with Substituted Benzoic Acid Rings Attached to the Pharmacophore through Methylene and Amide Linkers by Ruell, Jeffrey A, De Clercq, Erik, Pannecouque, Christophe, Witvrouw, Myriam, Stup, Tracy L, Turpin, Jim A, Buckheit, Robert W, Cushman, Mark

“…The cosalane pharmacophore has been extended by the attachment of two additional substituted benzoic acid rings through amide and methylene linkers. The…”
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Extension of the Polyanionic Cosalane Pharmacophore as a Strategy for Increasing Anti-HIV Potency by Cushman, Mark, Insaf, Shabana, Paul, Gitendra, Ruell, Jeffrey A, De Clercq, Erik, Schols, Dominique, Pannecouque, Christophe, Witvrouw, Myriam, Schaeffer, Catherine A, Turpin, Jim A, Williamson, Karen, Rice, William G

“…The anti-HIV agent cosalane inhibits both the binding of gp120 to CD4 as well as an undefined postattachment event prior to reverse transcription. Several…”
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PAMPA—a drug absorption in vitro model by Ruell, Jeffrey A, Tsinman, Konstantin L, Avdeef, Alex

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PAMPA—a drug absorption in vitro model: 5. Unstirred water layer in iso-pH mapping assays and p Kaflux—optimized design ( pOD-PAMPA) by Ruell, Jeffrey A, Tsinman, Konstantin L, Avdeef, Alex

“…Iso-pH mapping unstirred parallel artificial membrane permeability assay (PAMPA) was used to measure the effective permeability, P e, as a function of pH from…”
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PAMPA: A drug absorption in vitro model. 5. Unstirred water layer in iso-pH mapping assays and pKfluxa-optimized design (pOD-PAMPA) by RUELL, Jeffrey A, TSINMAN, Konstantin L, AVDEEF, Alex

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PAMPA—a drug absorption in vitro model by Bermejo, Marival, Avdeef, Alex, Ruiz, Ana, Nalda, Ricardo, Ruell, Jeffrey A., Tsinman, Oksana, González, Isabel, Fernández, Carlos, Sánchez, Gloria, Garrigues, Teresa M., Merino, Virginia

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Synthesis of a cosalane analog with an extended polyanionic pharmacophore conferring enhanced potency as an anti-HIV agent by Cushman, Mark, Insaf, Shabana, Ruell, Jeffrey A., Schaeffer, Catherine A., Rice, William G.

“…A novel cosalane analog having an extended polyanionic pharmacophore was synthesized in order to target specific cationic residues on the surface of CD4. The…”
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