Search Results - "RUDY, BERNARDO"

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits by Tremblay, Robin, Lee, Soohyun, Rudy, Bernardo

“…Cortical networks are composed of glutamatergic excitatory projection neurons and local GABAergic inhibitory interneurons that gate signal flow and sculpt…”
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Layer-specific modulation of neocortical dendritic inhibition during active wakefulness by Muñoz, William, Tremblay, Robin, Levenstein, Daniel, Rudy, Bernardo

“…γ-Aminobutyric acid (GABA)ergic inputs are strategically positioned to gate synaptic integration along the dendritic arbor of pyramidal cells. However, their…”
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Mechanisms of inhibition within the telencephalon: "where the wild things are" by Fishell, Gord, Rudy, Bernardo

“…In this review, we first provide a historical perspective of inhibitory signaling from the discovery of inhibition through to our present understanding of the…”
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Spatiotemporal specificity in cholinergic control of neocortical function by Muñoz, William, Rudy, Bernardo

“…Highlights • Cholinergic actions with specific spatiotemporal patterns regulate cognition. • Both nicotinic and muscarinic responses can be fast and precise. •…”
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Diversity and Connectivity of Layer 5 Somatostatin-Expressing Interneurons in the Mouse Barrel Cortex by Nigro, Maximiliano José, Hashikawa-Yamasaki, Yoshiko, Rudy, Bernardo

“…Inhibitory interneurons represent 10-15% of the neurons in the somatosensory cortex, and their activity powerfully shapes sensory processing. Three major…”
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Neocortical Layer 1: An Elegant Solution to Top-Down and Bottom-Up Integration by Schuman, Benjamin, Dellal, Shlomo, Prönneke, Alvar, Machold, Robert, Rudy, Bernardo

“…Many of our daily activities, such as riding a bike to work or reading a book in a noisy cafe, and highly skilled activities, such as a professional playing a…”
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Perisomatic GABA Release and Thalamocortical Integration onto Neocortical Excitatory Cells Are Regulated by Neuromodulators by Kruglikov, Illya, Rudy, Bernardo

“…Neuromodulators such as acetylcholine, serotonin, and noradrenaline are powerful regulators of neocortical activity. Although it is well established that…”
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Genetic approaches to elucidating cortical and hippocampal GABAergic interneuron diversity by Machold, Robert, Rudy, Bernardo

“…GABAergic interneurons (INs) in the mammalian forebrain represent a diverse population of cells that provide specialized forms of local inhibition to regulate…”
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Neocortical Somatostatin-Expressing GABAergic Interneurons Disinhibit the Thalamorecipient Layer 4 by Xu, Han, Jeong, Hyo-Young, Tremblay, Robin, Rudy, Bernardo

“…Subtypes of GABAergic interneurons (INs) are crucial for cortical function, yet their specific roles are largely unknown. In contrast to supra- and…”
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Four Unique Interneuron Populations Reside in Neocortical Layer 1 by Schuman, Benjamin, Machold, Robert P, Hashikawa, Yoshiko, Fuzik, János, Fishell, Gord J, Rudy, Bernardo

“…Sensory perception depends on neocortical computations that contextually adjust sensory signals in different internal and environmental contexts. Neocortical…”
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Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons by Rudy, Bernardo, Fishell, Gordon, Lee, SooHyun, Hjerling‐Leffler, Jens

“…An understanding of the diversity of cortical GABAergic interneurons is critical to understand the function of the cerebral cortex. Recent data suggest that…”
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The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors by Lee, SooHyun, Hjerling-Leffler, Jens, Zagha, Edward, Fishell, Gord, Rudy, Bernardo

“…A highly diverse population of neocortical GABAergic inhibitory interneurons has been implicated in multiple functions in information processing within…”
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Mapping Cortical Integration of Sensory and Affective Pain Pathways by Singh, Amrita, Patel, Divya, Li, Anna, Hu, Lizbeth, Zhang, Qiaosheng, Liu, Yaling, Guo, Xinling, Robinson, Eric, Martinez, Erik, Doan, Lisa, Rudy, Bernardo, Chen, Zhe S., Wang, Jing

“…Pain is an integrated sensory and affective experience. Cortical mechanisms of sensory and affective integration, however, remain poorly defined. Here, we…”
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Strategies and Tools for Combinatorial Targeting of GABAergic Neurons in Mouse Cerebral Cortex by He, Miao, Tucciarone, Jason, Lee, SooHyun, Nigro, Maximiliano José, Kim, Yongsoo, Levine, Jesse Maurica, Kelly, Sean Michael, Krugikov, Illya, Wu, Priscilla, Chen, Yang, Gong, Ling, Hou, Yongjie, Osten, Pavel, Rudy, Bernardo, Huang, Z. Josh

“…Systematic genetic access to GABAergic cell types will facilitate studying the function and development of inhibitory circuitry. However, single gene-driven…”
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Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex by Valero, Manuel, Viney, Tim J., Machold, Robert, Mederos, Sara, Zutshi, Ipshita, Schuman, Benjamin, Senzai, Yuta, Rudy, Bernardo, Buzsáki, György

“…Pyramidal cells and GABAergic interneurons fire together in balanced cortical networks. In contrast to this general rule, we describe a distinct neuron type in…”
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Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels by Boronat, Anna, Gelfand, Jeffrey M., Gresa-Arribas, Nuria, Jeong, Hyo-Young, Walsh, Michael, Roberts, Kirk, Martinez-Hernandez, Eugenia, Rosenfeld, Myrna R., Balice-Gordon, Rita, Graus, Francesc, Rudy, Bernardo, Dalmau, Josep

“…Objective: To report a novel cell surface autoantigen of encephalitis that is a critical regulatory subunit of the Kv4.2 potassium channels. Methods: Four…”
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Weighing the evidence for a ternary protein complex mediating A-type K+ currents in neurons by Maffie, Jonathon, Rudy, Bernardo

“…The subthreshold-operating A-type K + current in neurons ( I SA ) has important roles in the regulation of neuronal excitability, the timing of action…”
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Channelrhodopsin-Assisted Patching: In Vivo Recording of Genetically and Morphologically Identified Neurons throughout the Brain by Muñoz, William, Tremblay, Robin, Rudy, Bernardo

“…Brain networks contain a large diversity of functionally distinct neuronal elements, each with unique properties, enabling computational capacities and…”
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K + Channels at the Axon Initial Segment Dampen Near-Threshold Excitability of Neocortical Fast-Spiking GABAergic Interneurons by Goldberg, Ethan M., Clark, Brian D., Zagha, Edward, Nahmani, Mark, Erisir, Alev, Rudy, Bernardo

“…Fast-spiking cells (FS cells) are a prominent subtype of neocortical GABAergic interneurons with important functional roles. Multiple FS cell properties are…”
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Satb1 is an activity-modulated transcription factor required for the terminal differentiation and connectivity of medial ganglionic eminence-derived cortical interneurons by Close, Jennie, Xu, Han, De Marco García, Natalia, Batista-Brito, Renata, Rossignol, Elsa, Rudy, Bernardo, Fishell, Gord

“…Although previous work identified transcription factors crucial for the specification and migration of parvalbumin (PV)-expressing and somatostatin…”
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