Search Results - "RUDDON, Raymond W"

Rationale for biomarkers and surrogate end points in mechanism-driven oncology drug development by PARK, John W, KERBEL, Robert S, KELLOFF, Gary J, BARRETT, J. Carl, CHABNER, Bruce A, PARKINSON, David R, PECK, Jonathan, RUDDON, Raymond W, SIGMAN, Caroline C, SLAMON, Dennis J

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Introduction to the molecular biology of cancer: translation to the clinic by Ruddon, Raymond W

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Goodman & Gilman's the pharmacological basis of therapeutics by Goodman, Louis S, Hardman, Joel G, Limbird, Lee E, Gilman, Alfred Goodman

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Use of CA-125 in clinical trial evaluation of new therapeutic drugs for ovarian cancer by RUSTIN, Gordon J. S, BAST, Robert C, KELLOFF, Gary J, BARRETT, J. Carl, CARTER, Stephen K, NISEN, Perry D, SIGMAN, Caroline C, PARKINSON, David R, RUDDON, Raymond W

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Reanalysis of cancer drugs: Old drugs, new tricks by VANDE WOUDE, George F, KELLOFF, Gary J, SLICHENMYER, William J, RUDDON, Raymond W, KOO, Han-Mo, SIGMAN, Caroline C, BARRETT, J. Carl, DAY, Robert W, DICKER, Adam P, KERBEL, Robert S, PARKINSON, David R

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Human Chorionic Gonadotropin-β Gene Expression in First Trimester Placenta by Miller-Lindholm, Amanda K., LaBenz, C. J., Ramey, Jacques, Bedows, Elliott, Ruddon, Raymond W.

“…Abstract The hCGβ gene family contains six genes linked in tandem on chromosome 19 and labeled β genes 7, 8, 5, 1, 2, and 3. Previous studies on a small number…”
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A Naturally Occurring Genetic Variant in the Human Chorionic Gonadotropin-β Gene 5 Is Assembly Inefficient by Miller-Lindholm, Amanda K., Bedows, Elliott, Bartels, Cynthia F., Ramey, Jacques, Maclin, Victoria, Ruddon, Raymond W.

“…Abstract The hCGβ gene family is composed of six homologous genes linked in tandem repeat on chromosome 19; the order of the genes is 7, 8, 5, 1, 2, and 3…”
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Biomarkers, Surrogate End Points, and the Acceleration of Drug Development for Cancer Prevention and Treatment by Kelloff, Gary J., Bast, Robert C., Coffey, Donald S., D’Amico, Anthony V., Kerbel, Robert S., Park, John W., Ruddon, Raymond W., Rustin, Gordon J. S., Schilsky, Richard L., Sigman, Caroline C., Woude, George F. Vande

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Intracellular Folding Pathway of the Cystine Knot-Containing Glycoprotein Hormone α-Subunit by Darling, Ryan J, Wilken, Jason A, Ruddon, Raymond W, Bedows, Elliott

“…Three of the five disulfide bonds in the glycoprotein hormone α-subunit (GPH-α) form a cystine knot motif that stabilizes a three-loop antiparallel structure…”
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Functional Contributions of Noncysteine Residues within the Cystine Knots of Human Chorionic Gonadotropin Subunits by Darling, Ryan J., Wilken, Jason A., Miller-Lindholm, Amanda K., Urlacher, Teresa M., Ruddon, Raymond W., Sherman, Simon A., Bedows, Elliott

“…Human chorionic gonadotropin (hCG) is a heterodimeric member of a family of cystine knot-containing proteins that contain the consensus sequences…”
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Super hormones by Ruddon, Raymond W

“…The glycoprotein hormones are a group of evolutionarily conserved hormones involved in the regulation of reproduction and metabolism. They are present in…”
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Dissociation of Early Folding Events from Assembly of the Human Lutropin β-Subunit by Muyan, Mesut, Ruddon, Raymond W, Norton, Sheila E, Boime, Irving, Bedows, Elliott

“…The human LH of the anterior pituitary is a member of the glycoprotein hormone family that includes FSH, TSH, and placental CG. All are noncovalently bound…”
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Assisted Protein Folding by Ruddon, Raymond W., Bedows, Elliott

“…Historical Perspectives The pioneering work of the late Christian Anfinsen and his colleagues on the reoxidation of bovine pancreatic ribonuclease (RNase) to a…”
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Biosynthesis and secretion of laminin and laminin-associated glycoproteins by nonmalignant and malignant human keratinocytes: comparison of cell lines from primary and secondary tumors in the same patient by FRENETTE, G. P, CAREY, T. E, VARANI, J, SCHWARTZ, D. R, FLIGIEL, S. E. G, RUDDON, R. W, PETERS, B. P

“…Laminin biosynthesis was compared in four pairs of human squamous cell carcinoma cultures derived from primary and recurrent or metastatic tumors in four…”
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Biomarkers, surrogate end points, and the acceleration of drug development for cancer prevention and treatment: An update by KELLOFF, Gary J, BAST, Robert C, WOUDE, George F, COFFEY, Donald S, D'AMICO, Anthony V, KERBEL, Robert S, PARK, John W, RUDDON, Raymond W, RUSTIN, Gordon J. S, SCHILSKY, Richard L, SIGMAN, Caroline C

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Carcinoembryonic antigen for monitoring patients with small cell carcinoma of the lung during treatment by Waalkes, T P, Abeloff, M D, Woo, K B, Ettinger, D S, Ruddon, R W, Aldenderfer, P

“…Carcinoembryonic antigen (CEA) was measured at specific intervals in the plasma of 56 patients with small cell carcinoma of the lung. Of these patients, 47 had…”
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Stimulation of synthesis and secretion of chorionic gonadotropin subunits by eutopic and ectopic hormone-producing human cell lines by Ruddon, R W, Anderson, C, Meade-Cobun, K S

“…The effects of dibutyryl cyclic adenosine 3'3':-5'-monophosphate (AMP) and sodium butyrate on the synthesis and secretion of human chorionic gonadotropin (HCG)…”
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Content of gonadotropins in cultured human malignant cells and effects of sodium butyrate treatment on gonadotropin secretion by HeLa cells by Ruddon, R W, Anderson, C, Meade, K S, Aldenderfer, P H, Neuwald, P D

“…Twenty-one of 82 human cell lines examined for production of human chorionic gonadotropin and its subunits (HCG-alpha and HCG-beta) produced either one or both…”
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Cystine knot mutations affect the folding of the glycoprotein hormone alpha-subunit. Differential secretion and assembly of partially folded intermediates by Darling, R J, Ruddon, R W, Perini, F, Bedows, E

“…The common glycoprotein hormone alpha-subunit (GPH-alpha) contains five intramolecular disulfide bonds, three of which form a cystine knot motif (10-60, 28-82,…”
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Catabolism of nuclear proteins in control and phytohemagglutinin-stimulated human lymphocytes, leukemic leukocytes, and Burkitt lymphoma cells by Weisenthal, L M, Ruddon, R W

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