Search Results - "RUDAZ, S"

Development and application of a liquid chromatography coupled to mass spectrometry method for the simultaneous determination of 23 antineoplastic drugs at trace levels by Fleury-Souverain, S., Maurin, J., Guillarme, D., Rudaz, S., Bonnabry, P.

“…The goal of this study was to develop a method for the simultaneous quantification of 23 commonly used antineoplastic drugs in a hospital pharmacy, using…”
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Restricted access materials and large particle supports for on-line sample preparation: an attractive approach for biological fluids analysis by Souverain, S, Rudaz, S, Veuthey, J.-L

“…An analytical process generally involves four main steps: (1) sample preparation; (2) analytical separation; (3) detection; and (4) data handling. In the…”
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Atmospheric pressure photoionization for coupling liquid-chromatography to mass spectrometry: A review by Marchi, Ivano, Rudaz, Serge, Veuthey, Jean-Luc

“…This review presents the state-of-the-art techniques that couple liquid chromatography (LC) and mass spectrometry (MS) via atmospheric pressure photoionization…”
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Coadministration of ticagrelor and ritonavir: Toward prospective dose adjustment to maintain an optimal platelet inhibition using the PBPK approach by Marsousi, N, Samer, CF, Fontana, P, Reny, JL, Rudaz, S, Desmeules, JA, Daali, Y

“…Ticagrelor is a potent antiplatelet drug metabolized by cytochrome (CYP)3A. It is contraindicated in patients with human immunodeficiency virus (HIV) because…”
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Fast analysis of doping agents in urine by ultra-high-pressure liquid chromatography–quadrupole time-of-flight mass spectrometry. II: Confirmatory analysis by Badoud, F., Grata, E., Perrenoud, L., Saugy, M., Rudaz, S., Veuthey, J.-L.

“…For doping control, analyses of samples are generally achieved in two steps: a rapid screening and, in the case of a positive result, a confirmatory analysis…”
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Fast analysis of doping agents in urine by ultra-high-pressure liquid chromatography-quadrupole time-of-flight mass spectrometry : I. Screening analysis by Badoud, F, Grata, E, Perrenoud, L, Avois, L, Saugy, M, Rudaz, S, Veuthey, J.-L

“…The general strategy to perform anti-doping analyses of urine samples starts with the screening for a wide range of compounds. This step should be fast,…”
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Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies by Nicoli, R., Bartolini, M., Rudaz, S., Andrisano, V., Veuthey, J.-L.

“…Two cytochrome P450 (CYP)-based immobilized enzyme reactors (IMERs) were developed to perform automated on-line phase I drug metabolism studies. For this…”
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Development of a bioreactor based on trypsin immobilized on monolithic support for the on-line digestion and identification of proteins by Calleri, E., Temporini, C., Perani, E., Stella, C., Rudaz, S., Lubda, D., Mellerio, G., Veuthey, J.-L., Caccialanza, G., Massolini, G.

“…The preparation and characterization of a new trypsin-based bioreactor is here described for on-line protein digestion and peptide analysis. Trypsin was…”
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Evaluation of an in-capillary approach for performing quantitative cytochrome P450 activity studies by Curcio, R, Nicoli, R, Rudaz, S, Veuthey, J.-L

“…An automated in-capillary assay requiring very small quantities of reagents was developed for performing in vitro cytochrome P450 (CYP450) drug metabolism…”
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Protein precipitation for the analysis of a drug cocktail in plasma by LC–ESI–MS by Souverain, S, Rudaz, S, Veuthey, J.-L

“…Three protein precipitation (PP) procedures with acetonitrile (ACN), perchloric acid (PA) and trichloroacetic acid (TCA) were investigated for the analysis of…”
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Impact of (CYP3A Inhibiting) Antiretroviral Treatment on the Pharmacokinetics and Pharmacodynamics of Clopidogrel and Prasugrel by Marsousi, N, Daali, Y, Fontana, P, Reny, J.L, Rudaz, S, Calmy, A, Lecompte, T. Doco, Desmeules, J.A, Samer, C.F

“…[...]they may inhibit prasugrel and clopidogrel bioactivation pathways and reduce their efficacy. Area Under Concentration-time curve* Wilcoxon signed-rank…”
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Trypsin immobilization on an ethylenediamine-based monolithic minidisk for rapid on-line peptide mass fingerprinting studies by Nicoli, R., Rudaz, S., Stella, C., Veuthey, J.-L.

“…The aim of this work was to develop a trypsin-based micro-immobilized enzyme reactor prepared on a monolithic ethylenediamine BIA Separations CIM (convective…”
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Reliable low-cost capillary electrophoresis device for drug quality control and counterfeit medicines by Marini, R.D., Rozet, E., Montes, M.L.A., Rohrbasser, C., Roht, S., Rhème, D., Bonnabry, P., Schappler, J., Veuthey, J.-L., Hubert, Ph, Rudaz, S.

“…The proportion of counterfeit medicines is dramatically increasing these last few years. According to numerous official sources, in some pharmaceutical…”
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High Power LEDs - Technology Status and Market Applications by Steranka, F.M., Bhat, J., Collins, D., Cook, L., Craford, M.G., Fletcher, R., Gardner, N., Grillot, P., Goetz, W., Keuper, M., Khare, R., Kim, A., Krames, M., Harbers, G., Ludowise, M., Martin, P.S., Misra, M., Mueller, G., Mueller-Mach, R., Rudaz, S., Shen, Y.-C., Steigerwald, D., Stockman, S., Subramanya, S., Trottier, T., Wierer, J.J.

“…High power light emitting diodes (LEDs) continue to increase in output flux with the best III‐nitride based devices today emitting over 150 lm of white, cyan,…”
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In vivo characterisation of a novel water-soluble Cyclosporine A prodrug for the treatment of dry eye disease by Rodriguez-Aller, M., Kaufmann, B., Guillarme, D., Stella, C., Furrer, P., Rudaz, S., El Zaoui, I., Valamanesh, F., Di Tommaso, C., Behar-Cohen, F., Veuthey, J.-L., Gurny, R.

“…The novel water-soluble Cyclosporine A prodrug showed interesting in vivo properties: low elimination from the precorneal area and deep ocular penetration…”
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A multi-target screening analysis in human plasma using fast liquid chromatography–hybrid tandem mass spectrometry (Part I) by Viette, V., Guillarme, D., Mylonas, R., Mauron, Y., Fathi, M., Rudaz, S., Hochstrasser, D., Veuthey, J.-L.

“…Evaluate a new LC–MS/MS screening method for drugs and drugs of abuse as an alternative to the existing methods used in clinical toxicology laboratories. The…”
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Models to estimate overall analytical measurements uncertainty: Assumptions, comparisons and applications by Rozet, E., Rudaz, S., Marini, R.D., Ziémons, E., Boulanger, B., Hubert, Ph

“…[Display omitted] ► Review of the models used to combine systematic and random influences. ► Highlight of the main pros and cons of these overall uncertainty…”
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Trypsin immobilization on three monolithic disks for on-line protein digestion by Nicoli, R., Gaud, N., Stella, C., Rudaz, S., Veuthey, J.-L.

“…The preparation and characterization of three trypsin-based monolithic immobilized enzyme reactors (IMERs) developed to perform rapid on-line protein digestion…”
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Total error and uncertainty: Friends or foes? by Rozet, E., Marini, R.D., Ziemons, E., Hubert, Ph, Dewé, W., Rudaz, S., Boulanger, B.

“…Guidelines ISO 17025 and ISO 15189 aim to improve the quality-assurance scheme of laboratories. Reliable analytical results are of central importance due to…”
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Evaluation of Quantification Methods to Compensate for Matrix Effects in the Analysis of Benzalkonium Chloride and Didecyldimethylammonium Chloride in Fruits and Vegetables by LC-ESI-MS/MS by Díez, C, Feinberg, M, Spörri, A. Staub, Cognard, E, Ortelli, D, Edder, P, Rudaz, S

“…Given the extensive presence of some toxic quaternary ammonium compound residues in foodstuffs arriving into the EU during 2012, the Food Authority Control of…”
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