Search Results - "RUBINO, Christopher M"

Pharmacokinetics-Pharmacodynamics of Antimicrobial Therapy: It's Not Just for Mice Anymore by Ambrose, Paul G., Bhavnani, Sujata M., Rubino, Christopher M., Louie, Arnold, Gumbo, Tawanda, Forrest, Alan, Drusano, George L.

“…Since the advent of the modern era of antimicrobial chemotherapy in the 1930s, animal infection models have allowed for the in vivo evaluation of antimicrobial…”
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Daptomycin Exposure and the Probability of Elevations in the Creatine Phosphokinase Level: Data from a Randomized Trial of Patients with Bacteremia and Endocarditis by Bhavnani, Sujata M., Rubino, Christopher M., Ambrose, Paul G., Drusano, George L.

“…Background. The objective of this analysis was to evaluate the relationship between daptomycin exposure and the probability of an elevation in the creatine…”
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Minimal Physiologically Based Pharmacokinetic and Drug‐Drug‐Disease Interaction Model of Rivaroxaban and Verapamil in Healthy and Renally Impaired Subjects by Ismail, Mohamed, Lee, Vincent H., Chow, Christina R., Rubino, Christopher M.

“…Current dosing recommendations for rivaroxaban advocate dosage reduction in patients with moderate to severe renal impairment and avoidance of concomitant…”
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Evaluation of Daptomycin Exposure and Efficacy and Safety Endpoints To Support Risk-versus-Benefit Considerations by Bhavnani, Sujata M, Ambrose, Paul G, Hammel, Jeffrey P, Rubino, Christopher M, Drusano, George L

“…The choice of an antimicrobial agent must balance optimization of efficacy endpoints with the minimization of safety events. The risk versus benefit of…”
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Pharmacological and Patient-Specific Response Determinants in Patients with Hospital-Acquired Pneumonia Treated with Tigecycline by BHAVNANI, Sujata M, RUBINO, Christopher M, HAMMEL, Jeffrey P, FORREST, Alan, DARTOIS, Nathalie, COOPER, C. Angel, KORTH-BRADLEY, Joan, AMBROSE, Paul G

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Pharmacokinetics-Pharmacodynamics of Tigecycline in Patients with Community-Acquired Pneumonia by Rubino, Christopher M, Bhavnani, Sujata M, Forrest, Alan, Dukart, Gary, Dartois, Nathalie, Cooper, Angel, Korth-Bradley, Joan, Ambrose, Paul G

“…Exposure-response analyses for efficacy and safety were performed for tigecycline-treated patients suffering from community-acquired pneumonia. Data were…”
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Oritavancin Population Pharmacokinetics in Healthy Subjects and Patients with Complicated Skin and Skin Structure Infections or Bacteremia by RUBINO, Christopher M, VAN WART, Scott A, BHAVNANI, Sujata M, AMBROSE, Paul G, MCCOLLAM, Jill S, FORREST, Alan

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Pharmacokinetic-Pharmacodynamic Target Attainment Analyses To Evaluate In Vitro Susceptibility Test Interpretive Criteria for Ceftaroline against Staphylococcus aureus and Streptococcus pneumoniae by VAN WART, Scott A, AMBROSE, Paul G, RUBINO, Christopher M, KHARITON, Tatiana, RICCOBENE, Todd A, FRIEDLAND, H. David, CRITCHLEY, Ian A, BHAVNANI, Sujata M

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Population Pharmacokinetics of Rezafungin in Patients with Fungal Infections by Rubino, Christopher M, Flanagan, Shawn

“…Rezafungin is a novel antifungal agent of the echinocandin class with potent activity against species of and Aspergillus, including subsets of resistant…”
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Antibacterial Drug Development: A New Approach Is Needed for the Field to Survive and Thrive by Safir, M. Courtney, Bhavnani, Sujata M., Slover, Christine M., Ambrose, Paul G., Rubino, Christopher M.

“…It is often said that the marketplace for new antibiotics is broken. This notion is supported by the observation that many recently-approved antibiotics to…”
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Tigecycline Population Pharmacokinetics in Patients with Community- or Hospital-Acquired Pneumonia by RUBINO, Christopher M, FORREST, Alan, BHAVNANI, Sujata M, DUKART, Gary, COOPER, Angel, KORTH-BRADLEY, Joan, AMBROSE, Paul G

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Frequentist and Bayesian Pharmacometric-Based Approaches To Facilitate Critically Needed New Antibiotic Development: Overcoming Lies, Damn Lies, and Statistics by Ambrose, Paul G, Hammel, Jeffrey P, Bhavnani, Sujata M, Rubino, Christopher M, Ellis-Grosse, Evelyn J, Drusano, George L

“…Antimicrobial drug development has greatly diminished due to regulatory uncertainty about the magnitude of the antibiotic treatment effect. Herein we evaluate…”
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Pharmacokinetic-Pharmacodynamic Analyses for Efficacy of Ceftaroline Fosamil in Patients with Community-Acquired Bacterial Pneumonia by BHAVNANI, Sujata M, HAMMEL, Jeffrey P, VAN WART, Scott A, RUBINO, Christopher M, REYNOLDS, Daniel K, FORREST, Alan, KHARITON, Tatiana, FRIEDLAND, H. David, RICCOBENE, Todd A, AMBROSE, Paul G

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Pharmacokinetic/Pharmacodynamic Evaluation of the Dipeptidyl Peptidase 1 Inhibitor Brensocatib for Non-cystic Fibrosis Bronchiectasis by Chalmers, James D., Usansky, Helen, Rubino, Christopher M., Teper, Ariel, Fernandez, Carlos, Zou, Jun, Mange, Kevin C.

“…Background and Objective Brensocatib is an investigational, first-in-class, selective, and reversible dipeptidyl peptidase 1 inhibitor that blocks activation…”
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Evaluation of Tigecycline Penetration into Colon Wall Tissue and Epithelial Lining Fluid Using a Population Pharmacokinetic Model and Monte Carlo Simulation by RUBINO, Christopher M, LEI MA, BHAVNANI, Sujata M, KORTH-BRADLEY, Joan, SPETH, John, ELLIS-GROSSE, Evelyn, RODVOLD, Keith R, AMBROSE, Paul G, DRUSANO, George L

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Population Pharmacokinetic Analyses for Rezafungin (CD101) Efficacy Using Phase 1 Data by Lakota, Elizabeth A, Ong, Voon, Flanagan, Shawn, Rubino, Christopher M

“…Rezafungin (CD101) is a novel echinocandin antifungal agent currently in clinical development for the treatment of candidemia and invasive candidiasis…”
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Prediction of lefamulin epithelial lining fluid penetration after intravenous and oral administration using Phase 1 data and population pharmacokinetics methods by Zhang, Li, Wicha, Wolfgang W, Bhavnani, Sujata M, Rubino, Christopher M

“…Abstract Objectives Lefamulin is a semi-synthetic intravenous and oral pleuromutilin antibiotic with activity against pathogens commonly associated with…”
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Phase 1 Study of the Safety, Tolerability, and Pharmacokinetics of Vaborbactam and Meropenem Alone and in Combination following Single and Multiple Doses in Healthy Adult Subjects by Rubino, Christopher M, Bhavnani, Sujata M, Loutit, Jeffery S, Morgan, Elizabeth E, White, Dan, Dudley, Michael N, Griffith, David C

“…Meropenem-vaborbactam is a fixed combination of the novel β-lactamase inhibitor vaborbactam and the carbapenem antibiotic meropenem, developed for the…”
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Model-Based Approach for Optimizing Ceftobiprole Dosage in Pediatric Patients by Rubino, Christopher M, Cammarata, Anthony P, Smits, Anne, Schröpf, Sebastian, Polak, Mark, Litherland, Karine, Hamed, Kamal

“…Ceftobiprole is an advanced-generation cephalosporin for intravenous administration with activity against Gram-positive and Gram-negative organisms. A…”
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Worldwide Antimicrobial Susceptibility Patterns and Pharmacodynamic Comparisons of Gatifloxacin and Levofloxacin against Streptococcus pneumoniae: Report from the Antimicrobial Resistance Rate Epidemiology Study Team by JONES, Ronald N, RUBINO, Christopher M, BHAVNANI, Sujata M, AMBROSE, Paul G

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