Search Results - "ROYDS, J. A"

p53 and disease: when the guardian angel fails by Royds, J A, Iacopetta, B

“…The p53 tumor suppressor gene (TP53) is mutated more often in human cancers than any other gene yet reported. Of importance, it is mutated frequently in the…”
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Alternative lengthening of telomeres and survival in patients with glioblastoma multiforme by Hakin-Smith, V, Jellinek, DA, Levy, D, Carroll, T, Teo, M, Timperley, WR, McKay, MJ, Reddel, RR, Royds, JA

“…Despite advances in the molecular pathogenesis of glioblastoma multiforme, no reliable prognostic markers have been identified. We analysed telomerase activity…”
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MR Imaging Characteristics Associate with Tumor-Associated Macrophages in Glioblastoma and Provide an Improved Signature for Survival Prognostication by Zhou, J, Reddy, M V, Wilson, B K J, Blair, D A, Taha, A, Frampton, C M, Eiholzer, R A, Gan, P Y C, Ziad, F, Thotathil, Z, Kirs, S, Hung, N A, Royds, J A, Slatter, T L

“…In glioblastoma, tumor-associated macrophages have tumor-promoting properties. This study determined whether routine MR imaging features could predict…”
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p53 promotes adenoviral replication and increases late viral gene expression by ROYDS, J. A, HIBMA, M, DIX, B. R, HANANEIA, L, RUSSELL, I. A, WILES, A, WYNFORD-THOMAS, D, BRAITHWAITE, A. W

“…The tumor suppressor protein, p53, plays a critical role in viro-oncology. However, the role of p53 in adenoviral replication is still poorly understood. In…”
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Macrophage infiltration is associated with VEGF and EGFR expression in breast cancer by Leek, Russell D., Hunt, Nicholas C., Landers, Robert J., Lewis, Claire E., Royds, Janice A., Harris, Adrian L.

“…Angiogenesis is esential for tumour growth and metastasis. Vascular endothelial growth factor (VEGF) is a potent endothelial cell mitogen and is an important…”
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Subcellular localisation of cyclin B, Cdc2 and p21(WAF1/CIP1) in breast cancer. association with prognosis by Winters, Z E, Hunt, N C, Bradburn, M J, Royds, J A, Turley, H, Harris, A L, Norbury, C J

“…The heterodimeric cyclin B/Cdc2 protein kinase governs entry into mitosis, and can be negatively regulated through p53-mediated transcriptional induction of…”
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bcl-2 overexpression combined with p53 protein accumulation correlates with hormone-refractory prostate cancer by APAKAMA, I, ROBINSON, M. C, WALTER, N. M, CHARLTON, R. G, ROYDS, J. A, FULLER, C. E, NEAL, D. E, HAMDY, F. C

“…Seventy-seven men with histologically proven and newly diagnosed prostate cancer we investigated for the presence of bcl-2 protein overexpression and p53…”
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Expression of Interleukin-6 and Its Effects on Growth of HP75 Human Pituitary Tumor Cells by Borg, S. A., Kerry, K. E., Baxter, L., Royds, J. A., Jones, T. H.

“…The role of IL-6 in the pathogenesis of pituitary adenomas is unclear, as tumor biology is difficult to study in primary culture. We have shown here that the…”
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Nm23 protein expression in ductal in situ and invasive human breast carcinoma by Royds, J A, Stephenson, T J, Rees, R C, Shorthouse, A J, Silcocks, P B

“…Mortality associated with human breast carcinoma is almost entirely due to subsequent metastatic disease, but the molecular basis of this metastasis is not…”
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Correlation of VEGF production with IL1α and IL6 secretion by human pituitary adenoma cells by Borg, S A, Kerry, K E, Royds, J A, Battersby, R D, Jones, T H

“…Objectives: Vascular endothelial growth factor (VEGF) is considered to be the most important angiogenic factor involved in the neovascularisation of solid…”
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Comparative genomic hybridization and pathological findings in atypical teratoid/rhabdoid tumour of the central nervous system by Wharton, S. B., Wardle, C., Ironside, J. W., Wallace, W. H., Royds, J. A., Hammond, D. W.

“…The atypical teratoid/rhabdoid tumour (AT/RT) is an uncommon tumour of the central nervous system in children, characterized by the presence of a rhabdoid cell…”
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Δ122p53, a mouse model of Δ133p53α, enhances the tumor-suppressor activities of an attenuated p53 mutant by Slatter, T L, Hung, N, Bowie, S, Campbell, H, Rubio, C, Speidel, D, Wilson, M, Baird, M, Royds, J A, Braithwaite, A W

“…Growing evidence suggests the Δ133p53 α isoform may function as an oncogene. It is overexpressed in many tumors, stimulates pathways involved in tumor…”
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Response of tumour cells to hypoxia: role of p53 and NFkB by Royds, J A, Dower, S K, Qwarnstrom, E E, Lewis, C E

“…Hypoxia is present in several areas of malignant tumours and is thought to result from an inadequate rate of tumour angiogenesis, vascular collapse, or both…”
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Delta 122p53, a mouse model of Delta 133p53 alpha , enhances the tumor-suppressor activities of an attenuated p53 mutant by Slatter, T L, Hung, N, Bowie, S, Campbell, H, Rubio, C, Speidel, D, Wilson, M, Baird, M, Royds, J A, Braithwaite, A W

“…Growing evidence suggests the Delta 133p53 alpha isoform may function as an oncogene. It is overexpressed in many tumors, stimulates pathways involved in tumor…”
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Patterns of methylation of the c-myc gene in human colorectal cancer progression by SHARRARD, R. M, ROYDS, J. A, ROGERS, S, SHORTHOUSE, A. J

“…Over-expression and abnormal intracellular location of the product of the oncogene c-myc in colonic dysplasia and neoplasia may be related to alterations in…”
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Direct sequencing of the p53 gene shows absence of mutations in endometrioid endometrial adenocarcinomas expressing p53 protein by Stewart, R L, Royds, J A, Burton, J L, Heatley, M K, Wells, M

“…Aims To investigate the mutational status of the p53 gene (Tp53) in endometrial carcinomas expressing p53 protein by direct gene sequencing. Methods and…”
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p53-mediated apoptosis prevents the accumulation of progenitor B cells and B-cell tumors by Slatter, T L, Ganesan, P, Holzhauer, C, Mehta, R, Rubio, C, Williams, G, Wilson, M, Royds, J A, Baird, M A, Braithwaite, A W

“…We propose that the apoptotic function of p53 has an important role in B-cell homeostasis, which is important for the prevention of B-cell lymphomas. We…”
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Elevated p53 expression in benign meningiomas protects against recurrence and may be indicative of senescence by Hakin-Smith, V., Battersby, R. D., Maltby, E. L., Timperley, W. R., Royds, J. A.

“…Prediction of recurrence after resection of benign meningiomas represents a significant clinical problem. A prospective study commenced in 1984 aimed to…”
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Effect of mutation and conformation on the function of p53 in colorectal cancer by Webley, Katherine M., Shorthouse, Andrew J., Royds, Janice A.

“…In vitro studies have shown that immunoprecipitation with conformation‐specific antibodies allows discrimination between different forms of p53; however, the…”
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IL-8 mRNA expression by in situ hybridisation in human pituitary adenomas by Suliman, ME, Royds, JA, Baxter, L, Timperley, WR, Cullen, DR, Jones, TH

“…Several cytokines have been shown to be expressed in normal and adenomatous pituitary tissue. Recently, interleukin-8 (IL-8) mRNA was identified by reverse…”
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